PhD and Honours projects: 2013 intake | Walter and Eliza Hall Institute of Medical Research

PhD and Honours research projects: 2013 intake

Find out more about our Honours program or PhD program.

Download a booklet of all PhD and Honours research projects.

Browse the projects in the table or sort them by clicking the table headings.

As project details become available, they will be listed here. Please check back frequently.

Research Theme	Research Division	Research Project Title	Supervisor(s)
Infectious diseases	Infection and Immunity	Regulation of host cell invasion in Toxoplasma parasites	Dr Chris Tonkin Professor Alan Cowman
Cancer	Cancer and Haematology	Understanding the interplay between JAK2 and SOCS3 in blood diseases	Dr Jeff Babon Dr James Murphy
Cancer	Bioinformatics	Analysis of structural variation in sequencing data in pedigrees	Dr Melanie Bahlo Dr Tony Papenfuss Professor Terry Speed
Immunology	Structural Biology	Intramembrane substrate recognition by membrane tethered E3 ubiquitin ligases	Dr Melissa Call Dr Matthew Call
Cancer	Bioinformatics	Computational methods and analysis of tumour genome sequence data	Dr Tony Papenfuss Professor Terry Speed
Infectious diseases	Infection and Immunity	Immune evasion strategies by malaria parasites	Dr Wai-Hong Tham Professor Alan Cowman
Infectious diseases	Infection and Immunity	Structure function analyses of a malaria parasite adhesin	Dr Wai-Hong Tham Professor Alan Cowman
Chronic inflammatory diseases	Inflammation Cell Signalling and Cell Death	Type 2 diabetes – new inflammation and cell death pathways	Dr Seth Masters Dr James Vince
Infectious diseases	Inflammation	Virus miRNAs that target the host innate immune response and inflammation	Dr Seth Masters Dr Motti Gerlic
Chronic inflammatory diseases	Inflammation	Functions and structures of innate immune protein complexes	Dr Seth Masters Dr Sandra Nicholson
Infectious diseases	Infection and Immunity	Export of virulence proteins to the surface of the malaria-infected red blood cell of humans	Professor Alan Cowman Dr Justin Boddey
Infectious diseases	Infection and Immunity	Understanding how effector proteins are exported to the malaria-infected red blood cell	Professor Alan Cowman Dr Justin Boddey
Infectious diseases	Infection and Immunity	Identification of proteins required for sexual development of malaria parasites	Professor Alan Cowman Dr Neta Regev-Rudzki
Infectious diseases	Structural Biology Chemical Biology	Targeting cell death pathways in parasites	Dr Doug Fairlie Dr Erinna Lee Dr Guillaume Lessene
Infectious diseases	Infection and Immunity	Role of exported malarial proteins in modifying infected liver cells	Dr Justin Boddey Professor Alan Cowman
Infectious diseases	Infection and Immunity	Molecular mechanisms of cell traversal by Plasmodium falciparum	Dr Justin Boddey Professor Alan Cowman
Cancer	Structural Biology Molecular Genetics of Cancer	Selective targeting of Bcl-2 proteins in cancer	Dr Doug Fairlie Dr Erinna Lee Dr Marco Herold
Cancer	Structural Biology Bioinformatics	The role and mechansim of apoptosis in haematopoiesis and cancer	Dr Doug Fairlie Dr Erinna Lee Dr Benjamin Kile
Infectious diseases	Chemical Biology Infection and Immunity	Plasmepsin V inhibitors as antimalarial agents	Dr Brad Sleebs Dr Justin Boddey
Cancer	Structural Biology	Investigating the mechanism of action of R-spondin	Dr Chin Wee Tan Professor Antony Burgess
Infectious diseases	Infection and Immunity	Discovery and validation of novel antigens as serological markers for recent malaria exposure	Professor Ivo Mueller Professor Louis Schofield
Infectious diseases	Infection and Immunity Bioinformatics	Development of molecular markers to determine the burden of P. vivax relapses in longitudinal cohort	Professor Ivo Mueller Dr Tony Papenfuss Dr Aaron Jex, Department of Veterinary Medicine, The University of Melbourne
Infectious diseases	Infection and Immunity	The role of chemokines in severe malaria and control of parasite biomass	Dr Diana Hansen Professor Louis Schofield
Infectious diseases	Infection and Immunity	Development of B cell memory and antibody responses to malaria	Dr Diana Hansen Professor Louis Schofield
Chronic inflammatory diseases	Inflammation	Delivery of RNAi therapeutics by the mammalian SID-1 orthologs	Dr Ken Pang Professor Ian Wicks
Cancer	Inflammation Molecular Genetics of Cancer	Dissecting the role of Sidt2 in cell cycle control and tumor suppression	Dr Ken Pang Professor Andreas Strasser
Chronic inflammatory diseases	Molecular Genetics of Cancer	Identification and characterisation of a novel mutation that predisposes to rheumatoid arthritis	Dr Philippe Bouillet Professor Andreas Strasser
Cancer	Molecular Genetics of Cancer Cell Signalling and Cell Death	The role of Bcl-G in colon cancer development	Dr Philippe Bouillet Dr Tracy Putoczki Professor Andreas Strasser
Cancer	Molecular Medicine Cancer and Haematology	The role of the epigenetic modifier Smchd1 in cancer	Dr Marnie Blewitt Dr James Murphy
Infectious diseases	Chemical Biology Infection and Immunity	Development of new inhibitors of tyrosyl tRNA synthetase for the treatment of malaria	Dr Brad Sleebs Associate Professor Alex Maier (ANU) Dr Guillaume Lessene
