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Zavala1984 Zavala19869 Zavala19869 Zavala1986z Zavala19878 Zavala1987 Zavala19877C Zavala19888 Zavala1990 Zavala1990 Zavala1990 Zavala1991d Zavala1991d Zavala1991 Zavala1991 Zavala19922 Zavala1992 Zavala19929A Zavala1993V Zavala19959 Zavala19966 Zavala19979 Zavala1997W Zavala19988 Zavala19989 Zavala1998] Zeltser1989c Zeng19988SZevering19908Zevering1990@Zevering1993Zevering1994` Zhu1990 Ziggiotti1989 Zollinger1990j Zotter19929929 Webster1992 Webster1992 Webster1995 Weerasinghe1992 Weidanz19894 Weiss1987R Weiss1989 Weiss1990 Weiss1992 Weiss1997) Weiss1997* Weiss1997 Wellde19969h Wellde19981 Wellems1987N Wellems1988x Wells1996/ Welsh1987o Welsh1987 Were19911 Were19922 Were19969 Wery1995e Wry1996l White1990B White1993 Whittle1995 Wiady1997 Widmann1992 Wiesmller19915Williams19849Williams19859 Willis19919( Wilson19900 Wilson19979 Wirima19949 Wirtz1984 Wirtz1985 Wirtz1985\ Wirtz1986 Wirtz1987 Wirtz1987 Wirtz1987 Wirtz1988 Wirtz1989 Wirtz1989 Wirtz1990 Wirtz1990 Wirtz1991 Wirtz1991 Wirtz1991H Wirtz1992 Wirtz1992 Wirtz19926 Wirtz19928 Wirtz19929 Wirtz1992 Wirtz1994 Wirtz1994 Wirtz1996 Wirtz1996h Wirtz1998 Wisher19901\ Wistar19866 Wistar19911 Wittes19961 Wizel1996h Wizel1998 Wohlhueter1997y Wohlhueter19979Wongsrichanalai1991Woollett19939< Wright1990t Wright19921 Wright1995 Xiong1998L Yamada19966L Yanagi19969 Yang1997r_ Yap1990o Yoshida1980 Yoshida1987 Yoshida1990 Yoshida1991 Yoshida1991 Young1985^ Young1987 Young1987 Young1987 Young1987 Young1988 Young1988 Young1989 Young1991 Yuan19919 Yuan199196 Yuan19922 Yuan199590Yurovsky19911 Zanetti1991 Zanetti1998 Zanobi1991i Zavala19829 Zavala1983? Zavala1984 Zavala19869 Zavala19869z Zavala19878 Zavala1987 Zavala19877C Zavala19888 Zavala1990 Zavala1990 Zavala1990 Zavala1991d Zavala1991d Zavala1991 Zavala19922 Zavala1992A Zavala1993V Zavala19959 Zavala19966 Zavala19979W Zavala19988] Zeltser1989b Zeng19988c Zeng19988SZevering19908Zevering1993` Zhu1990 Ziggiotti1989 Zollinger1990j Zotter19929tter19929# 0 !#%()+-.136748<90.ml 0.no n0/N^NuNVN-@ @ P-hHJfN-@ n P!@H/./.NN^NuNVN-@ @ P-hH @ PBHJg /.NXN^NuNVN-@ @ P-hH .N^Nu Q,H@NuNVBB/-_/.N. nJNz=@gHxN(B=@>N/-@>N+l mڶ P1n n PBh n PBPN9 BWN+DN6B/. 00 !!#####%%%%(((((((())++++----.....1333666666666744444488888<9999 00000 hVTb[Strchler, D. Berger, R. Etlinger, H. Fernex, M. Matile, H. Pink, R. Schlumbom, V. Just, M. 1989vpEffects of interferons on immune response to a synthetic peptide malaria sporozoite vaccine in non-immune adultsVaccine.7457-461VaccinepiStrchler, D. Just, M. Berger, R. Reber-Liske, R. Matile, H. Etlinger, H. Takacs, B. Rudin, C. 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Glenn1998 Glenn1998M Godson19838 Godson1983 Godson1983 Godson19848 Godson19858 Godson19869 Godson1987 Godson19879s Goldman1991p Goldman1991q Goldman1992  Goldman1993 Golenda1992 Golenda1998Gonzalez19947CGonzalez1996Gonzalez-Ceron1998Gonzalez-Ceron2000 Gonzlez19947!Gonzlez19977DGonzlez1997  Good19869N Good1987i0 Good19888O Good1988P Good19888Q Good19888 Good1988 Good1988N Good1988z2 Good19898R Good1989} Good1989s Good19898S Good19908 Good19909 Good19901 Good19909 Good19911; Good19929 Good19929 Good19921 Good19928 Good19931 Good1993 Good19949 Good1994 Good1994u Good1995gI Good19954 Good19971 Gordon19858 Gordon19879 Gordon19919T Gordon19919 Gordon19911I Gordon19921 Gordon19922% Gordon199226 Gordon19922 Gordon1993 Gordon1993( Gordon19944 Gordon1995= Gordon1995 Gordon1995a Gordon19961 Gordon19977 Gordon19989 Gore19851< Gorga1991 Goswami1996 Gotch1995U Goundis1988 Gowda1999U Grady1995 Gramzinski1996 Gramzinski1997 Gramzinski19973* Gramzinski19974 Gramzinski1999 Grandi199895 Gras-Masse1990 Grau1993 Graves19891 Graves19951 Greenwood1990 Greenwood1991 Greenwood1995 Greenwood1998 Greenwood1999Grelloni19909 Greve1999 Grey1997 Grifantini1998V Grillot1990 Grillot1990{ Grillot1991 Grillot1993| Grillot1993 Gross1985 Gross1987 Gross1988] Gross1989 Gross1990 Gross1991 Gross1991I Gross1992 Gross1992F Gross1993( Gross1994 Gross1996Guidotti19988 Guillet1998 Guito1996h Guito1998 Gunawan1997 Gupta1998W Guttinger1988 Guttinger1988 Guttinger1988 Guttinger1990^ Gwadz1979 Gwadz1982 Gwadz1983> Gwadz1984 Gwadz1984# Gwadz1985 Gwadz1985$ Gwadz1986A Gwadz1986 Gwadz1987 Gwadz1987% Gwadz1988l Gysin1993 Habluetzel19903 Habluetzel19923 Haddad1999 Haeseleer1993, Hall1984 Hall19878 Hall1989kh Hall19989 Hall19989XHamilton19888YHamilton19888Hamilton19880Hamilton19922 Hammer1997 Hancock1996 Hanke1998 Hanke1998 Hanke1999 Hannan19989 Hannan19989 Hannan19999 Hannan20000 Hansson1999 Haq1998 Harinasuta19822r Harjosuwarno1993 Harris19979THarrison19918 Hart19999 Hasnain1999 Haumont1993 Hauser1995 Hawley19977 Hayashi1986 Haynes19933ZHedstrom19908Hedstrom19927'Hedstrom19949Hedstrom1994@Hedstrom1996 Hedstrom1996Hedstrom19979Hedstrom19978)Hedstrom19974*Hedstrom19977Hedstrom1998Hedstrom19989Hedstrom1998Hedstrom1998Hedstrom1999Hedstrom19999 Heimer19871" Heimer19878 Heimer1988> Heimer19933b Heinderyckx1991 Hem1991 Heppner1994 Heppner1995 Herbich1999 Hernandez2000 Herrera1987[ Herrera1992[ Herrera1992  Herrera1994 Herrera1994C Herrera1996! Herrera1997D Herrera1997 Herrera1998" Herrington1987+ Herrington19899_ Herrington19900# Herrington19917$ Herrington1991Y Herrington19918 Herrington1992z% Herrington19921_ Herrington1992 Herrington1993 Hightower1991# Hii1985 Hill19959 Hill19969 Hill19979 Hill19989h Hill19989 Hill19989 Hill19989 Hill19988 Hill19999 Hill19999 Hill19999 Hill1999 Hill20000H Hinostroza19928 Hioe19966 Hobart19949 Hobart19969 Hobart19966 Hobart19979 Hobart19977 Hobart19979) Hobart19977* Hobart19971 Hobart19989 Hobart19988 Hobart19981 Hobart19999 Hobart19999 Hockmeyer1984 Hockmeyer1985 Hockmeyer1985 Hockmeyer1985 Hockmeyer1986 Hockmeyer1987 Hockmeyer1987 Hockmeyer1987 Hockmeyer1988\ Hoffman1986 Hoffman1987 Hoffman1987] Hoffman1989Z Hoffman1990 Hoffman1990 Hoffman1990| Hoffman1991 Hoffman1991 Hoffman1991 Hoffman1991& Hoffman1991; Hoffman1991% Hoffman19926 Hoffman1992j Hoffman1992 Hoffman1992 Hoffman1992 Hoffman1992 Hoffman1992 Hoffman1993 Hoffman1993F Hoffman1993 Hoffman1994' Hoffman1994( Hoffman1994 Hoffman1994G Hoffman1995 Hoffman1995 Hoffman1995 Hoffman1995 Hoffman1995 Hoffman1996 Hoffman1996 Hoffman1996 Hoffman1996 Hoffman1996 Hoffman1996 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997) Hoffman1997* Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997? Hoffman1998h Hoffman1998 Hoffman1998 Hoffman1998 Hoffman1998 Hoffman1998 Hoffman1998 Hoffman1999 Hoffman1999 Hoffman1999 Hoffman1999 Hoffman1999 Hoffman1999 Hogh19949 Holland1998 Holland1999 Hollindale1992 Hollingdale1985rt19979 Hockmeyer1984 Hockmeyer1985 Hockmeyer1985 Hockmeyer1985 Hockmeyer1986 Hockmeyer1987 Hockmeyer1987 Hockmeyer1987 Hockmeyer1988\ Hoffman1986 Hoffman1987 Hoffman1987] Hoffman1989Z Hoffman1990 Hoffman1990 Hoffman1990| Hoffman1991 Hoffman1991 Hoffman1991 Hoffman1991& Hoffman1991% Hoffman1992 Hoffman1993 Hoffman1993 Hoffman1994' Hoffman1994 Hoffman1996 Hoffman1996 Hoffman1996 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997 Hoffman1997 Hogh19949 Hollingdale1985e1985b xIb^S J;J:X9X8:Rig, R.S. Godson, G.N.ΊD`PGodson, G.N.ΊΊpD@Pnteers immunΊΊpD Deloron, P. Campbell, G.H. Brandling-Bennett, D. Roberts, J.M. Schwartz, I.K. Odera, J.S. Lal, A.A. Osanga, C.O. de la Cruz, V. 