Professor David Tarlinton

Professor David Tarlinton

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Professor David Tarlinton in the lab

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Professor
David
Tarlinton

BSc(Hons) Sydney PhD Stanford

Laboratory Head

Division:

My laboratory’s research focuses on immune memory cells. These long-lived cells are crucial for the development of long-term, protective immunity to specific infections. Immune memory cells are also crucial for the success of vaccines. However, errors in the generation of immune memory can lead to diseases including autoimmune diseases, cancer and immune deficiencies.

We are particularly interested in:

  • How immune memory cells stay alive for decades.
  • What goes wrong in an immune response to promote autoimmune diseases such as lupus.
  • What goes wrong in immune responses to allow the development of cancerous cells in a condition called multiple myeloma. 

Research interest

Our research focuses on key proteins regulating lymphocyte differentiation and survival in response to antigen, focusing on cell signalling proteins, transcription factors, and cell survival regulators.

Major themes of research in my laboratory include:

  • Plasma cell differentiation
  • The formation and maintenance of immunological memory
  • The role of Lyn tyrosine kinase in regulating B cell differentiation
  • Contribution of antibody to autoimmune disease, particularly systemic lupus erythematosus. 

 

Eureka prize winning researchers, standing

Meet our Eureka Prize winning B cell researchers

Immunology researchers in the lab

Our research into how antibody producing cells become long-lived may provide insights into how certain diseases arise.

Antibodies erupting from the surface of an immune cell

Professor David Tarlinton has received an award from the Lupus Research Institute to investigate the causes of lupus and develop new approaches to its treatment