Tgfb signalling in Blimp1-mediated T cell differentiation
Project type
Honours
| Supervisor(s) | Division | |
| (Primary) | Molecular Immunology | .(JavaScript must be enabled to view this email address) |
| (Co-supervisor) | Molecular Immunology | .(JavaScript must be enabled to view this email address) |
Details of project
We have shown that Tgfb, a cytokine essential for the differentiation of IL-17-producing CD4 T cells (Th17) and regulatory T cells, suppresses the transcription factor Blimp1. Blimp1 is a master regulator of B and T cell differentiation.
We aim to elucidate the signaling pathway, that mediates Tgfb mediated Blimp1 repression in T cells.
Project references
Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz G, Smyth GK, Busslinger M, Nutt SL, Kallies A. The transcription factors Blimp1 and IRF4 jointly control differentiation and function of effector regulatory T cells. Nat. Immunol. 2011 12:304-11.
Research interests
Lymphocyte differentiation
Research theme
Chronic inflammatory diseases
Scientific discipline
- Biochemistry
- Cell Biology
- Immunology
Keywords
CD4 T cells, IL-17, Tgfb