The Walter and Eliza Hall Institute of Medical Research

2008-2009 Research Publications

Key

ATD Autoimmunity and Transplantation Division
BIO Bioinformatics Division
CHD Cancer and Haematology Division
INF Infection and Immunity Division
IMM Immunology Division
JPS Joint ProteomicS Laboratory
MGC Molecular Genetics of Cancer Division
MMD Molecular Medicine Division
SBD Structural Biology Division

Number of Publications

Primary: 184
Reviews: 54
Edited Book: 1
Chapters: 7
Total: 246

Primary

Adams TE, Koziolek EJ, Hoyne PH, Bentley JD, Lu L, Lovrecz G, Ward CW, Lee FT, Scott AM, Nash AD, Rothacker J, Nice EC, Burgess AW, Johns TG. A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo. Growth Factors 27:141-154, 2009 SBD

Adda CG, Murphy VJ, Sunde M, Waddington LJ, Schloegel J, Talbo GH, Vingas K, Kienzle V, Masciantonio R, Howlett GJ, Hodder AN, Foley M, Anders RF. Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils. Mol Biochem Parasitol 166:159-171, 2009 INF

Arnold JM, Choong DY, Thompson ER, kConFAB, Waddell N, Lindeman GJ, Visvader JE, Campbell IG, Chenevix-Trench G. Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors. Breast Cancer Res Treat Feb 3, 2009 (Epub ahead of print) MGC

Ashe A, Morgan DK, Whitelaw NC, Bruxner TJ, Vickaryous NK, Cox LL, Butterfield NC, Wicking C, Blewitt ME, Wilkins SJ, Anderson GJ, Cox TC, Whitelaw E. A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol 9:R182, 2008 MMD

Augstein P, Heinke P, Salzsieder E, Grimm R, Giebel J, Salzsieder C, Harrison LC. Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1. Diab Vasc Dis Res 5:198-204, 2008 ATD

Babon JJ, Sabo JK, Zhang JG, Nicola NA, Norton RS. The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol 387:162-174, 2009 SBD CHD

Bahlo M, Bromhead CJ. Generating linkage mapping files from Affymetrix SNP chip data. Bioinformatics May 12, 2009 (Epub ahead of print) BIO

Baker MJ, Webb CT, Stroud DA, Palmer CS, Frazier AE, Guiard B, Chacinska A, Gulbis JM, Ryan MT. Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell 20:769-779, 2009 SBD

Baldwin GS, Bailey MF, Shehan BP, Sims I, Norton RS. Tyrosine modification enhances metal-ion binding. Biochem J 416:77-84, 2008 SBD

Ball LJ, Levy N, Zhao X, Griffin C, Tagliaferri M, Cohen I, Ricke WA, Speed TP, Firestone GL, Leitman DC. Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements. Mol Cell Endocrinol 299:204-211, 2009 BIO

Barker HE, Smyth GK, Wettenhall J, Ward TA, Bath ML, Lindeman GJ, Visvader JE. Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland. BMC Dev Biol 8:94, 2008 MGC BIO MMD

Baum J, Chen L, Healer J, Lopaticki S, Boyle M, Triglia T, Ehlgen F, Ralph SA, Beeson JG, Cowman AF. Reticulocyte-binding protein homologue 5 - An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol 39:371-380, 2009 INF

Baum J, Papenfuss AT, Mair GR, Janse CJ, Vlachou D, Waters AP, Cowman AF, Crabb BS, de Koning-Ward TF. Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res 37:3788-3798, 2009 INF BIO

Bedoui S, Davey GM, Lew AM, Heath WR. Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process. Immunol Cell Biol 87:255-259, 2009 ATD IMM

Bedoui S, Prato S, Mintern J, Gebhardt T, Zhan Y, Lew AM, Heath WR, Villadangos JA, Segura E. Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses. J Immunol 182:4200-4207, 2009 IMM ATD

Bedoui S, Whitney PG, Waithman J, Eidsmo L, Wakim L, Caminschi I, Allan RS, Wojtasiak M, Shortman K, Carbone FR, Brooks AG, Heath WR. Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10:488-495, 2009 IMM

Bengtsson H, Ray A, Spellman P, Speed TP. A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods. Bioinformatics 25:861-867, 2009 BIO

