Type 2 diabetes

Type 2 diabetes

Inflammasome
Type 2 diabetes is characterised by high blood glucose levels. This leads to serious health complications. Type 2 diabetes is strongly associated with obesity and ageing. More than 850,000 Australians have type 2 diabetes, and its incidence in increasing. Our researchers are revealing how type 2 diabetes develops, and advancing new strategies to treat this condition.

 

 

Our type 2 diabetes research

Our type 2 diabetes research includes laboratory and clinical studies aimed at:

  • Revealing how tissues become resistant to insulin and developing new strategies to reverse this.
  • Defining the role of inflammation in type 2 diabetes, and investigating ways to reduce inflammation.
  • Understanding how obesity contributes to type 2 diabetes.
  • Leading clinical trials to discover the impact of weight loss on type 2 diabetes.

What is type 2 diabetes?

High blood glucose levels occur in diabetes because the body does not respond properly to the hormone insulin, which controls glucose levels

In type 2 diabetes, insulin is less effective in controlling blood glucose levels. This is because the key targets of insulin, liver and muscle cells, are less sensitive to its effects. This condition is termed ‘insulin resistance’.

Insulin resistance may be triggered by chronic inflammation. This is caused by immune cells within fat tissue releasing substances that inflame neighbouring tissues. The fatter a person becomes, the more inflammation their fat tissue generates.

Insulin resistance leads to high levels of glucose in the blood. This can reinforce insulin resistance, potentially by exacerbating inflammation. At the same time, high levels of glucose in the blood trigger more insulin release from the pancreas. This triggers inflammation within the pancreas, which kills the insulin-secreting beta cells. This leads to less insulin being produced, worsening the blood glucose levels and increasing inflammation.

 

 

Type 2 diabetes in Australia

Around 850,000 Australians have been diagnosed with type 2 diabetes. It is estimated that a similar number of Australians have the condition but have not been diagnosed, putting them at increased risk of complications. Complications of type 2 diabetes are a significant health burden for Australia.

Type 2 diabetes risk factors

A person’s risk of developing type 2 diabetes depends on their age and their genetic makeup, but also on ‘lifestyle’ factors.

Certain inherited, genetic factors increase a person’s chances of developing type 2 diabetes. This explains why relatives of someone with type 2 diabetes are more likely to also have this condition. It also explains why type 2 diabetes rates are higher in people from certain racial and ethnic groups. Aboriginal Australians have a high risk of developing type 2 diabetes.

A person’s chances of developing type 2 diabetes are increased if they:

  • Are older: type 2 diabetes risk increases with age
  • Are overweight or obese
  • Have high blood pressure
  • Have previously had gestational diabetes
  • Are female

Reducing body weight and increasing physical fitness can reduce a person’s chances of developing type 2 diabetes.

How is type 2 diabetes treated?

The severity of type 2 diabetes can differ between people. Some people show insulin resistance but normal levels of insulin production; in other people, the disease is predominantly associated with reduced insulin production. These factors can also change with time.

The severity and characteristics of a person’s type 2 diabetes influences how they are treated. Blood glucose levels can often be controlled by regular exercise and eating a healthy diet, which does not raise blood sugar rapidly.

Our researchers are trialing whether weight loss can be used as a treatment for type 2 diabetes.

Some people with type 2 diabetes also require medications that:

  • Reduce blood sugar levels.
  • Improve how cells respond to insulin.
  • Stimulate insulin production by the pancreas.

When insufficient insulin is produced, a person with type 2 diabetes needs to start taking additional insulin. This is given by injections or through a pump.

In the long term, people with type 2 diabetes may need additional treatments for complications of their disease. Common complications of type 2 diabetes include:

  • Kidney disease (diabetic nephropathy)
  • Eye disease and blindness (diabetic retinopathy)
  • Nerve damage (diabetic neuropathy)
  • Damage to blood vessels, which together with nerve damage can lead to serious problems in the hands and feet
  • Heart disease and stroke.

For more information, and support for people with type 2 diabetes please visit Diabetes Australia.

Researchers: 

Dr John Wentworth

Dr John Wentworth in the lab
Dr
John
Wentworth
Clinician Scientist

Dr Seth Masters

Seth Masters
Dr
Seth
Masters
Laboratory Head

Dr Colin Ward

Dr Colin Ward in his office
Dr
Colin
Ward
Laboratory Head
Super Content: 
Dr John Wentworth interviewed on 9News

Dr John Wentworth discusses clinical trial of gastric banding

Image of pancreatic tissue

How inflammatory cells in fat contribute to type 2 diabetes

Dr Mike Lawrence in his office

A landmark discovery about how insulin docks on cells could help in the development of improved types of insulin for treating both type 1 and type 2 diabetes.