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Lal, A.A. 1997Rapid onset of malaria-induced mortality by immunizations with lipo-peptides: an experimental model to study deleterious immune responses and immunopathology in malariaVaccine^151 65-70gVaccineZTRenggli, J. Valmori, D. Romero, J.F. Eberl, G. Romero, P. Betschart, B. Corradin, G. 1995@CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS protein-derived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria    = O Immunol. Lett.46 1-2j199-205VImmunology LettershaRnia, L. Marussig, M.S. Grillot, D. Pied, S. Corradin, G. Miltgen, F. Del Giudice, G. Mazier, D. 1991eIn vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide;   Proc Natl Acad Sci USA8818 7963-7967VOProceedings of the National Academy of Sciences of the United States of AmericaQG Lucas1991H Lucas1992 Lucas1992 Luckner1999Luescher1991@2Luescher19924Luescher19921Luescher19944N Lunde1987 Luoni1999 Luoni1999 Lussow1990E Lussow19917 Lussow1991 Lussow19922l Lussow19933 Luty1999 Lyon19877 Lyon19878= Lyon19959 Lyon19979 Lyon19989 Macdonald1999 Maewal19979h Magill19981 Maguire1989{ Maheswary1992Majarian19880]Majarian19898Majarian19900 Majori1994 Majori1996o| Malik1991 Malik1992F Malik1993 Malik1994G Malik1995* Malik1997 Maloy1984 Maloy1985 Maloy1986 Maloy1987N Maloy1987o Maloy1987 Maloy19870 Maloy1988Q Maloy1988 Maloy1988, Maloy19892 Maloy1989H Mann1994I Mann19954 Manneberg1991J Manzar1990& Maracic1990 Maracic1990 Maracic1991j Maracic1992 Maracic1993NMargalit19879Margalit19989 Margalith1996 Margalith1997 Margalith1997* Margalith1997 Margalith1998 Marinuzzi1997 Maris1996 Maris1997w Marsh1989K Martin1990 Martin19901 Martin1999{Marussig19915|Marussig1993KMarussig1997x6 Marwoto1992 Maryanski1991 Maryanski19912 Maryanski1992 Maryanski1992 Maryanski1992 Maryanski1994 Masbar19977 Mason1992b Massaer1991? Masuda19849 Masuda1986 Mateo1999 Matile19889 Matile19889 Matile19889 Matile19898 Matile19909 Matile19909 Matile19919 Matile19919 Matile1992l Matile19933w Matile1995 Matile19959 Matile1998Matousek19999L Matsumoto1996 Maxwell19985 Mazier1988V Mazier19900_ Mazier19901 Mazier1990 Mazier19911 Mazier19919M Mazier1991{ Mazier1991| Mazier19933K Mazier19979 McAdam19999 McCutchan1984- McCutchan1986. McCutchan1987/ McCutchan1987o McCutchan19871 McCutchan1988r McCutchan1988N McCutchan19882 McCutchan1989} McCutchan1989 McCutchan1989~ McCutchan1992O McCutchan1996 McGee1996McGovern19959 McMichael1998 McMichael1999 Meis19881 Meis19891` Meis19909 Meis19929 Meisner1995 Mellouk1991j Mellouk1992 Mellouk1992 Meloen19909 Melton19848 Men1994P Men1996 Men1996 Men1999 Mendis19921 Mendis1992O Menon1988s Menon19893 Merino1986P Merkle19966 Merkle19969 Merkle19999/Meshcheryakova1991*1Meshcheryakova1994 Metzger1998 Meuwissen1991 Meuwissen1991Q Mnard19979V Michel19900 Migliorini19902n Migliorini1991rR Migliorini1993rS Migot1993 Migot-Nabias1999 Miki1990b Milican1991 Milich19949 Miller19848 Miller19858 Miller19869N Miller198780 Miller19881O Miller19889P Miller19889Q Miller19889n Miller19880 Miller1988d2 Miller19891R Miller19899} Miller19899s Miller19899 Miller19909 Miller19922O Miller19966 Millet19898 Millet19919 Millet19911T Millet19923 Millet19933S Millet19939 Millet19949U Millet19952Milligan19999{ Miltgen1991| Miltgen1993K Miltgen1997Mitchell1985 VMiyahira19959WMiyahira1998 Modesti1993C Modiano1988 Modiano1992X Modiano1996 Modiano1999 Modiano1999 Momin1998 Momin1999 Mons19919 Mons19922Montenegro-James19955Montenegro-James1998 Mor1999Y Moreno19916_ Moreno19921Z Moreno19931 Moris1999U Morris19959 Morris19979 Morris19989 Morris-Jones1995 Moss19866N Moss19877 Moss19888 Moss19919 Moss19919[ Mota19969K Motard19979 Moya-Castro1997 Munesinghe1991 Munesinghe19911_ Munesinghe1992V Murata19959W Murata19989 Murata1998a" Murphy19878+ Murphy1989l Murphy19921r Murphy19933V Mller19900\ Mvondo1992 Nagata1999t Nagendran1994c Nageswara1991 Nahlen19977 Naitza1998 Naitza1999  Nakabayashi1990 Nakaie19911i Nakaie1992r] Nanzer19979^ Nardin1979e Nardin1982 Nardin19838 Nardin19879 Nardin1987" Nardin19879 Nardin1988' Nardin19899( Nardin19909 Nardin19909 Nardin19919 Nardin1991 Nardin1991 Nardin19918# Nardin19911$ Nardin19911Y Nardin19911 Nardin1992_ Nardin1992 Nardin19933Z Nardin19931` Nardin1993( Nardin19944a Nardin1995( Nardin1997c Nardin1998 Nataro19949 Nebie1999X Nebi1996j Neifer19929 Nelson19977 Nettel19989 Nettel20000 Neumann1999 Neva1987lw Newbold1989f Ng19929 Ng1998tXNicholas19888Nicholas19880 Nishikawa1988  Nishikawa1990 Nixon1996 Nkrumah1995e Norazmi1997 Noriega1994 Norman19979 Norman19979) Norman19977* Norman19971 Norman19989 Norman19999 Norman199993 Nothdurft19954 Nothdurft1996 Nothdurft1998^ Nussenzweig1979o Nussenzweig1980o Nussenzweig1980 Nussenzweig1980 Nussenzweig1980 Nussenzweig1982 Nussenzweig1982 Nussenzweig1982 Nussenzweig1982M Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983! Nussenzweig1984" Nussenzweig1984> Nussenzweig1984? Nussenzweig1984 Nussenzweig1984 Nussenzweig1984  Nussenzweig1985  Nussenzweig1985# Nussenzweig1985# Nussenzweig1985 Nussenzweig1985 Nussenzweig198511 Nardin1982 Nardin19838 Nardin19879 Nardin1987" Nardin19879 Nardin1988' Nardin19899( Nardin19909 Nardin19909 Nardin19919 Nardin1991 Nardin1991 Nardin19918# Nardin19911$ Nardin19911 Nardin1992 Nardin19933 Nardin19944 Nardin1997 Nataro19949j Neifer19929 Neva1987lw Newbold1989f Ng19929XNicholas19888Nicholas19880 Nishikawa1988  Nishikawa1990 Nkrumah1995 Noriega1994 Norman19979 Norman19979) Norman19977* Norman199713 Nothdurft19954 Nothdurft1996 Nussenzweig1982 Nussenzweig1982 Nussenzweig1982 Nussenzweig1982M Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983 Nussenzweig1983! Nussenzweig1984" Nussenzweig1984> Nussenzweig1984? 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Church1998h Church19981 Clark1997 Clarke19901 Clavijo1988 Clavijo1990 Clavijo1990 Clavijo1991 Clavijo1991 Clavijo1991Y Clavijo1991j Clavijo1992 Clavijo1992 Clavijo1992_ Clavijo1992 Clavijo1993Z Clavijo1993 Clavijo1994 Clavijo1996 Clavijo1997 Clavijo1997 Clavijo1997c Clavijo1998  Clough19859" Clyde1987+ Clyde1989$ Clyde1991 Clyde1992 Clyde1993( Clyde1994Cobelens1998: Cochran1988 Cochran1990 Cochran1992% Cochran1992 Cochran1992Cochrane19839Cochrane19839!Cochrane19849"Cochrane19849>Cochrane19849Cochrane19849#Cochrane1985 $Cochrane19869JCochrane19872%Cochrane19889kCochrane19889&Cochrane199099Cochrane19909Cochrane1990"Cochrane19919jCochrane19929Cochrane19929Cochrane19939[Cochrane19969 Cohen1993 Cohen1995 Cohen1997 Cohen1998 Cohen1999 Cohen1999 Cole19919 Collins1982 Collins1982! 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Charoenvit1998 Chatterjee19952 Chatterjee1996(H Chauca19921: Chauhan1990 Chauhan1995 Chauhan1997K Chauhan1997e Check1991 Chedid198795 Chedid19909` Chen19909 Cheng19865 Cheng1988H Cheng1994 Chiang199006 Chiappinelli19900 Chiappinelli1991@ Chomcharn1982 Chongsa1985Chougnet19909Chougnet1990Chougnet19910Chougnet19911Chougnet1991Chougnet1992Chougnet19921SChougnet19933mChouteau1994a Chuanak1991 Chulay19879 Chulay19889_ Chulay19901 Chulay1991 Chumpitazi19949( Church19944 Church19955? Church1998h Church19981 Clarke19901 Clavijo1988 Clavijo1990 Clavijo1990 Clavijo1991 Clavijo1991 Clavijo1991Y Clavijo1991j Clavijo1992 Clavijo1992 Clavijo1992_ Clavijo1992 Clavijo1993Z Clavijo1993 Clavijo1997 Clavijo1997b Clavijo1998c Clavijo1998  Clough19859" Clyde1987+ Clyde1989$ Clyde1991 Clyde1992 Clyde1993( Clyde1994: Cochran1988 Cochran1990 Cochran1992% Cochran1992Cochrane19839Cochrane19839!Cochrane19849"Cochrane19849>Cochrane19849Cochrane19849#Cochrane1985 $Cochrane19869JCochrane19872%Cochrane19889kCochrane19889&Cochrane199099Cochrane19909Cochrane1990"Cochrane19919jCochrane19929Cochrane19929Cochrane19939[Cochrane19969 Cohen1993 Cohen1995 Cole19919 Collins1982 Collins1982! 