Developmental biology	Development and Cancer	Understanding the regulation of brain and endocrine development through central control of chromatin	Dr Anne Voss Dr Tim Thomas
Cancer	Structural Biology	Structural and biological characterization of Bax, an important mediator of programmed cell death	Dr Peter Czabotar Professor Peter Colman
Infectious diseases	Inflammation	The role of SPSB1 in regulating the innate immune response	Dr Sandra Nicholson Dr Lukasz Kedzierski
Cancer	Cancer and Haematology Structural Biology	How do mutations in kinase-like ‘pseudokinase’ proteins cause cancer and blood cell malignancies	Dr James Murphy Dr Jeff Babon
Cancer	Cell Signalling and Cell Death Personalised Medicine and Systems Biology	Investigating interactions of Bcl-2 proteins during apoptosis by mass spectrometry	Dr Grant Dewson Dr Andrew Webb
Cancer	Cell Signalling and Cell Death	Imaging protein conformation and interactions during apoptosis	Dr Grant Dewson Dr Danny Hatters
Cancer	Chemical Biology	Design, synthesis and testing of selective kinase inhibitors	Dr Christopher Burns Dr Guillaume Lessene
Cancer	Chemical Biology	Identification of novel cancer targets	Professor David Huang Dr Mark van Delft
Cancer	Chemical Biology	When splicing goes awry – a mechanism for cancer onset and progression?	Dr Minni Anko Associate Professor Joan Heath
Cancer	Chemical Biology	Design and synthesis of bromodomain inhibitors and study in models of acute myeloid leukaemia	Dr Christopher Burns Professor David Huang
Cancer	Chemical Biology	Emerging roles for ‘minor class’ splicing in colorectal cancer - not so minor after all	Dr Ben Williams Associate Professor Joan Heath Dr Karen Doggett
Cancer	Structural Biology	Type 1 insulin-like growth factor receptor - structural studies of a prospective anti-cancer target	Associate Professor Mike Lawrence Dr Jacqui Gulbis
Immunology	Chemical Biology Cell Signalling and Cell Death	Development of new inhibitors of RIPK2 kinase	Dr Guillaume Lessene Dr Ueli Nachbur Associate Professor John Silke
Cancer	Chemical Biology	Creating cancer models in zebrafish	Dr Karen Doggett Associate Professor Joan Heath
Immunology	Structural Biology	Physiological regulators of ion channels	Dr Jacqui Gulbis Dr David Miller Associate Professor Mike Lawrence
Cancer	Chemical Biology	Development of inhibitors of apoptosis	Dr Guillaume Lessene Dr Mark van Delft Professor David Huang
Cancer	Molecular Genetics of Cancer	A novel model of gastric adenocarcinoma and assessment of new therapies	Dr Lorraine A O'Reilly Professor Andreas Strasser
Cancer	Chemical Biology	Drug discovery screening in zebrafish embryos	Dr Karen Doggett Associate Professor Joan Heath
Cancer	Cancer and Haematology	Role of the Hhex transcription factor in blood development and leukaemia	Dr Matthew McCormack Dr Benjamin Shields Professor Warren Alexander
Infectious diseases	Infection and Immunity Structural Biology	Structural analysis of the molecular motor driving Apicomplexan parasite motility	Dr Chris Tonkin Associate Professor Mike Lawrence
Cancer	Bioinformatics	Bioinformatics tools for sequencing mixed populations	Dr Tony Papenfuss Professor Ivo Mueller Professor Terry Speed
Cancer	Structural Biology	Investigation of AXIN1 germline mutations from patients with multiple adenomas	Dr Maree Faux Dr Nadia Kershaw Professor Antony Burgess
Infectious diseases	Chemical Biology Infection and Immunity	Design of protease inhibitors that block erythrocyte invasion for treating malaria	Dr Brad Sleebs Professor Alan Cowman Mr Tony Triglia
Cancer	Cancer and Haematology	Platelet function in cancer progression	Dr Emma Josefsson Professor Warren Alexander
Cancer	Immunology	Understanding the regulation of immune cell fates	Professor Phil Hodgkin Dr Susanne Heinzel
Cancer	Development and Cancer Cell Signalling and Cell Death	Programmed cell death and angiogenesis	Dr Leigh Coultas Dr Grant Dewson
Infectious diseases	Infection and Immunity	Molecular and structural analysis of malaria invasion	Professor Alan Cowman Dr Tony Hodder
Cancer	Stem Cells and Cancer Molecular Medicine	Epigenetic regulators of embryonic lung progenitor cells	Dr Marie-Liesse Asselin-Labat Dr Marnie Blewitt
Immunology	Immunology	Post-Translational Modifications Affecting B Cell Behaviour	Associate Professor David Tarlinton Dr Simona Infantino
Infectious diseases	Infection and Immunity Chemical Biology	Identifying regulators of malaria parasite motility via high-content imaging	Dr Jake Baum Dr Kurt Lackovic
Cancer	Cell Signalling and Cell Death	Cytokine signalling in myeloid leukaemia	Dr Anissa Jabbour Assistant Professor Paul Ekert
Cancer	Personalised Medicine and Systems Biology	Discovery of colorectal cancer subtype associated tumour suppressor genes	Dr Oliver Sieber Dr Lara Lipton
Cancer	Personalised Medicine and Systems Biology	Identification of key regulators of epithelial-mesenchymal transition and metastasis	Dr Oliver Sieber Dr Lara Lipton
Cancer	Personalised Medicine and Systems Biology	Improving treatment selection for colon cancer using molecular markers	Dr Oliver Sieber Assistant Professor Peter Gibbs

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PhD and Honours research projects: 2013 intake

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