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  • ARC Future Fellowships 2010–14
  • Regulation of host cell invasion in Toxoplasma parasites
  • Understanding the interplay between JAK2 and SOCS3 in blood diseases
  • ARC Future Fellowships 2011–15
  • X Inactivation and Epigenetics
  • Scientists
  • Analysis of structural variation in sequencing data in pedigrees
  • Computational methods and analysis of tumour genome sequence data
  • Structure function analyses of a malaria parasite adhesin
  • Intramembrane substrate recognition by membrane tethered E3 ubiquitin ligases
  • Immune evasion strategies by malaria parasites
  • Virus miRNAs that target the host innate immune response and inflammation
  • Type 2 diabetes – new inflammation and cell death pathways
  • Functions and structures of innate immune protein complexes
  • Export of virulence proteins to the surface of the malaria-infected red blood cell of humans
  • Understanding how effector proteins are exported to the malaria-infected red blood cell
  • Identification of proteins required for sexual development of malaria parasites
  • Targeting cell death pathways in parasites
  • Role of exported malarial proteins in modifying infected liver cells
  • Molecular mechanisms of cell traversal by Plasmodium falciparum
  • Discovery and validation of novel antigens as serological markers for recent malaria exposure
  • Selective targeting of Bcl-2 proteins in cancer
  • The role and mechansim of apoptosis in haematopoiesis and cancer
  • Plasmepsin V inhibitors as antimalarial agents
  • Development of molecular markers to determine the burden of P. vivax relapses in longitudinal cohort
  • The role of chemokines in severe malaria and control of parasite biomass
  • Development of B cell memory and antibody responses to malaria
  • The role of SPSB1 in regulating the innate immune response
  • Delivery of RNAi therapeutics by the mammalian SID-1 orthologs
  • Dissecting the role of Sidt2 in cell cycle control and tumor suppression
  • Investigating interactions of Bcl-2 proteins during apoptosis by mass spectrometry
  • Imaging protein conformation and interactions during apoptosis
  • Design, synthesis and testing of selective kinase inhibitors
  • Identification of novel cancer targets
  • When splicing goes awry – a mechanism for cancer onset and progression?
  • Identification and characterisation of a novel mutation that predisposes to rheumatoid arthritis
  • Creating cancer models in zebrafish
  • The role of Bcl-G in colon cancer development
  • Design and synthesis of bromodomain inhibitors and study in models of acute myeloid leukaemia
  • The role of the epigenetic modifier Smchd1 in cancer
  • Development of new inhibitors of tyrosyl tRNA synthetase for the treatment of malaria
  • Understanding the regulation of brain and endocrine development through central control of chromatin
  • Structural and biological characterization of Bax, an important mediator of programmed cell death
  • How do mutations in kinase-like 'pseudokinase' proteins cause cancer and blood cell malignancies
  • Emerging roles for 'minor class' splicing in colorectal cancer - not so minor after all
  • Design of protease inhibitors that block erythrocyte invasion for treating malaria
  • Platelet function in cancer progression
  • Type 1 insulin-like growth factor receptor - structural studies of a prospective anti-cancer target
  • Understanding the regulation of immune cell fates
  • A novel model of gastric adenocarcinoma and assessment of new therapies
  • Development of new inhibitors of RIPK2 kinase
  • Physiological regulators of ion channels
  • Development of inhibitors of apoptosis
  • Drug discovery screening in zebrafish embryos
  • Role of the Hhex transcription factor in blood development and leukaemia
  • Structural analysis of the molecular motor driving Apicomplexan parasite motility
  • Bioinformatics tools for sequencing mixed populations
  • Investigation of AXIN1 germline mutations from patients with multiple adenomas
  • Investigating the mechanism of action of R-spondin
  • Molecular and structural analysis of malaria invasion
  • Programmed cell death and angiogenesis
  • Epigenetic regulators of embryonic lung progenitor cells
  • Post-Translational Modifications Affecting B Cell Behaviour
  • Identifying regulators of malaria parasite motility via high-content imaging
  • Cytokine signalling in myeloid leukaemia
  • Discovery of colorectal cancer subtype associated tumour suppressor genes
  • Identification of key regulators of epithelial-mesenchymal transition and metastasis
  • Improving treatment selection for colon cancer using molecular markers

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