Andreas Strasser - Research projects

Andreas Strasser - Research projects

Projects

Understanding the molecular mechanisms that control cell death in health and disease

We are using genetic (Crispr/Cas9 and shRNA library) screens to identify critical regulators of cell death signalling and tumour suppression by p53. The functions of ‘hits’ from these screens will be identified by generating in vivo laboratory models that lack or over-express these proteins.

We expand substantial effort on clinical translation of our discoveries by collaborating with chemists and structural biologists at the institute, and leading biotech/pharma companies from overseas. Most notably this has assisted in development of inhibitors of pro-survival BCL-2 family members (so-called BH3 mimetics) for cancer therapy.