Lessene-Publications

Lessene-Publications

Publications

  1. Koehler M, Bergeron P, Choo EF, Lau K, Ndubaku CO, Dudley D, Gibbons P, Sleebs BE, Rye CS, Nikolakopoulos G, Bui C, Kulasegaram S, Kersten WJA, Smith BJ, Czabotar PE, Colman PM, Huang DCS, Baell JB, Watson KG, Hasvold L, Tao Z-F, Wang L, Souers AJ, Elmore SW, Flygare JA, Fairbrother WJ, Lessene G. Structure-guided rescaffolding of selective antagonists of BCL-XL. ACS Medicinal Chemistry Letters. 2014. PMID: 24944740
  2. Roy MJ, Vom A, Czabotar PE, Lessene G. Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway. Br J Pharmacol. 2014 Sep 30;171:1973-87. PMID: 24117105.
  3. Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J. 2014 Feb 1;457(3):369-77. PMID: 24219132.
  4. Lackovic K, Lessene G, Falk H, Leuchowius KJ, Baell J, Street I. A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research - Eighteen Million Assays and Counting. Comb Chem High Throughput Screen. 2014 Jan 9. PMID: 24409955.
  5. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63. PMID: 24355989.
  6. Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hatzis E, Huang DC, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB, Lessene G. De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization. J Med Chem. 2014 Feb 27;57(4):1323-43. PMID: 24456288.
  7. Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, Wei A, Huang DC, Colman PM, Street IP, Baell JB, Watson K, Lessene G. Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-XL. Journal of Medicinal Chemistry. 2013 Jun 26;56(13):5514-40. PMID: 23767404.
  8. Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJA, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DCS, Watson KG. Structure-guided design of a selective BCL-XL inhibitor. Nature Chemical Biology. 2013;9(6):390-7.
  9. Brady RM, Hatzis E, Connor T, Street IP, Baell JB, Lessene G. Synthesis of conformationally constrained benzoylureas as BH3-mimetics. Org Biomol Chem. 2012 Jul 21;10(27):5230-7. PMID: 22648632.
  10. Brady RM, Khakham Y, Lessene G, Baell JB. Benzoylureas as removable cis amide inducers: synthesis of cyclic amides via ring closing metathesis (RCM). Org Biomol Chem. 2011 Feb 7;9(3):656-8. PMID: 21088766.