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Sacci1998 Sacci1998 Sacci1998 Sacci1998 Sacci1999 Sacci1999 Sadoff19889l Sadoff1990 Sadoff19900 Sadoff19909 Sadoff19909| Sadoff19919& Sadoff1991I Sadoff19929 Sadoff19933 Sadoff19949 Sadoff1995 Sadoff19966 Sadoff19966h Sadoff19981 Saekhou1997 Saekhou1998g Sahoo1991h Sahoo1991 Sailaja1996 Sailaja1997 Sakaguchi1997Sakatoku19959` Sakhuja1990 Sakhuja1993w Salako1995 Saloui19988 Sampath1992T Samuel19919G San1991 San Roman1992Santroni19905Satchidanandam1991Satchidanandam1991 Sattabongkot1989@ Sattabongkot1990@ Sattabongkot1994 Sattabongkot19959< Satterthwait19900 Sauerwein1991 Sauerwein1991 Saul19911; Saul19929H Saul19944I Saul19954 Saul1998tSaunders19844 Savel1990 Savel1990 Savel1991 Savel1991, Scaife19844 Scalzo19999Scheller19979)Scheller19974LScheraga19869Schiffer19959M Schlesinger1983 Schlesinger1984  Schlesinger1985 Schlesinger1985 Schlesinger1988 Schlumbom1989 Schmid19999> Schmidt1984A Schmidt1986 Schmidt-Ott1999 Schneider1984 Schneider1985 Schneider1987 Schneider1987 Schneider1991I Schneider1992 Schneider1992 Schneider1993( Schneider1994 Schneider1995= Schneider1995 Schneider1998 Schneider1998 Schneider1998 Schneider1999 Schneider2000 Schofield1990 Schofield1990 Schdel1994 Schultheiss1996 Schultz1997Schwartz19877Schwartz1989nSchwartz1991nu Schwarz1987 Schwenk1998Z Sedegah1990997 Robson19959k Rocha1988j Rocha1992 Rocha1993u Rocha1995 Rodrigues1991 Rodrigues1991 Rodrigues1991 Rodrigues1992A Rodrigues1993V Rodrigues1995 Rodrigues19978 Rodriguez19929 Rodriguez1992A Rodriguez1993A Rodriguez1993V Rodriguez1995V Rodriguez1995W Rodriguez1998W Rodriguez1998 Rogers19929 Rogers19929O Rogers19969 Roggero1994 Roggero1995C Roggero1996D Roggero1997 Romero19871 Romero1988 Romero19919 Romero1991(2 Romero19929 Romero1992 Romero19929 Romero19949z Romero19955z Romero19955 Romi19941 Romi1996l Rongnoparut1995b Rose19988c Rose19988 Rosenberg1989 Rosenberg1990 Rosenberg1990{ Rosenberg1992 Rosenberg1995F Rosenbloom19878 Rossan19966 Rossan19977z Rossi1987Rothbard19859 Rotigliano199239 Rowland1992 Rudin1992' Ruebush1989( Ruebush1990 Ruebush1991 Ruebush1993 Ruegg1990 Ruiz19859 Ruiz19860 Ruiz19878 Rungruang1995 Russo1989@ Ruvolo19939z Sabatinelli1987 Sabatinelli1994 Sabatinelli1996 Sacci1997? Sacci1998 Sadoff19889l Sadoff1990 Sadoff19900 Sadoff19909 Sadoff19909| Sadoff19919& Sadoff1991I Sadoff19929 Sadoff19933 Sadoff19949 Sadoff1995 Sadoff19966h Sadoff19981g Sahoo1991h Sahoo1991 Sailaja1996 Sailaja1997 Sakaguchi1997Sakatoku19959` Sakhuja1990 Sakhuja1993w Salako1995 Sampath1992T Samuel19919G San1991 San Roman1992Santroni19905Satchidanandam1991Satchidanandam1991 Sattabongkot1989@ Sattabongkot1990@ Sattabongkot1994 Sattabongkot19959< Satterthwait19900 Sauerwein1991 Sauerwein1991 Saul19911; Saul19929H Saul19944I Saul19954Saunders19844 Savel1990 Savel1990 Savel1991 Savel1991, Scaife19844Scheller19979)Scheller19974LScheraga19869Schiffer19959M Schlesinger1983 Schlesinger1984  Schlesinger1985 Schlesinger1985 Schlesinger1988 Schlumbom1989> Schmidt1984A Schmidt1986 Schneider1984 Schneider1985 Schneider1987 Schneider1987 Schneider1991I Schneider1992 Schneider1993( Schneider1994 Schneider1995= Schneider1995 Schneider1998 Schofield1990 Schofield1990 Schdel1994Schwartz19877Schwartz1989nSchwartz1991nu Schwarz1987Z Sedegah1990AETBDCxBA@?>,PJEnea, V. 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We demonstrate in Aotus monkeys that an intradermal route of immunization with a PyCSP plasmid DNA vaccine generates antibody responses equivalent to a multiple antigen peptide/adjuvant-based vaccine, and that these data support the use of the intradermal route for initial studies of the efficacy of DNA vaccines in inducing protective antibodies against P. falciparum antigens in Aotus monkeys.V ZNY X W"VrXbJackson, K. Hoffman, S.L. Gordon, D.M. Levine, M.M. Edelman, R.R. 1991ϰHEdelman, R.. ϐHadiated malasporozoites: Humoral and cellular responses of the protected individualsAm. J. Trop. Med. Hyg.455*539-54781American Journal of Tropical Medicine and Hygiene*0`ΰ.'Greenwood, J. Willis, A.E. Perham, R.N. 1991Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigensm S h  J. Mol. Biol.V 2204821-827"Journal of Molecular BiologyvoGrifantini, R. Finco, O. Bartolini, E. Draghi, M. Delgiudice, G. Kocken, C. Thomas, A. Abrignani, S. Grandi, G. 1998|vMulti-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmidEur. J. Immunol.284 1225-1232$European Journal of ImmunologyzGrillot, D. Michel, M. Mller, I. Tougne, C. Rnia, L. Mazier, D. Corradin, G. Lambert, P. H. Louis, J. A. Del, Giudice G.|vImmune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii Eur J Immunol 1990206( 1215-12226/Reference Number: 1716; Reference Type: ArticleHAGrillot, D. Pessi, A. Verdini, A.S. Lambert, P.H. Del Giudice, G. 1990 Reduced antibody response to the repetitive sequence of the Plasmodium falciparum circumsporozoite protein in mice infected with Plasmodium yoelii blood forms < Q   Med. Microbiol. Immunol. 1795237-244*#Medical Microbiology and ImmunologyJCGrillot, D. Valmori, D. Lambert, P.-H. Corradin, G. Del Giudice, G. 1993nhPresentation of T-cell epitopes assembled as multiple-antigen peptides to murine and human T lymphocytesInfect. Immun.617t 3064-3067tInfection and Immunity`YGuttinger, M. Caspers, P. Takacs, B. Trzeciak, A. Gillessen, D. Pink, J.R. Sinigaglia, F. 1988|uHuman T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein EMBO J7  2555-2558  0797 Ref11f_Haeseleer, F. Pollet, J.-F. Haumont, M. Dubeaux, C. Bollen, A. Jacobs, P. Modesti, M. Cohen, J.+ 1993cStable integration and expression of Plasmodium falciparum antigen coding sequences in Mycobacteria % :  :3Ginsberg, H.S. Brown, F. Chanock, R.M. Lerner, R.A. Vaccines 93 Cold Spring Harbor $Cold Spring Harbor Lab. Press.413-417 Pf CSP MalMol>7Hamilton, A. J. Suhrbier, A. Nicholas, J. Sinden, R. E. 1988Immunoelectron microscopic localization of circumsporozoite antigen in the differentiating exoerythrocytic trophozoite of Plasmodium bergheiCell Biol Int Rep12123-129 0819 Ref112+Hamilton, A. J. Davies, C. S. Sinden, R. E. 1988Expression of circumsporozoite proteins revealed in situ in the mosquito stages of Plasmodium berghei by the Lowicryl-immunogold technique Parasitology96273-280 0667 Ref11F@Hanke, T. Schneider, J. Gilbert, S.C. Hill, A.V.S. McMichael, A. 1998XDNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice + @ Vaccine164426-435.Vaccine& Pf VaccDNA CSP STARP TRAP HIV.vpHedstrom, R. C. Campbell, J. R. Leef, M. L. Charoenvit, Y. Carter, M. Sedegah, M. Beaudoin, R. L. Hoffman, S. L. 1990VOA malaria sporozoite surface antigen distinct from the circumsporozoite protein*Bull Who68152-157 [5 Cooper19881Copeland1996a Cordey199192 Cordey19929 Cordey19929[ Coreo19961NCornette198793Corradin19869VCorradin19909Corradin19900Corradin19919nCorradin19919{Corradin19915Corradin19911Corradin1991@ECorradin19929[Corradin19929Corradin19929Corradin19921Corradin1992aCorradin19922Corradin19939RCorradin19933|Corradin1993Corradin19944 Corradin19947Corradin19944GCorradin1995zCorradin19955Corradin1995zCorradin19959CCorradin1996rPCorradin19966Corradin1996@Corradin19969Corradin19972!Corradin19977DCorradin1997rKCorradin1997x?Corradin1998Corradin1999Corradin19991Q Cortes19979$ Cortese1991 Cortese1992"Cortesia19878 Costantino199228 Cot1990 Coulanges1990 Coulanges1990 Coulanges1991 Cowman19955 Cox1998 Cox1999Crisanti1998Crisanti19999 Croes1992hCrutcher19989 Cryz19889 Cryz19888I Cryz19922 Cryz19966 Currier1992 Currier1993 Curtis19988 Da19911e Dale19979 Daly1996t Dame19849Daniel-Ribeiro1992iDaniel-Ribeiro19929Daniel-Ribeiro19959Y Davies19888x Davies19900" Davis1987+ Davis1989T Davis1991$ Davis1991Y Davis1991 Davis1992_ Davis1992 Davis1993Z Davis1993 Davis1994( Davis1994 Davis1999o de19877Q de19889p de19888q de19888,de Groot19898- de la Cruz19869. de la Cruz19879/ de la Cruz198790 de la Cruz198891 de la Cruz19889r de la Cruz19888N de la Cruz19882 de la Cruz19899 de la Cruz1989t? de la Vega1998 de Oliveira1993 de Plata19947!De Plata19977 De Taisne1996h de Taisne1998 de Taisne1998Dearruda1990"4 Degremont1987s DeGroot1989Dekumyoy19858Dekumyoy19868 del1987V Del1990 Del19923 Del Giudice19864 Del Giudice19875 Del Giudice19886 Del Giudice1990 Del Giudice1990 Del Giudice1990 Del Giudice1991E Del Giudice1991n Del Giudice1991{ Del Giudice1991 Del Giudice1991 Del Giudice1992 Del Giudice1993l Del Giudice1993| Del Giudice1993 del Guercio1997Del Nero199297 del Portillo19870 Delchambre1999 Delgiudice1998 DelGuercio1999 Deloron1989 Deloron19908 Deloron1990 Deloron1990 Deloron1991 Deloron1991 Deloron1991 Deloron1992S Deloron1993r Deloron1993 Deloron1994 Deloron1999 Demotz19999 Deodhar1992 Deodhar1996[ Deplata1992_ Derks1990 Deslandes1995 Deutch19922 Dgano19999 Dgano2000 di19877& Di1990 Di1990 Di Cristina19999 di Giovanni1990qdi Santi1992X Diallo19969 Diallo19999 Diggs1984 Diggs1987 Diggs1987@Dimayuga1993@~ do19922_ Do Rosario19900 do Rosario19932 Doherty1999: Dontfraid1988 Doolan19912; Doolan19928 Doolan19929 Doolan1993 Doolan1994 Doolan1996 Doolan19966 Doolan1996 Doolan19976 Doolan19971 Doolan19979) Doolan19977* Doolan19977 