Bengtsson H, Wirapati P, Speed TP. A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6. Bioinformatics Jun 17, 2009 (Epub ahead of print) BIO

Biankin AV, Kench JG, Colvin EK, Segara D, Scarlett CJ, Nguyen NQ, Chang DK, Morey AL, Lee CS, Pinese M, Kuo SC, Susanto JM, Cosman PH, Lindeman GJ, Visvader JE, Nguyen TV, Merrett ND, Warusavitarne J, Musgrove EA, Henshall SM, Sutherland RL. Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Gastroenterology Apr 16, 2009 (Epub ahead of print) MGC

Blekhman R, Oshlack A, Chabot AE, Smyth GK, Gilad Y. Gene regulation in primates evolves under tissue-specific selection pressures. PLoS Genet 4:e1000271, 2008 BIO

Blekhman R, Oshlack A, Gilad Y. Segmental duplications contribute to gene expression differences between humans and chimpanzees. Genetics 182:627-630, 2009 BIO

Boddey JA, Moritz RL, Simpson RJ, Cowman AF. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic 10:285-299, 2008 INF JPS

Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR, Lindeman GJ, Visvader JE. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 3:429-441, 2008 MGC

Boyle K, Zhang JG, Nicholson SE, Trounson E, Babon JJ, McManus EJ, Nicola NA, Robb L. Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation. Cell Signal 21:394-404, 2009 CHD SBD

Brady JL, Mannering SI, Kireta S, Coates PT, Proietto AI, Cowan PJ, D'Apice AJ, Lew AM. Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. Immunol Cell Biol 87:413-418, 2009 ATD IMM

Bryant PA, Smyth GK, Robins-Browne R, Curtis N. Detection of gene expression in an individual cell type within a cell mixture using microarray analysis. PLoS ONE 4:e4427, 2009 BIO

Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR. A novel family Of apicomplexan glideosome associated proteins With an inner-membrane anchoring role. J Biol Chem Jun 26, 2009 (Epub ahead of print) IMM BIO

Camarca A, Anderson RP, Mamone G, Fierro O, Facchiano A, Costantini S, Zanzi D, Sidney J, Auricchio S, Sette A, Troncone R, Gianfrani C. Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease. J Immunol 182:4158-4166, 2009 ATD

Caminschi I, Proietto AI, Ahmet F, Kitsoulis S, Shin Teh J, Lo JC, Rizzitelli A, Wu L, Vremec D, van Dommelen SL, Campbell IK, Maraskovsky E, Braley H, Davey GM, Mottram P, van de Velde N, Jensen K, Lew AM, Wright MD, Heath WR, Shortman K, Lahoud MH. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112:3264-3273, 2008 IMM ATD

Campbell IK, Kinkel SA, Drake SF, Nieuwenhuijze AV, Hubert FX, Tarlinton DM, Heath WR, Scott HS, Wicks IP. Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis. Arthritis Rheum 60:1683-1693, 2009 ATD MMD IMM

Cancer Genome Atlas Research Network, including Robinson M, Speed TP. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068, 2008 BIO

Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455:757-763, 2008 INF MMD

Carmichael CL, Majewski IJ, Alexander WS, Metcalf D, Hilton DJ, Hewitt CA, Scott HS. Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood 113:1929-1937, 2009 MMD CHD

Carrington EM, McKenzie MD, Jansen ES, Myers M, Fynch S, Koz C, Strasser A, Kay TW, Scott CL, Allison J. Islet beta cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes Jul 6, 2009 (Epub ahead of print) MGC

Chan AC, Serwecinska L, Cochrane A, Harrison LC, Godfrey DI, Berzins SP. Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family. Clin Exp Immunol 156:238-245, 2009 ATD

Chandran D, Tai YC, Hather G, Dewdney J, Denoux C, Burgess DG, Ausubel FM, Speed TP, Wildermuth MC. Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis. Plant Physiol 149:1435-1451, 2009 BIO

Chatfield SM, Wicks IP, Sturgess AD, Roberts LJ. Anti-citrullinated peptide antibody: death of the rheumatoid factor? Med J Aust 190:693-695, 2009 ATD

Cheng Y, Wakefield M, Siddle HV, Coggill PC, Herbert CA, Beck S, Belov K, Eldridge MDB. Isolation and characterization of 10 MHC Class I-associated microsatellite loci in tammar wallaby (Macropus eugenii). Mol Ecol Resour 9:346-349, 2009 BIO

