Probing the control of fate and function in the blood forming system

Probing the control of fate and function in the blood forming system

Project details

Continual production of blood cells throughout life is critical to our health and this is the responsibility of the hematopoietic stem cell (HSC). A practical understanding of how different classes of blood cells, including HSCs, are produced and how their activities are regulated is highly sought-after. This knowledge is critical to efforts in regenerative medicine.

We use advanced imaging (3D and 4D quantitative imaging), gene expression analysis (population and single-cell levels), and genetic manipulation technologies (CRISPR/Cas9 genome editing) with the goal of understanding how lineage fate and function is instructed during early life.

Projects available to promising PhD candidates:

  • Understanding the molecular control of blood progenitor/stem cell formation
  • Understanding the environmental and molecular mechanisms of pre-natal platelet production
  • Exploring technological applications for developmental hematopoiesis

About our research group

Our laboratory investigates how blood cell fate and function is controlled during life, and how these processes can be manipulated to enhance medical treatments. Within the disciplines of developmental and cellular biology, we use cutting edge technologies to investigate how the complex interactions between environment, genes and signalling pathways converge to instruct the first lineage fate decisions.

The Taoudi laboratory consists of one postdoctoral researcher, a Masters student, an Honours student, and a research assistant. Students will be trained in the fundamentals of basic research and the application of new technologies, take an active part in academic discourse, and guided towards intellectual independence.

 

 

Microscopy images
Using advanced 3D imaging technologies we are for the first time able to look into the intact organism (main image) to explore the early blood forming system. Inset, and indicated by arrows, are some of the first functional blood cells produced during early life.

 

Researchers:

Dr Samir Taoudi

Dr Samir Taoudi
Dr
Samir
Taoudi
Laboratory Head

Project Type: