Anna Gabrielyan - Inflammation & Ubiquitin Signalling divisions

Anna Gabrielyan - Inflammation & Ubiquitin Signalling divisions

Location: 
Davis Auditorium
Start Time: 
Fri, 30/09/2022 - 3:00pm
End Time: 
Fri, 30/09/2022 - 4:00pm

WEHI PhD Completion Seminar hosted by Dr Rebecca Feltham



Anna Gabrielyan

PhD Student

Silke Laboratory, Inflammation division - Infection, Inflammation & Immunity Theme

Feltham Laboratory , Ubiquitin Signalling division - Healthy Development and Ageing Theme

WEHI


 

Identifying and characterising novel cell death regulators of TRAIL-dependent cholangitis-like liver injury

 

Davis Auditorium

Online access via Slido and enter code #WEHIphdcompletion

Including Q&A session

Followed by refreshments in Tapestry Lounge

 

Primary sclerosing cholangitis (PSC) is a progressive, idiopathic cholangiopathy characterized by chronic inflammation of the biliary epithelium. PSC promotes fibrosis of intra- and extrahepatic bile ducts and chronic cholestasis leading to premature death due to irreversible liver damage. Since PSC creates chronic inflammation in the biliary tree, patients with PSC are also at high risk to develop malignant cholangiocarcinoma. Tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated signalling plays a principal role in the pathogenesis of PSC with TRAIL-mediated apoptosis substantially contributing to the disease. However, the etiology and exact pathogenic mechanisms of TRAIL-dependent PSC, or inflammation-associated cholangiocarcinogenesis are still largely unclear. Our work has identified two novel regulators of TRAIL-induced cell death and cancer cell survival. We explore the role of these regulators in the pathogenesis of TRAIL-mediated PSC, as well as in TRAIL-induced cell death in cancer.

 

All welcome!