Chevrier S, Genton C, Kallies A, Karnowski A, Otten LA, Malissen B, Malissen M, Botto M, Corcoran LM, Nutt SL, Acha-Orbea H. CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A 106:3895-3900, 2009 IMM

Chong LX, Ash MR, Maher MJ, Hinds MG, Xiao Z, Wedd AG. Unprecedented binding cooperativity between CuI and CuII in the copper resistance protein CopK from Cupriavidus metallidurans CH34: implications from structural studies by NMR spectroscopy and X-ray crystallography. J Am Chem Soc 131:3549-3564, 2009 SBD

Cole-Tobian JL, Michon P, Biasor M, Richards JS, Beeson JG, Mueller I, King CL. Strain-specific Duffy binding protein antibodies correlate with protection against infection with homologous compared to heterologous Plasmodium vivax strains in Papua New Guinean children. Infect Immun Jun 29, 2009 (Epub ahead of print) INF

Compton AG, Albrecht DE, Seto JT, Cooper ST, Ilkovski B, Jones KJ, Challis D, Mowat D, Ranscht B, Bahlo M, Froehner SC, North KN. Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. Am J Hum Genet 83:714-724, 2008 BIO

Couper JJ, Beresford S, Hirte C, Baghurst PA, Pollard A, Tait BD, Harrison LC, Colman PG. Weight gain in early life predicts risk of islet autoimmunity in children with a first degree relative with type 1 diabetes. Diabetes Care 32:94-99, 2008 ATD

Cragg MS, Jansen ES, Cook M, Harris C, Strasser A, Scott CL. Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J Clin Invest 118:3651-3659, 2008 MGC

Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A 105:15028-15033, 2008 CHD

D'Costa K, Emslie D, Metcalf D, Smyth GK, Karnowski A, Kallies A, Nutt SL, Corcoran LM. Blimp1 is limiting for transformation in a mouse plasmacytoma model. Blood 113:5911-5919, 2009 IMM CHD BIO

D'Ombrain MC, Robinson LJ, Stanisic DI, Taraika J, Bernard N, Michon P, Mueller I, Schofield L. Association of early interferon‐γ production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children. Clin Infect Dis 47:1380-1387, 2008 INF

Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG. Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol 380:958-971, 2008 SB

de Jong-Curtain TA, Parslow AC, Trotter AJ, Hall NE, Verkade H, Tabone T, Christie EL, Crowhurst MO, Layton JE, Shepherd IT, Nixon SJ, Parton RG, Zon LI, Stainier DY, Lieschke GJ, Heath JK. Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology 136:902-911, 2009 CHD

de Kauwe AL, Chen Z, Anderson RP, Keech CL, Price JD, Wijburg O, Jackson DC, Ladhams J, Allison J, McCluskey J. Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. J Immunol 182:7440-7450, 2009 ATD

de Koning-Ward TF, Gilson PR, Boddey JA, Rug M, Smith BJ, Papenfuss AT, Sanders PR, Lundie RJ, Maier AG, Cowman AF, Crabb BS. A newly discovered protein export machine in malaria parasites. Nature 459:945-949, 2009 INF SBD BIO

Deakin JE, Koina E, Waters PD, Doherty R, Patel VS, Delbridge ML, Dobson B, Fong J, Hu Y, van den Hurk C, Pask AJ, Shaw G, Smith C, Thompson K, Wakefield MJ, Yu H, Renfree MB, Graves JA. Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals. Chromosome Res 16:1159-1175, 2008 BIO

Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell 33:109-116, 2009 MGC

Dent AE, Bergmann-Leitner ES, Wilson DW, Tisch DJ, Kimmel R, Vulule J, Sumba PO, Beeson JG, Angov E, Moormann AM, Kazura JW. Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults. PLoS ONE 3:e3557, 2008 INF

Desimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol 72:578-589, 2009 INF

Dowling MR, Hodgkin PD. Modelling naive T-cell homeostasis: consequences of heritable cellular lifespan during ageing. Immunol Cell Biol Mar 17, 2009 (Epub ahead of print) IMM