Doolan1997 Doolan1997 Doolan19989 Doolan1998 Doolan1998 Doran1988 Doran1988 Dowler19988 Draghi19989 Druilhe1995 Druilhe1995 Druilhe1996 Dubeaux1993C Duombo19966 Duque1998 Dutra1990 Dutra1991 Dutra1991< Dyson1990# E.19859 Eberl1992z Eberl1995 Eberl1999 Echeverria1992$ Eddy19919# Edelman1991$ Edelman1991Y Edelman1991% Edelman1992_ Edelman1992 Edelman1993Z Edelman1993( Edelman1994i Eden1986 Egan19877| Egan19911 Egan1991l Egan1993= Eichinger1986 Eichinger1997 Elliott1999M Ellis1983 Ellis1983? Ellis1984 Emery1998> Enea1984i? Enea1984i Enea1985i@ Enea1985i= Enea1986iA Enea1986i7 Enea1987iJ Enea1987i Enea1987iB Enea1988i) Enea19909* Enea1990o9 Enea19901 Enea1990i3 Engers198664 Engers1987 Escalante1995[ Escobar1992 Esko19969 Esko19979zEsposito19878CEsposito1988 DEsposito19899Esposito19905Esposito19929Esposito1995zXEsposito19969Esposito1999Esposito19991A Esteban1993V Esteban1995W Esteban1998Etlinger19889Etlinger19888Etlinger19899Etlinger19919Etlinger19919Etlinger1991Etlinger19929Etlinger1993 Eyal19921 F$urer19881Falcioni19909Fallarme19989 Fang1994a Fang19979 Fang19979 Fang19989h Farley19981E Fasel1992 Fasel1994 Fasel1995 Felix1987" Felix1987> Felix1993 Feny1994 Fern19921 Fernandes19978 Fernandez1992 Fernex19898 Fernex19929Ferreira19859Ferreira19859Ferreira-da-Cruz19922Ferreira-da-Cruz1995 Fidock1995s Fikes1998 Filippi1995(Filipski19900 Finco1998 Finlay1997( Finlay1997Flanagan19999Flanagan19999F Folena19872 Fontes1991i Fontes19979 Fontes1998 Fontes19999 Forbes19999 Foulds19901 Fouts1994i Framson1986Franois19969 Franke19889G Franke19911d Franke19919H Franke19921 Franke19928 Franke19929 Franke19979 Franke19988 Franke1999 Frazer19909 French1995 Freund1998 Frevert1993 Frevert1994  Frevert1996. Frevert1996 Frevert1996 Frevert1997 Frevert19994 Freyvogel1987I Fries1992 Fuggle1989g Fujii1986 Fujioka1999 G.19869 Gachihi1991AGalinski19869JGalinski19872U Galland1995 Galland1997 Gamage19921y93 303a003c000d018e0208001102ff0c00ffffffff000d0000003c000002080000018e00000000000000a000820001000a003c000d018e020800070000000000093049883ab59cf0390022013e00c100000009ffffffffffffffff0023000000a000c400a100c002d82525445349444943543a5f63760d757365726469637420 2f5f6376206b6e6f776e206e6f74207b7573657264696374202f5f63762032302064696374207075747d69660d5f637620626567696e0d2f6264667b62696e64206465667d62696e64206465660d2f6973446576696365436f6c6f72207b2f63757272656e74636f6c6f7273706163652077686572657b706f702063757272 656e74636f6c6f72737061636520302067657420647570202f44657669636547726179206571206578636820647570202f4465766963655247422065712065786368202f446576696365434d594b206571206f72206f727d7b547d6966656c73657d6264660d2f736574636d796b636f6c6f722077686572657b2f73657463 6d796b636f6c6f7220676574202f6376636d796b2065786368206465667d7b2f6376636d796b7b31207375622034203120726f6c6c20337b3320696e64657820616464206e6567206475702030206c747b706f7020307d69662033203120726f6c6c7d72657065617420736574726762636f6c6f7220706f707d626466207d 6966656c73650d2f7374677b6973446576696365436f6c6f72207b6366206361202f6lkjihTgT<;f:fe&98d7l65V4.'Jelinek, T. Lscher, T. Nothdurft, H.D. 1996High prevalence of antibodies against circumsporozoite antigen of Plasmodium falciparum without development of symptomatic malaria in travelers returning from sub-Saharan Africa. B W J. Infect. Dis. 1746d 1376-1379$Journal of Infectious Diseases82Jelinek, T. Blml, A. Lscher, T. Nothdurft, H.-D. 1998]Assessing the incidence of infection with Plasmodium falciparum among international travelers * ? Am. J. Trop. Med. Hyg.591 35-3781American Journal of Tropical Medicine and HygieneLFJolivet, M. Lise, L. Gras-Masse, H. Tartar, A. Audibert, F. Chedid, L. 1990XQPolyvalent synthetic vaccines: relationship between T epitopes and immunogenicityVaccinem8 35-40VaccineRKJones, T.R. Yuan, L.F. Marwoto, H.A. Gordon, D.M. Wirtz, R.A. Hoffman, S.L. 1992sLow immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody  ( Am. J. Trop. Med. Hyg.476*837-84381American Journal of Tropical Medicine and HygienegzsJones, T.R. Obaldia, N. Gramzinski, R.A. Charoenvit, Y. Kolodny, N. Kitov, S. Davis, H.L. Krieg, A.M. Hoffman, S.L. 1999zSynthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys m r Vaccine17 23-24u 3065-3071mVaccinenF@Jongwutiwes, S. Tanabe, K. Hughes, M.K. Kanbara, H. Hughes, A.L. 1994cAllelic variation in the circumsporozoite protein of Plasmodium falciparum from Thai field isolates 5 J Am. J. Trop. Med. Hyg.515659-66881American Journal of Tropical Medicine and Hygiene:3Kain, K. C. Keystone, J. Franke, E. D. Lanar, D. E.nXQGlobal distribution of a variant of the circumsporozoite gene of Plasmodium vivax 1991 J Infect Dis 1641208-210TMKain, K.C. Wirtz, R.A. Fernandez, I. Franke, E.D. Rodriguez, M.H. Lanar, D.E. 1992jSerologic and genetic characterization of Plasmodium vivax from whole blood-impregnated filter paper discs * : Am. J. Trop. Med. Hyg.464473-47981American Journal of Tropical Medicine and HygienezsKain, K.C. Brown, A.E. Webster, H.K. Wirtz, R.A. Keystone, J.S. Rodriguez, M.H. Kinahan, J. Rowland, M. Lanar, D.E. 1992]Circumsporozoite genotyping of global isolates of Plasmodium vivax from dried blood specimens^ 2 B J. Clin. Microbiol.*307. 1863-1866& Journal of Clinical Microbiology.(Kalish, M. L. Check, I. J. Hunter, R. L.Murine IgG isotype responses to the Plasmodium cynomolgi circumsporozoite peptide (NAGG)5. I. Effects of carrier, copolymer adjuvants, and lipopolysacchar ide on isotype selection 1991 J Immunol 146u10 3583-35902+Kaur, P. Sharma, P. Kumar, A. Chauhan, V.S. 1990iSynthetic, immunological and structural studies on repeat unit peptides of Plasmodium falciparum antigens< K `  Int. J. Pept. Protein Res.366^515-521<5International Journal of Peptide and Protein Researchg*$Khan, Z. M. Ng, C. Vanderberg, J. P.~wEarly hepatic stages of Plasmodium berghei: release of circumsporozoite protein and host cellular inflammatory response 1992 Infect Immun601m 264-70TNKhusmith, S. Charoenvit, Y. Kumar, S. Sedegah, M. Beaudoin, R.L. Hoffman, S.L. 1991b[Protection against malaria by vaccination with sporozoite surface protein-2 plus CS protein9Science 252 5006715-718ScienceTNKilgus, J. Jardetzky, T. Gorga, J.C. Trzeciak, A. Gillessen, D. Sinigaglia, F. 1991ZTAnalysis of the permissive association of a malaria T cell epitope with DR molecules J. Immunol. 1461307-315uJournal of Immunology Kilombero, Malaria ProjectyThe level of anti-sporozoite antibodies in a highly endemic malaria area and its relationship with exposure to mosquitoess 1992Trans R Soc Trop Med Hyg865499-504 82Kironde, Fas Rao, Kvs Shah, S. Kumar, A. Sahoo, N.Towards the design of heterovalent anti-malaria vaccines: A hybrid immunogen capable of eliciting immune responses to epitopes of circumsporozoite antigens from two different species of the malaria parasite, Plasmodium  1991 Immunology742323-328 <6Kironde, F. A. Rao, K. V. Shah, S. Kumar, A. Sahoo, N.Towards the design of heterovalent anti-malaria vaccines: a hybrid immunogen capable of eliciting immune responses to epitopes of circumsporozoite antigens from two different species of the malaria parasite, Plasmodium 1991 Immunology742u 323-8f_Kitua, A.Y. Urassa, H. Wechsler, M. Smith, T. Vounatsou, P. Weiss, N.A. Alonso, P.L. Tanner, M. 1999 Antibodies against Plasmodium falciparum vaccine candidates in infants in an area of intense and perennial transmission: relationships with clinical malaria and with entomological inoculation ratesU  ( Parasite Immunol.216307-317 Parasite Immunology 6/Klinman, D.M. Conover, J. Bloom, E.T. Weiss, W. 1998@9Immunogenicity and efficacy of a DNA vaccine in aged mice J. Gerontol. -Biol. Sci.534 B281-B286RKJournals of Gerontology Series A - Biological Sciences and Medical Sciences@:Kobayashi, S. Eden, McCutchan F. Framson, P. Bornstein, P. 1986Partial amino acid sequence of human thrombospondin as determined by analysis of cDNA clones: homology to malarial circumsporozoite proteins Biochemistry25 8418-8425$ 0354 Ref11i|Kremsner, P. G. Neifer, S. Zotter, G. M. Bienzle, U. Rocha, R. M. Maracic, M. Clavijo, P. Nussenzweig, R. S. Cochrane, A. H.Prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites, including a variant of Plasmodium vivax, in the population of two epidemiologically distinct areas in the state of Acre, Brazil 1992Trans R Soc Trop Med Hyg861 23-7ngKrettli, A. U. Rocha, E. M. Lopes, J. D. Carneiro, C. R. Kamboj, K. K. Cochrane, A.H. Nussenzweig, R.S. 1988`YCircumsporozoite protein of Plasmodium gallinaceum characterized by monoclonal antibodiesParasite Immunol10523-533 0851 Ref11`ZKrzych, U. White, K. Link, H. T. Sadoff, J. Lanar, D. Ballou, W. R. Jareed, T. Agarwal, A.jcRole of circumsporozoite protein-specific T-cells in protective immunity against Plasmodium berghei  1990Bull Who6888 88-9388c<|dP8cRX8!P|N  ,@,8H |,PA؀,8| ,d|88`8N |!ax8ax8c4,A2,Ahax8H`caxHV5Aaxc;28H0qA,@lx8: KAy`|~x4,A88|x8FHxF H2EAHx8: KA`|~x4|@\8aBBHAaBH@AT`?A$8`KY`888H$8`K9`HHeA ax8H`caxHTAa8h8!