Infection & Immunity

The Leishmania Laboratory - Recent Publications

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Research Overview | Research Divisions | Online Resources | Collaborative Research

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Cancer & Haematology | Molecular Genetics of Cancer | Immunology | Infection & Immunity
Autoimmunity & Transplantion | Genetics & Bioinformatics | Structural Biology

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Lab publications in the last 5 years

1. Roberts LJ, Baldwin TM, Curtis JM, HANDMAN E, Foote SJ. 1997. Resistance to Leishmania major is linked to both the H2 region on chromosome 17 and to chromsome 9. J Exp Med 185: 1705-1710.
2. Sjölander A, Baldwin TM, Curtis JM, HANDMAN E. 1998 Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response is required for generation of immunity to leishmaniasis. J Immunol 160: 3949-3957.
3. Sjölander A, Baldwin TM, Curtis JM, Lövgren Bengtsson K, HANDMAN E. 1998 Vaccination with recombinant parasite surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection. Vaccine 16: 2077-2084.
4. Kemp M, HANDMAN E, Kamp K, Ismail A, Mustafa MD, Kordonfani AY, Bendtzen K, Kharasmi A, Theander TG. 1998. The leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L.major. FEMS Immunol. Med Microbiol 20: 209-218.
5. Waller RF, Keeling PJ, Donald RG, Striepen B, HANDMAN E, Lang-Unnasch N, Cowman AF, Besra GS, Roos DS, McFadden GI. 1998. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci USA 95: 12352-12357.
6. Piani A, Ilg T, Elefanty EG, Curtis J, HANDMAN E. 1999. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function. Microbes Infect 1: 589-599.
7. Roberts LJ, Baldwin TM, Speed TP, HANDMAN E, Foote SJ. 1999. Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol 29: 3047-3050.
8. Stierhof Y-D, Bates, PA, Jacobson RL, Schlein Y, HANDMAN E, Ilg T. 1999. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three dimensional meshworks that obstruct the digestive tract of infected sandfly vectors. Eur J Cell Biol 78: 675-689.
9. Alexander WS, Starr R, Fenner JE, Scott CL, HANDMAN E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TWH, Nicola NA, Hertzog P, Metcalf D, Hilton DJ. 1999. SOCS1 is a crtitical inhibitor of interferon g signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98: 597-608.
10. Ilg T, Montgomery J, Stierhof D-Y, HANDMAN E. 1999. Molecular cloning and characterization of a novel repeat-containing Leishmania major gene ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor. J Biol Chem 274: 31410-31420.
11. HANDMAN E, Hadjinoormohammadi A, Curtis JM, Baldwin T, Sjölander A. 2000. Therapy of murine cutaneous leishmaniasis by DNA vaccination. Vaccine 18: 3011-3017
12. Scott CL, Roe L, Curtis JM, Baldwin T, Robb L, Begley GC, HANDMAN E. 2000. Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection. Microb. Infect. 2: 1-8
13. Montgomery J, Ilg T, Kobe B, HANDMAN E. 2000. Identification and predicted structure of a leucine rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2. Mol Biochem Parasitol. 107: 289-295
14. Roberts LJ, Foote SJ, HANDMAN E. 2000. Leishmania major: A new standard for the graphical representation of disease progression and parasite burden. Parasite Immunol. 22: 231-237
15. Jensen ATR, Curtis J, Montgomery J, HANDMAN E, Theander TG. 2001 Leishmania donovani: Molecular and Immunological characterisation of the Glucose Regulated Protein 78. Biochim. Biophys. Acta 36471:1-15.
16. Jensen ATR, Kemp K, Theander TG, HANDMAN E. 2001. Cloning, expression and antigenicity analysis of the Leishmania donovani reductase. Acta Pathologica, Microbiologica Et Immunologica Scandinavia (APMIS) 109: 461-468.
17. Noormohammadi AH, Hochrein H, Curtis JM, Baldwin TM. HANDMAN E. 2001. Paradoxical effects of IL-12 in leishmaniasis in the presence and absence of vaccinating antigen. Vaccine 19: 4043-4052.
18. Henri S, Vremec D, Kamath A, Waithman J, Williams S, Benoist C, Burnham K, Saeland S, HANDMAN E, Shortman K. 2001. The Dendritic Cell Populations of Mouse Lymph Nodes. J. Immunol. 167:741-748.
19. Bullen DVR, Darwiche R, Metcalf D, HANDMAN E, Alexander WS. 2001. Neutralisation of interferon g in neonatal SOCS1 -/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease. Immunology 104:92-98.
20. Croker BA, HANDMAN E. Hayball JD, Baldwin TM. Voigt V, Yang F-C, Williams DA, Roberts AW. 2002. Rac2 deficient mice display perturbed T cell distribution and chemotaxis, but only minor abnormalities in TH1 responses. Immunology and Cell Biology 80:231-240.
21. Montgomery J, HANDMAN E. 2002. Genetic and structural heterogeneity of proteophosphoglycans in Leishmania. Mol. Biochem. Parasitol. 121:75-85.
22. Henri S, Curtis J, Hochrein H, Vremec D, Shortman K D, and HANDMAN E.2002. Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major : inverse relationship to IL-12 production. Infect. Immun.70: 3874-3880
23. Corcoran L, Vremec D, Febbraio M, Baldwin T and HANDMAN E. 2002. Differential regulation of CD36 expression in antigen presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages. International Immunol. 14: 1099-1104.
24. Foth B, Piani A, Curtis J, Ilg T, McConville M C and HANDMAN, E.2002. Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome. Int. J. Para. (in press)

Reviews and Book Chapters

1. HANDMAN E. 1997. Leishmania vaccines: old and new. Parasitol Today 13: 236-238.
2. Foote SJ, Speed T, Handman E. 1998. What can bioinformatics do for parasitology research? Parasitol Today 14: 346-347
3. Ilg T, HANDMAN E, Ng K, Stierhof Y-D, Bacic A. 1999. Mucin-like proteophosphoglycans from the protozoan parasite Leishmania. Trends Glycosci Glycotechn 11: 1-19.
4. HANDMAN E. 1999. Cell biology of Leishmania. Adv Parasitol 44: 2-39.
5. Roberts LJ, HANDMAN E, Foote SJ. 2000. Leishmaniasis in the new genetic era. British Med. J. 321:801-804
6. HANDMAN E, Sjölander A, Ilg T, Montgomery J, Piani A, Curtis JM, Elso C, Roberts LJ, Foote SJ. 2000. Host-Parasite Interactions in leishmaniasis. The Immunologist 8:42-44
7. HANDMAN E, 2001. Leishmaniasis: Current status of Vaccine Development. Clin Microbiol Rev 14:229-243
8. HANDMAN E. 2001. Leishmania Virulence: it’s a knockout! Trends in Parasitology 17:60
9. HANDMAN E. (2001) Protective Saliva: a novel approach to a Leishmania vaccine. Trends in Parasitology 17: 513-514
10. HANDMAN, E and Bullen, D (2002) Interaction of Leishmania with the host macrophage. Trends in Parasitology 18:332-335