Drechsler A, Miles AJ, Norton RS, Wallace BA, Separovic F. Effect of lipid on the conformation of the N-terminal region of equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study. Eur Biophys J Apr 3, 2009 (Epub ahead of print) SBD

Egan PJ, van Nieuwenhuijze A, Campbell IK, Wicks IP. Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis. Arthritis Rheum 58:3720-3729, 2008 ATD

Eidsmo L, Allan R, Caminschi I, van Rooijen N, Heath WR, Carbone FR. Differential migration of epidermal and dermal dendritic cells during skin infection. J Immunol 182:3165-3172, 2009 IMM

Ellett F, Kile BT, Lieschke GJ. The role of the ETS factor erg in zebrafish vasculogenesis. Mech Dev 126:220-229, 2009 CHD MMD

Ellis L, Bots M, Lindemann RK, Bolden JE, Newbold A, Cluse LA, Scott CL, Strasser A, Atadja P, Lowe SW, Johnstone RW. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood 114:380-383, 2009 MGC

Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, James WG, Metcalf D, Campbell IK, Wicks IP. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 112:5193-5201, 2008 ATD CHD

Feichtner S, Infuhr D, Achatz-Straussberger G, Schmid D, Karnowski A, Lamers M, Rhyner C, Crameri R, Achatz G. Targeting the extracellular membrane-proximal domain of membrane-bound IgE by passive immunization blocks IgE synthesis in vivo. J Immunol 180:5499-5505, 2008 IMM

Field KM, Jenkins MA, Friedlander ML, McKinley JM, Price MA, Weideman P, Keogh LA, McLachlan SA, Lindeman GJ, Hopper JL, Butow PN, Phillips KA. Predictors of the use of complementary and alternative medicine (CAM) by women at high risk for breast cancer. Eur J Cancer 45:551-560, 2009 MGC

Filipowicz M, Wang X, Yan M, Duong FH, Poli V, Hilton DJ, Zhang DE, Heim MH. Interferon alpha induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol Jun 29, 2009 (Epub ahead of print) MMD

Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A 105:18081-18087, 2008 MGC INF SBD

Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee WK, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A 106:5082-5087, 2009 SBD

Ge Y, Sealfon SC, Speed TP. Some step-down procedures controlling the false discovery rate under dependence. Stat Sinica 18:881-904, 2008 BIO

Ghosh AP, Walls KC, Klocke BJ, Toms R, Strasser A, Roth KA. The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis. J Neuropathol Exp Neurol 68:747-756, 2009 MGC

Gill J, Yogavel M, Kumar A, Belrhali H, Jain SK, Rug M, Brown M, Maier AG, Sharma A. Crystal structure of malaria parasite nucleosome assembly protein: Distinct modes of protein localization and histone recognition. J Biol Chem 284:10076-10087, 2009 INF

Gilson PR, Crabb BS. Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. Int J Parasitol 39:91-96, 2009 INF

Glaser S, Lubitz S, Loveland KL, Ohbo K, Robb L, Schwenk F, Seibler J, Roellig D, Kranz A, Anastassiadis K, Stewart AF. The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin 2:5, 2009 CHD

Gonez LJ, Naselli G, Banakh I, Niwa H, Harrison LC. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Mol Med 14:697-704, 2008 ATD

Greenbaum CJ, Mandrup-Poulsen T, McGee PF, Battelino T, Haastert B, Ludvigsson J, Pozzilli P, Lachin JM, Kolb H, Type 1 Diabetes Trial Net Research Group including Harrison LC, European C-Peptide Trial Study Group. Mixed-meal tolerance test versus glucagon stimulation test for the assessment of β-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 31:1966-1971, 2008 ATD

Han P, Zhang X, Norton RS, Feng ZP. Large-scale prediction of long disordered regions in proteins using random forests. BMC Bioinformatics 10:8, 2009 SBD

Harris KS, Casey JL, Coley AM, Karas JA, Sabo JK, Tan YY, Dolezal O, Norton RS, Hughes AB, Scanlon D, Foley M. Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning. J Biol Chem 284:9361-9371, 2009 SBD

Hart E, Yang J, Tauschek M, Kelly M, Wakefield MJ, Frankel G, Hartland EL, Robins-Browne RM. RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium. Infect Immun 76:5247-5256, 2008 BIO