`|N N |!a |x8bc88a clHi` cxhlHTyA|`5 d8|&T8a8X8!P|N |!ahl;bx88:8"%alH`cxl8:HSAa8X8!P|| Hollingdale1986\ Hollingdale1986 Hollingdale1987^ Hollingdale1987 Hollingdale1987 Hollingdale1987 Hollingdale1987" Hollingdale1987 Hollingdale1988  Hollingdale1989 Hollingdale1989_ Hollingdale1990` Hollingdale1990 Hollingdale1991 Hollingdale1991# Hollingdale1991$ Hollingdale1991 Hollingdale1992 Hollingdale1993+ Hollingdale1993 Hollingdale1993 Hollingdale1993( Hollingdale1994 Hollingdale1995= Hollingdale1995 Hollingdale1995 Hollingdale1996 Holloway1999j Holt19929 Hone19900 Hone19941, Hope1984h Horii1998-Hosmalin1992:Houghten19888OHoughten19887nHoughten19889Houghten19908Houghten1990@|Houghten19912Houghten19911Houghten1992-Houghten1992Houghten1992Houghten19922Houghten1993GHoughten1995 Howard1987 Howard19909H Huang1994} Hudson1997a Hughes19910- Hughes199297 Hughes19947 Hughes19944 Hughes19949 Hughes1998 Hui1996e Hunter19919T Hunter19922U Hunter19955 Hunter19959x Hunter19966 Hunter19971y Hunter19977 Hunter19977? Hunter19989 Hurt19969. Hgel1996, Hyde19849 Ichino19988 Ichino1999 Ichino1999F Inacker1987 Inglis19959 Iseki1991] Isenbarger19896 Ishii1998 Ishii1999 Ishii1999 Isibasi1994/ Ivanov1991/ Ivanov199190 Ivanov199190 Ivanov199191 Ivanov199491 Ivanov19949% Jackson1992b Jacobs19910 Jacobs19933 Jaffe1990 Jaffe1990c Jalil1991\ James1992 James1998Q Janse1997 Jarboe19942< Jardetzky1991l Jareed1990m Jareed19920= Jareed1995;2 Jaulin19929T Jegathesan19913 Jelesarov19953 Jelinek19954 Jelinek1996 Jelinek1998yJennings1997 Jiang1998, Johnson1989s Johnson1989 Johnson19925 Jolivet1990 Jones19916 Jones1992( Jones1994 Jones1997 Jones1997 Jones1998 Jones19997 Jongwutiwes1994 Joshi1997 Jue1994 Jue1995 Jue1997y Jue1997 Jue1997 Jue1998 Jung1991r Just1989 Just1992 Kabilan1996 Kager1998d Kain19918 Kain199299 Kain1992 Kain19929 Kain2000le Kalish19919T Kalish19923$ Kamboj19868% Kamboj19888k Kamboj19888 Kamboj1996dk Kamradt19917 Kanbara1994L Kanbara1996 Kang19959Karwacki19888 Kaslow1996h Kaslow19981Kauffman19969: Kaur1990 Kaur19988 Kawashima1999 Kayibanda1998n Keister1988 Keister1988 Keogh1997h Kester19981 Kester1998 Kester19999 Kester19999 Ketrangsri1991D Kettner1997dKeystone199119Keystone1992@ Khamboonruang1993 Khamboonruang1994f Khan19929 Khoromana1994;Khusmith1991aKibatala1996 Kilgus19889< Kilgus1991 Kilombero19929 Kinahan1992g Kironde1991h Kironde1991O Kissinger1996? Kitov1998 Kitov1999 Kitua1999) Klinman1997 Klinman1998 Klinman1998 Klinman1998 Klinman1999 Klinman1999: Knell1988 Knorr1991i Kobayashi1986 Kocken19981 Kocken1999 Koech1992 Koff19966 Koide1999C Koita1996? Kolodny1998 Kolodny1999 Kondo1988v Konishi1996 Koster199092 Kourilsky1992 Koutsoukos1999 Krausa19955jKremsner19926Kremsner19999k Krettli1988 Krettli1991 Krettli1992 Krettli1993u Krettli1995O Krettli1996 Krettli1997 Krettli1998 Krettli1999 Krieg1999Krinchai19919l Krzych1990 Krzych19911m Krzych19920B Krzych1993 Krzych19942 Krzych19959= Krzych1995; Krzych1996h Krzych19981 Krzych1998 Kubo1997 Kuebler1996: Kumar1988n Kumar1988 Kumar1988R Kumar1989 Kumar1990: Kumar1990g Kumar1991h Kumar1991; Kumar1991- Kumar1992 Kumar1994 Kumar1997) Kumar1997h Kumar1998 Kumar1998 Kumar1998 Kumar1999 Kumar1999 Kumar1999 Kwakye-Berko1992 Kwiatkowski1998 La Rosa1992LaChance19955. Lal1987/ Lal1987o Lal19870 Lal19881 Lal1988p Lal1988q Lal1988r Lal1988 Lal1989s Lal1991p Lal1991~ Lal1992q Lal1992 Lal1992 Lal1993r Lal1993 Lal1993 Lal1994 Lal1994 Lal1995x Lal1996 Lal1997y Lal1997 Lal1997 Lal1997 Lal1997 Lal1998 Lal1999 Lalvani1995 Lalvani1996h Lalvani1998 Lalvani19993 Lambert19864 Lambert19876 Lambert1990V Lambert1990 Lambert1990 Lambert1990 Lambert1991E Lambert1991n Lambert1991 Lambert1991 Lambert1992 Lambert1993l Lambert1993| Lambert1993T Lambros1991> Lambros1993zLamizana19878CLamizana1988 Lamizana19929 Lanar1989l Lanar1990t Lanar1990d Lanar19918 Lanar19929 Lanar1992 Lanar1996h Lanar1998 Lanar1998K Law1990 Law1990 Layton19977 Layton19989) Le19979? Le1998 Le19981 Le19999 Le1999m Le1999mT Lee1991 Lee1999 Lee1999Z Leef19901 Leef19919Leentvaar-Kuijpers1998' Lees19939 Lehman1999 Leitner1997 Lekmak1995a_ Leland1990 Leland1993 Lell1999> Lema19939 Lepers19900 Lepers19900 Lepers19919 Lepers19919 Lepers19919S Lepers19939< Lerner1990t" Levine1987+ Levine19891# Levine19911$ Levine1991 Levine19929% Levine19922 Levine19944@ Levitt1993( Lew1999T Lewis1991A Li19931O Li19961 Li1996 Li19966 Liljeqvist1999 Limsomwong19883 Lindsay1990l Link19900m Link19929B Link19939v Linthicum19965 Lise19909> Liu1993 Livingston1998u Lockyer1987v Lockyer1988w Lockyer1989x Lockyer1990y Lockyer1991 Loffl1991zLombardi19878CLombardi1988 Lombardi19909Lombardi19929I Long19922 Long1996t Longta19959m Loomis19920k Lopes1988 Lopes1993 Lopez1995C Lopez1996"Losonsky19878#Losonsky19919$Losonsky19919%Losonsky19929Losonsky19947(Losonsky199496 Louis1990V Louis1990 Louis1990 Louis1991E Louis1991 Louis1992x Louis-Wileman1996y Louis-Wileman1997 Lowell19889 Lowell19909 Lowell199193 Lscher19954 Lscher1996 Lscher1998D Lpez1997 Lu1990 Lu1993356c73650d0023000000a000ab00610098011d00b6013bffec002800070002000200220098012b00ee00a000ad0007000000000009000000000000000000230000002|{E"DCzdyxwvuBA@t`YLeitner, W.W. Seguin, M.C. Ballou, W.R. Seitz, J.P. Schultz, A.M. Sheehy, M.J. Lyon, J.A. 1997Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites    J. Immunol. 15912 6112-6119Journal of Immunology-,&Levitt, A. Dimayuga, F.O. Ruvolo, V.R. 1993TNAnalysis of malarial transcripts using cDNA-Directed polymerase chain reaction J. Parasitol.0795 653-663Journal of ParasitologyA polymerase chain reaction (PCR)-based approach is being employed to study RNA transcripts in malarial parasites, a system that is not easily amenable to molecular studies. Our aim is to compare messages from different life cycle stages to determine whether regulatory information is encoded in the structure of plasmodial transcripts as a result of differential RNA processing. In particular, we have analyzed the structure of the message encoding the circumsporozoite (CS) protein of the murine malaria Plasmodium berghei, the immunodominant surface antigen of the infectious stage of the parasite. Our major findings are that a subset of the CS message utilizes multiple polyadenylation sites, that some processed CS transcripts are found in blood-stage parasites, and that the 5' untranslated region of the message is unusually long and has multiple start sites. Moreover, repetitive motifs that may represent enhancers or transcriptional binding sites are present upstream of the transcription unit. In addition, we describe details of the cDNA-directed PCR procedure that may be helpful to other parasitologists who work with small, unpurified biological samples.nhLi, S.Q. Rodrigues, M. Rodriguez, D. Rodriguez, J.R. Esteban, M. Palese, P. Nussenzweig, R.S. Zavala, F. 1993Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria m  n  Proc. Natl. Acad. Sci. USA9011 5214-5218VOProceedings of the National Academy of Sciences of the United States of America&Link, H.T. White, K. Krzych, U. 1993]Plasmodium berghei-specific T cells respond to non-processed sporozoites presented by B cellsm  Eur. J. Immunol.239 2263-2269$European Journal of Immunology"Lockyer, M.J. Schwarz, R.T. 1987TNStrain variation in the circumsporozoite protein gene of Plasmodium falciparumMol Biochem Parasitol22101-108 0979 Ref11 Lockyer, M.J. 1988|The 5' coding region of the Plasmodium falciparum circumsporozoite protein gene is a focus for deletion and insertion events Nuc Acids Res1618 9041 0978 Ref11.'Lockyer, M. J. Marsh, K. Newbold, C. 