Ruth Kluck-Publications

Ruth Kluck-Publications

Researcher: 

Selected publications

  1. Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM. Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies. Nat Commun. 2016. 7, 117342 PMID: 27217060
  2. Alsop AE, Fennell SC, Bartolo RC, Tan IK, Dewson G, Kluck RM. Dissociation of Bak alpha1 helix from the core and latch domains is required for apoptosis. Nat Commun. 2015. 6, 6841 PMID: 25880232
  3. Iyer S, Bell F, Westphal D, Anwari K, Gulbis J, Smith BJ, Dewson G, Kluck RM. Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains. Cell Death Differ. 2015. Mar 6. PMID: 25744027
  4. Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM. Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane. PNAS. Vol 111, issue 39, E4076-85. PMID: 25228770
  5. Brouwer JM, Westphal D, Dewson G, Robin AY, Uren RT, Bartolo R, Thompson GV, Colman PM, Kluck RM, Czabotar PE. Bak core and latch domains separate during activation and freed core domains form symmetric homo-dimers. Molecular Cell. 55, 938-46. 10.1016/j.molcel.2014.07.016 PMID: 25175025
  6. Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Cell. 2013 Jan 31; 152(3):519-531. PMID: 23374347
  7. Westphal D, Dewson G, Czabotar PE, Kluck RM.  Molecular biology of Bax and Bak activation and action.  Biochim Biophys Acta. 2011 Apr; 1813(4):521-531. PMID: 21195116
  8. Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM.  Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.  Mol Cell. 2009 Nov 25;36(4):696-703. PMID 19941828
  9. Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM.  To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.  Mol Cell. 2008 May 9;30(3):369-80 PMID: 18471982
  10. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD.  The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.  Science. 1997 Feb 21;275(5303):1132-6 PMID: 90273151

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