Hawkins ED, Markham JF, McGuiness LP, Hodgkin PD. A single cell pedigree analysis of alternative stochastic lymphocyte fates. Proc Natl Acad Sci U S A IMM

Hilton DJ, Kile BT, Alexander WS. Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood 113:5599-5604, 2009 MMD CHD

Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S. A tumor suppressor function for caspase-2. Proc Natl Acad Sci U S A 106:5336-5341, 2009 MGC

Hodder AN, Maier AG, Rug M, Brown M, Hommel M, Pantic I, Puig-de-Morales-Marinkovic M, Smith B, Triglia T, Beeson J, Cowman AF. Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum. Mol Microbiol 71:48-65, 2009 INF SBD

Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrob Agents Chemother 53:2824-2833, 2009 SBD

Howlett M, Giraud AS, Lescesen H, Jackson CB, Kalantzis A, Van Driel IR, Robb L, Van der Hoek M, Ernst M, Minamoto T, Boussioutas A, Oshima H, Oshima M, Judd LM. The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology 136:967-977, 2009 CHD

Hu Y, Smyth GK. ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods Jun 27, 2009 (Epub ahead of print) BIO

Huang Z, Kawase-Koga Y, Zhang S, Visvader J, Toth M, Walsh CA, Sun T. Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control. Dev Biol 327:132-142, 2009 MGC

Hubert FX, Kinkel SA, Crewther PE, Cannon PZ, Webster KE, Link M, Uibo R, O'Bryan MK, Meager A, Forehan SP, Smyth GK, Mittaz L, Antonarakis SE, Peterson P, Heath WR, Scott HS. Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J Immunol 182:3902-3918, 2009 MMD SBD INF BIO

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7. Int Immunol 21:715-725, 2009 MGC

Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 16:555-563, 2009 MGC

Jackaman C, Cornwall S, Lew AM, Zhan Y, Robinson BW, Nelson DJ. Local effector failure in mesothelioma is not mediated by CD4+CD25+T-regulator cells. Eur Respir J 34:162-175, 2009 ATD

Jackaman C, Lew AM, Zhan Y, Allan JE, Koloska B, Graham PT, Robinson BW, Nelson DJ. Deliberately provoking local inflammation drives tumors to become their own protective vaccine site. Int Immunol 20:1467-1479, 2008 ATD

Johnson S, Zhan Y, Sutherland RM, Mount AM, Bedoui S, Brady JL, Carrington EM, Brown LE, Belz GT, Heath WR, Lew AM. Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells. Immunity 30:218-227, 2009 ATD IMM

Jost PJ, S. G, Gray D, McKenzie MD, Nachbur U, Huang DCS, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP acts as a switch beween type I and type II Fas-induced apoptosis signalling. Nature (in press) MGC

Kadekoppala M, O'Donnell RA, Grainger M, Crabb BS, Holder AA. Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairs parasite invasion of erythrocytes. Eukaryot Cell 7:2123-2132, 2008 INF

Karnowski A, Cao C, Matthias G, Carotta S, Corcoran LM, Martensson IL, Skok JA, Matthias P. Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. PLoS ONE 3:e3568, 2008 IMM

Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A. Fatal hepatitis mediated by tumor necrosis factor TNFα requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity 30:56-66, 2009 MGC IMM

Kauppi M, Murphy JM, de Graaf CA, Hyland CD, Greig KT, Metcalf D, Hilton AA, Nicola NA, Kile BT, Hilton DJ, Alexander WS. Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 112:3148-3153, 2008 CHD MMD

Kedzierski L, Curtis JM, Doherty PC, Handman E, Kedzierska K. Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites. Eur J Immunol 38:3090-3100, 2008 INF

Kedzierski L, Curtis JM, Kedzierska K. Early CD44hiCD4+ and CD44hiCD8+ T cell numbers and the absence of mannose-rich glycoconjugates determine the protective outcome of anti-leishmanial immunity. Parasitology 136:833-840, 2009 INF

Khoo KK, Feng ZP, Smith BJ, Zhang MM, Yoshikami D, Olivera BM, Bulaj G, Norton RS. Structure of the analgesic μ-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry 58:1210-1219, 2009 SBD