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Luescher, I.F. 1994VEfficient in vivo induction of CTL by cell-associated covalent H-2Kd-peptide complexes C  D J. Immunol. Methods 1711 73-84.& Journal of Immunological Methods`ZRomi, R. Sabatinelli, G. Majori, G. Ralamboranto, L. Raveloarifera, F. Ranaivoharimina, H. 1994Plasmodium falciparum circumsporozoite antibody prevalence in Madagascar: a longitudinal study in three different epidemiologic areas  Am. J. Trop. Med. Hyg.516856-86381American Journal of Tropical Medicine and HygieneF?Romieu, R. Baratin, M. Kayibanda, M. Guillet, J.-G. Viguier, M. 1998XIFN-g-secreting Th cells regulate both the frequency and avidity of epitope-specific CD8+ T lymphocytes induced by peptide immunization: an ex vivo analysis     @  X  Y    Int. Immunol.4109g 1273-1279.International ImmunologyPJRongnoparut, P. Supsamran, N. Sattabongkot, J. Suwanabun, N. Rosenberg, R. 1995aPhenotype and genotype diversity in the circumsporozoite proteins of Plasmodium vivax in Thailand E U Mol. Biochem. 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Immunol. 150,4 1471-1478Journal of Immunology Py CSP MalLyMAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA HEPATIC STAGES; CD8+ LYMPHOCYTES-T; MONOCLONAL-ANTIBODIES; GAMMA-INTERFERON; IMMUNIZED VOLUNTEER; INHIBITORY ACTIVITY; MURINE MALARIA; CS PROTEIN; CLASS-IPreviously, CD4+ T cell lines and clones were isolated after immunization of BALB/c and C57BL/6 mice with the Py1 peptide, a 21-mer synthetic peptide corresponding to a N-terminal segment of the circumsporozoite protein of Plasmodium yoelii. The clones were separated into the Th1 and Th2 subsets on the basis of lymphokine production. It was observed that immunization with the Py1 peptide induced preferentially Th1 cells in BALB/c and Th2 cells in C57BL/6 mice. These clones were then tested for their cytolytic ability in vitro. Some of the clones from BALB/c and C57BL/6 mice eliminated liver stage parasites from cultured hepatocytes in a MHC restricted manner. 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Ayala, F.J. 1998YThe recent origin of allelic variation in antigenic determinants of Plasmodium falciparum D Genetics 150m1515-517Genetics{Rickman, L. S. Gordon, D. M. Wistar, R. Jr Krzych, U. Gross, M. Hollingdale, M. R. Egan, J. E. Chulay, J. D. Hoffman, S. L.6Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine 1991 Lancet 337c 8748998-1001tmRiley, E. M. Allen, S. J. Bennett, S. Thomas, P. J. O'Donnell, A. Lindsay, S. W. Good, M. F. Greenwood, B. M.dRecognition of dominant T cell-stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian childrenTrans R Soc Trop Med Hyg 1990845B648-657J6/Reference Number: 4302; Reference Type: ArticleRitu, G. Rao, D.N. 1992tConstruction of synthetic immunogens: Use of T- and B-cell epitopes of CS and RESA proteins of Plasmodium falciparum _ Vaccine1011761-765Vaccine Cryz, Sj Jr Ballou, R. 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Microbiol. 426705-708("Journal of Eukaryotic Microbiology Pgal MalMab sporoz CSP h Abok19969 Abrignani1998 Adams1988 Adoyo-Adoyo1991 Afari1995l Agarwal1990Aggarwal19900Aggarwal1990 Aguiar19969* Aguiar19977 Aguiar19988 Ahlborg1999 Aidoo1995 Aidoo1996 Aidoo1997 Aidoo1998 Aikawa1980 Aikawa19878 Aikawa19898 Aikawa19899& Aikawa19900` Aikawa1990 Aikawa19911 Aikawa19959 Ak1993BAkanmori19959 Alexander1997 Alexander1998 Alexander1999 Aley1986 Aley1987^ Aley19878 Aley19871 Aley19898 Allen1990O Alling19888s Alling19899 Allsopp1995 Allsopp1997 Alonso19999p Alpers19919 Alpers19921q Alpers19929 Alpers19926r Alpers19939 Alpers1993 Alpers19999 Altaba1987Q Altszuler1997 Alving1990 Alving19959? Alving19989Ambroise-Thomas1994h Anders19989Andersen1997/ Andronova19910 Andronova19911 Andronova1994 Anker1990 Anumudu1998 Appel1992 Appella1997 Appella1997 Appella1998 Appella1999_ Appiah1990 Arad1990oArdeshir19909CArevalo-Herrera1996!Arvalo-Herrera1997DArvalo-Herrera1997Arvalo-Herrera1998 Armah1988  Armah1990 Arnon1985> Arnot1984? Arnot1984  Arnot1985= Arnot1986J Arnot1987  Arnot1988B Arnot1988  Arnot1990 Arnot1993 Arnot1994 Arreaza1991 Arrhenius1997? Asavanich1984 Asavanich1985 Asavanich1986 Astagneau1990 Astagneau1991 Astagneau1991 Astagneau1994Atkinson1987n Atkinson19899Atkinson19899Atkinson19959 Audibert198505Audibert19909 Audran1999[ Avila1992 Ayala1995} Ayala1997 Ayala1998 Bai1997 Bales1996 Ballou19859 Ballou19859\ Ballou19866^ Ballou1987 Ballou19871 Ballou19879 Ballou19878 Ballou19881 Ballou19889' Ballou1989] Ballou19898_ Ballou19901l Ballou1990 Ballou19919m Ballou19920 Ballou19921 Ballou1993 Ballou1995 Ballou19959 Ballou19961 Ballou19966 Ballou19977? Ballou19981h Ballou19989 Ballou19988 Ballou19999 Ballou19991 Bangs1997 Bannwarth1990" Baqar1987+ Baqar1989 Baqar1992 Baratin1998- Barnd1992Barnhart1998 Barnwell19859 Barnwell19850$Barnwell19869JBarnwell19872 Barnwell19889 Barnwell19909 Baron1988 Barr19878 Barr19888 Barr19888( Barr19901# Barr19911 Barr19971Barragan1999 Barrio19959E Barrios1991 Barrios1992 Bartolini1998 Basco1998 Bates1986(Bathurst19909Bathurst19911Bathurst19919Bathurst1991o#Bathurst19919Bathurst19979 Battistutta1989 Bauch1998Baumgart19979 Bayoumi1993Beaudoin19859ZBeaudoin19909_Beaudoin19909Beaudoin19900Beaudoin19919Beaudoin19919;Beaudoin19919Beaudoin1992Beaudoin1993a Beavis19977 Bechara1991 Beck1993u Beck19949 Beck1999 Becker19989 Becker19989E Begdadi1992 Beghdadi-Rais1994$ Beier1991 Beier1991I Beier1992 Beier1993 Beier1993 Beier1993 Bennett19905 Berbiguier19888 Berger19899 Berger19929Bergmann1998E Bernard1992gBernardi1990@k Berriz19911 Bertholet1994 Berzins1999 Berzofsky1986N Berzofsky1987O Berzofsky1988P Berzofsky1988Q Berzofsky1988 Berzofsky1988 Berzofsky1988] Berzofsky1989 Berzofsky1990 Berzofsky1991- Berzofsky1992 Berzofsky1992G Berzofsky1995 Bessler1991 Betschart1988 Betschart1990R Betschart1993z Betschart1995! Bettens1997 Bharadwaj1996 Bharadwaj1997 Bhasin19969 Bhattacharya1999 Bian199666 Bianchi1990n Bianchi1991j Bienzle1992Billetta19917 Bilsborough1993 Bilsborough1994 Bilsborough19974 Biro19878 Bisang19959] Bisang19979 Bisang1998 Biswas1999 Blanchard1998 Blanchard1998 Blanchard1999 Bloom1998Blum-Tirouvanziam1994Blum-Tirouvanziam1995 Blml1998b Bollen19911 Bollen19933 Bonelli19866 Bonelli1990> Bongers1993m Bonnemains1994r Borellini1999i Bornstein1986Bosshard19955 Boudin19922 Boudin19949 Boulanger1988 Boulanger1990mBourreau1994a Boursnell1990 Bower1993 Bltz1991 Brabin19891  !$Root Entry FR)U`|:$&1Table WordDocumentSummaryInformation~P}P|rdey, а0 Widmann, C. Luescher, I.F. Corradin, G. Maryanski, J.L. HMaryanski, J ԠH jdRnia, L. Grillot, D. Marussig, M. Corradin, G. Miltgen, F. Lambert, P.H. Mazier, D. Del Giudice, G. 1993oEffector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages 9  : Q b  J. Immunol. 