Kuang Z, Yao S, McNeil KA, Forbes BE, Wallace JC, Norton RS. Insulin-like growth factor-I (IGF-I): solution properties and NMR chemical shift assignments near physiological pH. Growth Horm IGF Res 19:226-231, 2009 SBD

Kuang Z, Yao S, Xu Y, Lewis RS, Low A, Masters SL, Willson TA, Kolesnik TB, Nicholson SE, Garrett TJ, Norton RS. SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding. J Mol Biol 386:662-674, 2009 SBD CHD MMD

Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID, Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I. The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol 182:7587-7594, 2009 IMM ATD

Lawrentschuk N, Lee FT, Jones G, Rigopoulos A, Mountain A, O'Keefe G, Papenfuss AT, Bolton DM, Davis ID, Scott AM. Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and 124I-cG250 PET/CT. Urol Oncol Jun 11, 2009 (Epub ahead of print) BIO

Lay MD, Zhang L, Ribeiro RM, Mueller SN, Belz GT, Davenport MP. Kinetics of major histocompatibility class I antigen presentation in acute infection. J Immunol 182:902-911, 2009 IMM

Lee C, Kolesnik TB, Caminschi I, Chakravorty A, Carter W, Alexander WS, Jones J, Anderson GP, Nicholson SE. Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response. Clin Exp Allergy 39:897-907, 2009 CHD IMM

Lee EF, Sadowsky JD, Smith BJ, Czabotar PE, Peterson-Kaufman KJ, Colman PM, Gellman SH, Fairlie WD. High-resolution structural characterization of a helical α/β-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl 48:4318-4322, 2009 SBD

Lee HY, Hawkins E, Zand MS, Mosmann T, Wu H, Hodgkin PD, Perelson AS. Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models. Bull Math Biol Apr 21, 2009 (Epub ahead of print) IMM

Loi S, Sotiriou C, Haibe-Kains B, Lallemand F, Conus NM, Piccart MJ, Speed TP, McArthur GA. Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. BMC Med Genomics 2:37, 2009 BIO

Londrigan SL, Brady JL, Sutherland RM, Cowan PJ, d'Apice AJ, Hawthorne WJ, O'Connell PJ, Lew AM. Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation 16:45-46, 2009 ATD

Lundie RJ, de Koning-Ward TF, Davey GM, Nie CQ, Hansen DS, Lau LS, Mintern JD, Belz GT, Schofield L, Carbone FR, Villadangos JA, Crabb BS, Heath WR. Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8α+ dendritic cells. Proc Natl Acad Sci U S A 105:14509-14514, 2008 IMM INF

MacRaild CA, Illesinghe J, van Lierop BJ, Townsend AL, Chebib M, Livett BG, Robinson AJ, Norton RS. Structure and activity of (2,8)-dicarba-(3,12)-cystino α-ImI, an α-conotoxin containing a nonreducible cystine analogue. J Med Chem 52:755-762, 2009 SBD

Maier AG, Baum J, Smith B, Conway DJ, Cowman AF. Polymorphisms in the erythrocyte binding antigens-140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum. Infect Immun 77:1689-1699, 2009 INF SBD

Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC. The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clin Exp Immunol 156:226-231, 2009 ATD

Manzur M, Fleming P, Huang DCS, Degli-Esposti MA, Andoniou CE. Virally mediated inhibition of Bax in leukocytes promotes dissemination of murine cytomegalovirus. Cell Death Differ 16:312-320, 2009 MGC

Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci U S A 105:17961-17966, 2008 MGC CHD

Mathias RA, Wang B, Ji H, Kapp EA, Moritz RL, Zhu HJ, Simpson RJ. Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition. J Proteome Res 8:2827-2837, 2009 JPS

McCallum FJ, Persson KE, Mugyenyi CK, Fowkes FJ, Simpson JA, Richards JS, Williams TN, Marsh K, Beeson JG. Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum. PLoS ONE 3:e3571, 2008 INF

McCarthy DJ, Smyth GK. Testing significance relative to a fold-change threshold is a TREAT. Bioinformatics 25:765-771, 2009 BIO

McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, Corbin JE, Alexander WS, Foote SJ. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 323:797-800, 2009 MMD BIO CHD

Menkhorst E, Salamonsen L, Robb L, Dimitriadis E. IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice. Biol Reprod 80:920-927, 2009 CHD