150,4 1471-1478Journal of Immunology Py CSP MalLyMAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA HEPATIC STAGES; CD8+ LYMPHOCYTES-T; MONOCLONAL-ANTIBODIES; GAMMA-INTERFERON; IMMUNIZED VOLUNTEER; INHIBITORY ACTIVITY; MURINE MALARIA; CS PROTEIN; CLASS-IPreviously, CD4+ T cell lines and clones were isolated after immunization of BALB/c and C57BL/6 mice with the Py1 peptide, a 21-mer synthetic peptide corresponding to a N-terminal segment of the circumsporozoite protein of Plasmodium yoelii. The clones were separated into the Th1 and Th2 subsets on the basis of lymphokine production. It was observed that immunization with the Py1 peptide induced preferentially Th1 cells in BALB/c and Th2 cells in C57BL/6 mice. These clones were then tested for their cytolytic ability in vitro. Some of the clones from BALB/c and C57BL/6 mice eliminated liver stage parasites from cultured hepatocytes in a MHC restricted manner. Nevertheless, none of these clones was able to lyse Py1 peptide-pulsed target cells. it was also found that two clones could protect BALB/c mice against a sporozoite challenge. These results provide evidence that CD4+ T cells, induced after priming with a defined peptide, could participate in the effector mechanisms against malaria liver stages.XvoArticle L Renia, Grp Hosp Pitie Salpetriere, Dept Parasitol, Inserm, U313, 91 Bld Hop, F-75634 Paris 13, France82Rich, K. A. George, F. W. Law, J. L. Martin, W. J. 1990LECell-adhesive motif in Region II of malarial circumsporozoite proteinScience 249 4976 1574-1577 1226 Ref11*#Rich, S.M. Hudson, R.R. Ayala, F.J. 1997RPlasmodium falciparum antigenic diversity: evidence of clonal population structure   Proc. Natl. Acad. Sci. USA9424 13040-13045VOProceedings of the National Academy of Sciences of the United States of America{Rickman, L. S. Gordon, D. M. Wistar, R. Jr Krzych, U. Gross, M. Hollingdale, M. R. Egan, J. E. Chulay, J. D. Hoffman, S. L.6Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine 1991 Lancet 337c 8748998-1001tmRiley, E. M. Allen, S. J. Bennett, S. Thomas, P. J. O'Donnell, A. Lindsay, S. W. Good, M. F. Greenwood, B. M.dRecognition of dominant T cell-stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian childrenTrans R Soc Trop Med Hyg 1990845B648-657J6/Reference Number: 4302; Reference Type: ArticleRitu, G. Rao, D.N. 1992tConstruction of synthetic immunogens: Use of T- and B-cell epitopes of CS and RESA proteins of Plasmodium falciparum _ Vaccine1011761-765Vaccine  8 :  8 |j` ZSShi, Y.P. Udhayakumar, V. Alpers, M.P. Povoa, M.M. Oloo, A. Ruebush, T.K. Lal, A.A. 1993Natural antibody responses against the non-repeat-sequence-based B-cell epitopes of the Plasmodium falciparum circumsporozoite protein X m Infect. 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Epidemiol.171 16-34Genetic EpidemiologyStirnadel, H.A.D 1999The relative contribution of genetic and environmental factors to variation in malaria immunity, infection and related morbidity, in areas highly endemic for Plasmodium falciparum   & University of Basel, Switzerland Ph.D.Stoute, J.A. Kester, K.E. Krzych, U. Wellde, B.T. Hall, T. White, K. Glenn, G. Ockenhouse, C.F. Garcon, N. Schwenk, R. Lanar, D.E. Sun, P. Momin, P. Wirtz, R.A. Golenda, C. Saloui, M. Wortmann, G. Holland, C. Dowler, M. Cohen, J. Ballou, W.R. 1998d]Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine-J. Infect. Dis.  178n4 1139-1144$Journal of Infectious DiseasesD=Stuber, D. Bannwarth, W. Pink, J. R. Meloen, R. H. 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Lal, A.A. 1995Monopalmitic acid-peptide conjugates induce cytotoxic T cell responses against malarial epitopes: importance of spacer amino acidsJ. Immunol. Methods 1822219-226& Journal of Immunological Methods2+Viscomi, G. C. Ziggiotti, A. Verdini, A. S.iPreparative purification of Plasmodium falciparum circumsporozoite protein synthetic polypeptides by displacement chromatography J Chromatogr 1989 482k1 99-106PIVreden, Sgs Verhave, J. P. Oettinger, T. Sauerwein, R. W. Meuwissen, JhetsPhase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen 1991Am J Trop Med Hyg455533-538RLVreden, S. G. Verhave, J. P. Oettinger, T. Sauerwein, R. W. Meuwissen, J. H.Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen 1991Am J Trop Med Hyg455e 533-8 vpWang, R.B. Charoenvit, Y. 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Hoffman, S.L. 1998A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine J. Immunol. 161g5^ 2325-2332Journal of Immunology Py VaccDNA CSP GM-CSFV*#White, K.L. Jarboe, D.L. Krzych, U. 1994^Immunization with irradiated Plasmodium berghei sporozoites induces IL-2 and IFNg but not IL-4  / P Q Parasite Immunol.169479-491Parasite Immunology^*#White, K.L. Snyder, H.L. Krzych, U. 1996MHC class I-dependent presentation of exoerythrocytic antigens to CD8+ T lymphocytes is required for protective immunity against Plasmodium berghei E  F   J. Immunol.d 1569 3374-3381-Journal of ImmunologyF?Widmann, C. Romero, P. Maryanski, J.L. Corradin, G. Valmori, D. 1992voT helper epitopes enhance the cytotoxic response of mice immunized with MHC class I-restricted malaria peptidesuJ. Immunol. Methods 1551 95-99.& Journal of Immunological MethodsRKWiesmller, K. H. Jung, G. Gillessen, D. Loffl, C. Bessler, W. G. 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Lett. 140 2-3209-214 FEMS Microbiology LettersN 88||tc|c.N 88||tc|c.N 88||tc|c.N 88||tc|c.N 88||tc|c.N 88||tc|c.N "88||tc|c.N &88||tc|c.t Nussenzweig1985 Nussenzweig1985 Nussenzweig1985 Nussenzweig1986 Nussenzweig1986$ Nussenzweig1986= Nussenzweig1986A Nussenzweig19867 Nussenzweig1987J Nussenzweig1987z Nussenzweig1987 Nussenzweig1987 Nussenzweig1987 Nussenzweig1987 Nussenzweig1987 Nussenzweig1987 Nussenzweig1987" Nussenzweig1987" Nussenzweig1987C Nussenzweig1988k Nussenzweig1988' Nussenzweig1989f Nussenzweig1989f Nussenzweig1989& Nussenzweig1990( Nussenzweig1990 Nussenzweig1990 Nussenzweig1990 Nussenzweig1990 Nussenzweig1990 Nussenzweig1990 Nussenzweig1990 Nussenzweig1991 Nussenzweig1991 Nussenzweig1991 Nussenzweig1991$ Nussenzweig1991& Nussenzweig1991& Nussenzweig1991 Nussenzweig1991j Nussenzweig1992 Nussenzweig1992 Nussenzweig1992_ Nussenzweig1992 Nussenzweig1992 Nussenzweig1993 Nussenzweig1993A Nussenzweig1993` Nussenzweig1993 Nussenzweig1994a Nussenzweig1995  Nussenzweig1996 Nussenzweig1996Q Nussenzweig1997Q Nussenzweig1997 Nussenzweig1997W Nussenzweig1998c Nussenzweig1998 Nussenzweig1998 Nussenzweig1998 Nussenzweig1999 Nutman19922 Nutman19977g Nuzzolo1990 Nwagwu1998Nyakundi19919 O'Donnell1990 O'Hagan1996 Obaldia1996 Obaldia1997 Obaldia1999 Obi1998 Ochola19922" Ockenhouse19844h Ockenhouse1998;  Ockenhouse1998 Odera1989 Oettinger1991 Oettinger1991L Ohara1996pOliveira1991ZaOliveira1995@cOliveira19989Oliveira-Ferreira1992iOliveira-Ferreira1992Oliveira-Ferreira1995Ologunde1998 Oloo19933 Oloo19969 Oloo19977 Oloo19979U Olsen1995 Omata1990 Ongecha1997 Oo19919 Orago1997 Osanga19898 Oster1991 Oster1996s Otoo19898 Ou19888 Ozaki1983 Ozaki1983 Ozaki1986 Ozaki1987 Ozaki1987 Paiva1991 Paleologo1988A Palese19933W Palese19989 Palomeque1998^ Pancake1987j Pancake1992 Pang19888 Panyim19929Paoletti19969hPaoletti19988( Paparello1994 Parekh19941 Parker1999 Parker1999 Paru19922 Pastor19879Patankar19977 Pathan19999 Pazart19941 Perham19919k Perkins1991! 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Quakyi19849: Quakyi19888O Quakyi19889n Quakyi19880 Quakyi1988d, Quakyi19899s Quakyi1989o Que1988I Que1992 Que1996 Ralamboranto1994( Ralamboranto1996`tRamasamy19941tRamasamy19944u Ramirez1995[ Ramos1996Ranaivoharimina1994 Ranjit1999J Rao1990 4d,A4WLWRW YPRIV''''0 13MDo \\LS2\STI2126 D_ 4d,A4PRIV''''0 13MD \Times New Roman Symbol &ArialPalatino"Helvetica Times"Thr*f++8U@Q:I#dHOECD WORKSHOP MEXICO 96 ON BIOTECHNOLOGY FOR WATER USE AND CONSERVATIONOECDOECDFILE߾j\ resources.doc1 1/27 1oc 1csho 1  ̌   $ JWDBNMSWDj|^^j\WDBNMSWDt $ JWDBNMSWDj|^^j\WDBNMSWDtl2SS p||||cࡱ> <Oh+'0x   ( 4 @ LX`hp PHS 398 (RevoHS  mcculloughgccuNormalu mcculloughg3cuMicrosoft Word 8.0@~@B=:@@p՜.+,D՜.+,D hp  Alfred Hospital %   PHS 398 (Rev Title 6> _PID_GUIDAN{256852B2-0664-11D3-B7A5-0000F81ED142}PHS 398 (Rev. 4/98) (Form Page 8) Page ______ HH FACILITIES: RESO Sedegah1990 Sedegah1991; Sedegah1991 Sedegah1992 Sedegah1992 Sedegah1992 Sedegah1993' Sedegah1994( Sedegah1994 Sedegah1994 Sedegah1995 Sedegah1996 Sedegah1996 Sedegah1996 Sedegah1997 Sedegah1997 Sedegah1997) Sedegah1997* Sedegah1997 Sedegah1998 Sedegah1998 Sedegah1998 Sedegah1998 Seguin19977 Seitz1997T Selvarajan19913 Sethabutr1992 Sette1997 Sette1997 Sette1998 Sette1999g Shah19919h Shah19919 Shakibaei1996 Shakibaei1997 Sharma1985: Sharma1990d Sharma19922 Sharma19951 Sharma19966 Sharma1996 Sharma19979 Sharma1999 Sheehy19977 Sheick19949Sherwood19874Sherwood19916Sherwood1996a Sheu19999 Shi1992r Shi1993 Shi1993 Shi1994 Shi1997  Shi1999 Shorter1991 Shreffler1993 Sidjanski1997 Sidney19979( Silverman1994 Sim1992, Simmons1984c Simon1998` Sina19909 Sina19929 Sina1993l Sina1993l Sina1995l Sina19988X Sinden19888Y Sinden19888 Sinden19888x Sinden19909+ Sinden1993 Sinden19988 Sinden19989 Singh1996 Singh1996W Sinigaglia19883 Sinigaglia1988 Sinigaglia19885 Sinigaglia1990< Sinigaglia1991Z Sinigaglia19938 Sinigaglia19977 Sinnis19933 Sinnis1994 Sinnis19966 Sinnis1996 Sinnis19977 Sinnis19971  Sinnis1998Sirikong1995oX Sirima19969 Sirima19999 Sirima19999 Siu1995( Skinner1990 Skinner1991 Slaoui1995 Slaoui19999 Smith1986N Smith1987k Smith1991% Smith1992- Smith1992 Smith1992 Smith1996 Smith1998 Smith1998 Smith1999 Smith1999 Smith1999 Snyder1996Sodeinde1998 Soldati1999 Sookto1992 Southwood1997w Sowunmi1995 Spano1998 Spillmann1999(Stanfill19900 Sthl1999Steketee19944Stephens1995 Stewart1988 Stewart1988 Stewart1990 Stewart1991 Stewart1992  Stirnadel1999  Stirnadel1999h Stoute19981  Stoute1998 Strand19909 Strickland1996r Stuber19901 Stuber19919 Stber19922 Strchler1989 Strchler1992w Strchler1995s Sugars1989oXSuhrbier19888Suhrbier19880xSuhrbier19908Suhrbier1991@Suhrbier1991Suhrbier19999USullivan19953OSullivan19966Sullivan19979 Sultan1994Q Sultan19979\ Sulzer1992h Sun1998 Sun1998 Sundy1989 Supsamran1995 Suvarnamani1988 Suvarnamani1992 Suwanabun1994 Suwanabun1995M Svec19833 Svec19833 Svec19858 Sweeney1999$ Sztein1991Y Sztein19911Z Sztein19933 Sztein19944( Sztein1994 Tacket19944 Tahar1998W Takacs19888 Takacs19889 Takacs19919 Takacs19919 Takacs19922 Takacs19929 Takacs19939 Takeno19999 Takiguchi1995 Takita-Sonoda1996 Takitasonoda1998 Tallet19900 Tallet19919 Tam1985 Tam1986= Tam1986 Tam1986 Tam1988 Tam1990 Tam1992 Tam19937 Tanabe19944 Tanner19877 Tanner19969 Tanner19999 Tapchaisri19822 Tapchaisri19850 Tapchaisri198605 Tartar19901 Tartar1995J Taylor19969 Tchavtchitch1998 Tegoshi19910 Tertyshnikova1991Thanassi19929 Tharavanij19860 Thomas19900 Thomas19921 Thomas19977 Thomas19981 Thomas19999Thomasin1996@Thomasin1999 Timperman1996 Tine19969h Tine19989 Tine19989 Tine19989 Tirtolusumo19973 Togna1986 Togna1986C Tolle1996 Tomita19889 Tomita1990 Tomita1992( Tomley19901] Torda1997 Tornieporth19994 Tougne19876 Tougne1990V Tougne19900 Tougne1991n Tougne19911 Tougne19921l Tougne19933 Touray19922O Touray19969 Triglia1995Trottein1995@WTrzeciak19888Trzeciak19888Trzeciak19888Trzeciak19911<Trzeciak19911Trzeciak1993 Tsang1987 Tsuji1990 Tsuji1992 Tsuji1996 Tsuji1997W Tsuji1998 Tsuji1998 Tsuji1998Tsutsumi19988Tulyayon19888Tulyayon1992a Tuszynski1992 Uadia1990Uchijima1999 Udhayakumar1993 Udhayakumar1994 Udhayakumar1994 Udhayakumar1995y Udhayakumar1997 Udhayakumar1997 Udhayakumar1997 Udhayakumar1998F Ulrich1993& Uni1990 Urassa1999n Valmori1991 Valmori1992 Valmori1993 2>P4RLWongsrichanalai, C. Webster, H. K. Permpanich, B. Chuanak, N. Ketrangsri, S.zsNaturally acquired circumsporozoite antibodies and their role in protection in endemic falciparum and vivax malariaz 1991Am J Trop Med Hyg442201-204Yang, C.F. Collins, W.E. Xiao, L.H. Saekhou, A.M. Reed, R.C. Nelson, C.O. Hunter, R.L. Jue, D.L. Fang, S.N. Wohlhueter, R.M. Udhayakumar, V. Lal, A.A. 1997RInduction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin & - }  Vaccine154@377-386Vaccine\VYing, P. Shakibaei, M. Patankar, M.S. Clavijo, P. Beavis, R.C. Clark, G.F. Frevert, U. 1997The malaria circumsporozoite protein: interaction of the conserved regions i and II-plus with heparin-like oligosaccharides in heparan sulfateExp. Parasitol.852168-182 Experimental ParasitologyNLFYoshida, N. Nussenzweig, R.S. Potocnjak, P. Nussenzweig, V. Aikawa, M. 1980hbHybridoma produces protective antibodies directed against the sporozoite stage of malaria parasiteScience 207 71-73ScienceHAYoshida, N. del, Portillo Ha di, Santi Sm Nussenzweig, R. S. EneauRKPlasmodium falciparum: epidemiological studies on the circumsporozoite gene Exp Parasitol 198764 510510-513gXQYoshida, N. Di, Santi Sm Dutra, A. P. Nussenzweig, R. S. Nussenzweig, V. Enea, V.urlPlasmodium falciparum: Restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil Exp Parasitolo 1990714 386-39216/Reference Number: 1775; Reference Type: ArticlehHBYoung, J. F. Hockmeyer, W. T. Gross, M. Ballou, W. R. Wirtz, R. A.~Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccineScience 1985 228 958958-962PIZavala, F. Gwadz, R. W. Collins, F. H. Nussenzweig, R. S. Nussenzweig, V. xrMonoclonal antibodies to circumsporozoite proteins identify the species of malaria parasite in infected mosquitoes Nature 1982 299  737 737-738mNHZavala, F. Cochrane, A.H. Nardin, E.H. Nussenzweig, R.S. Nussenzweig, V. 1983yCircumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopesB J Exp Med 157 1947-1957  0409 Ref11&Zavala, F. Tam, J.P. Masuda, A. 1986iSynthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites  H ] J. Immunol. Meth.93 55-61& Journal of Immunological Methods Zavala, F. 1991f`The multifactorial character of the protective immunity induced by immunization with sporozoites Res. Immunol.  142 8\654-658Research in Immunology>7Zevering, J. Houghten, R.A. Frazer, I.H. Good, M.F. 1990`Z Major population differences in T cell response to a malaria sporozoite vaccine candidate Int. Immunol.  2 945-955.International Immunology0)Zevering, Y. Khamboonruang, C. Good, M.F. 1994Natural amino acid polymorphisms of the circumsporozoite protein of Plasmodium falciparum abrogate specific human CD4+ T cell responsiveness D Y u  v Eur. J. Immunol.246- 1418-1425y$European Journal of Immunologye protein OprF as the carrier   FEMS Microbiol. Lett. 140 2-3209-214 FEMS Microbiology LettersRLWongsrichanalai, C. Webster, H. K. Permpanich, B. Chuanak, N. Ketrangsri, S.zsNaturally acquired circumsporozoite antibodies and their role in protection in endemic falciparum and vivax malariaz 1991Am J Trop Med Hyg442201-204Yang, C.F. Collins, W.E. Xiao, L.H. Saekhou, A.M. Reed, R.C. Nelson, C.O. Hunter, R.L. Jue, D.L. Fang, S.N. Wohlhueter, R.M. Udhayakumar, V. Lal, A.A. 1997RInduction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin & - }  Vaccine154@377-386Vaccine\VYing, P. Shakibaei, M. Patankar, M.S. Clavijo, P. Beavis, R.C. Clark, G.F. Frevert, U. 1997The malaria circumsporozoite protein: interaction of the conserved regions i and II-plus with heparin-like oligosaccharides in heparan sulfateExp. Parasitol.852168-182 Experimental ParasitologyNLFYoshida, N. Nussenzweig, R.S. Potocnjak, P. Nussenzweig, V. Aikawa, M. 1980hbHybridoma produces protective antibodies directed against the sporozoite stage of malaria parasiteScience 207 71-73ScienceHAYoshida, N. del, Portillo Ha di, Santi Sm Nussenzweig, R. S. EneauRKPlasmodium falciparum: epidemiological studies on the circumsporozoite gene Exp Parasitol 198764 510510-513gXQYoshida, N. Di, Santi Sm Dutra, A. P. Nussenzweig, R. S. Nussenzweig, V. Enea, V.urlPlasmodium falciparum: Restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil Exp Parasitolo 1990714 386-39216/Reference Number: 1775; Reference Type: ArticlehHBYoung, J. F. Hockmeyer, W. T. Gross, M. Ballou, W. R. Wirtz, R. 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Immunol.  142 8\654-658Research in Immunology>7Zevering, J. Houghten, R.A. Frazer, I.H. Good, M.F. 1990`Z Major population differences in T cell response to a malaria sporozoite vaccine candidate Int. Immunol.  2 945-955.International Immunology0)Zevering, Y. Khamboonruang, C. Good, M.F. 1994Natural amino acid polymorphisms of the circumsporozoite protein of Plasmodium falciparum abrogate specific human CD4+ T cell responsiveness D Y u  v Eur. J. Immunol.246- 1418-1425y$European Journal of Immunology@8`N 888H(f|@A@ 8`N 8`N 4@8`N ( T>8A|TA|(P4@(ATTT@.|`x|x|xT8A,4@TA4@8T(M 4@N bN 8888bU,%@08f N 8(9 Ad9YlT:}.} N 8HH!H@(A48H(!H (A8H9 , A K,* >*  Aguiar, J.C. Ahlborg, N. Aidoo, M. Alexander, J. Alonso, P.L. Alpers, M.P. Anumudu, C.A. Appella, E.Arvalo-Herrera, M. Arnot, D.E. Audran, R. Ayala, F.J. Ballou, W.R. Baratin, M. Barnhart, K. Barragan, A. Barrios, C. Basco, L.K. Bauch, C.Bayoumi, R.A.L. Beck, H.-P. Becker, M.Bergmann, C.C. Berzins, K.Bhattacharya, P.R. Bian, Z.N. Bisang, C. 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