Menting JG, Ward CW, Margetts MB, Lawrence MC. A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor α-chain C-terminal peptide and the site 1 insulin mimetic peptides. Biochemistry 48:5492-5500, 2009 SBD

Merino D, Giam M, Hughes PD, Siggs OM, Heger K, O'Reilly LA, Adams JM, Strasser A, Lee EF, Fairlie WD, Bouillet P. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like pro-survival proteins. J Cell Biol (in press) MGC SBD

Metcalf D, Greig KT, de Graaf CA, Loughran SJ, Alexander WS, Kauppi M, Hyland CD, Di Rago L, Mifsud S. Two distinct types of murine blast colony-forming cells are multipotential hematopoietic precursors. Proc Natl Acad Sci U S A 105:18501-18506, 2008 CHD MMD IMM

Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL. Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ 16:684-696, 2009 MGC BIO

Michaud J, Simpson KM, Escher R, Buchet-Poyau K, Beissbarth T, Carmichael C, Ritchie ME, Schutz F, Cannon P, Liu M, Shen X, Ito Y, Raskind WH, Horwitz MS, Osato M, Turner DR, Speed TP, Kavallaris M, Smyth GK, Scott HS. Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics 9:363, 2008 MMD INF BIO

Mintern JD, Bedoui S, Davey GM, Moffat JM, Doherty PC, Turner SJ. Transience of MHC Class I-restricted antigen presentation after influenza A virus infection. Proc Natl Acad Sci U S A 106:6724-6729, 2009 IMM

Mukherjee S, Pelech S, Neve RM, Kuo WL, Ziyad S, Spellman PT, Gray JW, Speed TP. Sparse combinatorial inference with an application in cancer biology. Bioinformatics 25:265-271, 2009 BIO

Mukherjee S, Speed TP. Network inference using informative priors. Proc Natl Acad Sci U S A 105:14313-14318, 2008 BIO

Murhandarwati EE, Black CG, Wang L, Weisman S, Koning-Ward TF, Baird JK, Tjitra E, Richie TL, Crabb BS, Coppel RL. Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections. J Infect Dis 198:1212-1218, 2008 INF

Nie CQ, Bernard NJ, Norman MU, Amante FH, Lundie RJ, Crabb BS, Heath WR, Engwerda CR, Hickey MJ, Schofield L, Hansen DS. IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog 5:e1000369, 2009 INF

O'Reilly LA, Kruse EA, Puthalakath H, Kelly PN, Kaufmann T, Huang DC, Strasser A. MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. J Immunol 183:261-269, 2009 MGC

Oshlack A, Wakefield MJ. Transcript length bias in RNA-seq data confounds systems biology. Biol Direct 4:14, 2009 BIO

Pain A, Bohme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG, Berriman M. The genome of the simian and human malaria parasite Plasmodium knowlesi. Nature 455:799-803, 2008 MMD INF

Parish IA, Rao S, Smyth GK, Juelich T, Denyer GS, Davey GM, Strasser A, Heath WR. The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood 113:4575-4585, 2009 BIO MGC

Parish IA, Waithman J, Davey GM, Belz GT, Mintern JD, Kurts C, Sutherland RM, Carbone FR, Heath WR. Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance. Proc Natl Acad Sci U S A 106:3901-3906, 2009 IMM ATD

Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ. miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood 113:1794-1804, 2009 CHD

Pask AJ, Papenfuss AT, Ager EI, McColl KA, Speed TP, Renfree MB. Analysis of the platypus genome suggests a transposon origin for mammalian imprinting. Genome Biol 10:R1, 2009 BIO

Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol 75:762-773, 2009 SBD

Phuc BQ, Caruana SR, Cowman AF, Biggs BA, Thanh NV, Tien NT, Thuan le K. Prevalence of polymorphisms in dhfr, dhps, pfmdr1 and pfcrt genes of Plasmodium falciparum isolates in Quang Tri Province, Vietnam. Southeast Asian J Trop Med Public Health 39:959-962, 2008 INF

Pietersz GA, Mottram PL, van de Velde NC, Sardjono CT, Esparon S, Ramsland PA, Moloney G, Baell JB, McCarthy TD, Matthews BR, Powell MS, Hogarth PM. Inhibition of destructive autoimmune arthritis in FcgγRIIa transgenic mice by small chemical entities. Immunol Cell Biol 87:3-12, 2009 SBD

Powell KL, Cain SM, Ng C, Sirdesai S, David LS, Kyi M, Garcia E, Tyson JR, Reid CA, Bahlo M, Foote SJ, Snutch TP, O'Brien TJ. A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J Neurosci 29:371-380, 2009 BIO

Prele CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, Hart PH. SOCS1 regulates the IFN but not NFκB pathway in TLR-stimulated human monocytes and macrophages. J Immunol 181:8018-8026, 2008 CHD

Proietto AI, Lahoud MH, Wu L. Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 86:700-708, 2008 IMM

Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K, Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci U S A 105:19869-19874, 2008 IMM

Rank G, Sutton R, Marshall V, Lundie RJ, Caddy J, Romeo T, Fernandez K, McCormack MP, Cooke BM, Foote SJ, Crabb BS, Curtis DJ, Hilton DJ, Kile BT, Jane SM. Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood 113:3352-3362, 2009 MMD

Richard D, Kats LM, Langer C, Black CG, Mitri K, Boddey JA, Cowman AF, Coppel RL. Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum. PLoS Pathog 5:e1000328, 2009 INF

Robinson LJ, D'Ombrain MC, Stanisic DI, Taraika J, Bernard N, Richards JS, Beeson JG, Tavul L, Michon P, Mueller I, Schofield L. Cellular TNF, IFN-γ and IL-6 responses: correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea. Infect Immun 77:3033-3043, 2009 INF IMM

Robinson MD, Speed TP. Differential splicing using whole-transcript microarrays. BMC Bioinformatics 10:156, 2009 BIO

Rubio JP, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C, Bahlo M, Perera D, Johnson LJ, Tait BD, Varney MD, Speed TP, Taylor BV, Foote SJ, Butzkueven H, Kilpatrick TJ. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 9:624-630, 2008 BIO

Schlub TE, Venturi V, Kedzierska K, Wellard C, Doherty PC, Turner SJ, Ribeiro RM, Hodgkin PD, Davenport MP. Division-linked differentiation can account for CD8+ T-cell phenotype in vivo. Eur J Immunol 39:67-77, 2009 IMM

Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood Apr 22, 2009 (Epub ahead of print) MMD MGC CHD

Sewak S, Kosmider S, Ganju V, Woollett A, Yeow E, Le B, Henry M, Debrincat M, Bell R. A Phase II study of Paclitaxel and Vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: Double Tubulin Targeting. Intern Med J May 21, 2009 (Epub ahead of print) MMD

Shackleton M, O'Reilly LA, Sutherland KD, Bath ML, Ellis S, Strasser A, Visvader JE, Lindeman GJ. Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium. Dev Dyn 238:1010-1016, 2009 MGC

Shearer AE, Hildebrand MS, Bromhead CJ, Kahrizi K, Webster JA, Azadeh B, Kimberling WJ, Anousheh A, Nazeri A, Stephan D, Najmabadi H, Smith RJ, Bahlo M. A novel splice site mutation in the RDX gene causes DFNB24 hearing loss in an Iranian family. Am J Med Genet A 149A:555-558, 2009 BIO

Shearer AE, Hildebrand MS, Webster JA, Kahrizi K, Meyer NC, Jalalvand K, Arzhanginy S, Kimberling WJ, Stephan D, Bahlo M, Smith RJ, Najmabadi H. Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing loss. Laryngoscope 119:727-733, 2009 BIO

Silver JD, Ritchie ME, Smyth GK. Microarray background correction: maximum likelihood estimation for the normal-exponential convolution. Biostatistics 10:352-363, 2009 BIO

Smyth GK, Verbyla AP. Leverage adjustments for dispersion modelling in generalized nonlinear models. Aust N Z J Stat (in press) BIO

Smyth I, Hacking DF, Hilton AA, Mukhamedova N, Meikle PJ, Ellis S, Slattery K, Collinge JE, de Graaf CA, Bahlo M, Sviridov D, Kile BT, Hilton DJ. A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet 4:e1000192, 2008 MMD BIO

Stanisic DI, Richards JS, McCallum FJ, Michon P, King CL, Schoepflin S, Gilson PR, Murphy VJ, Anders RF, Mueller I, Beeson JG. Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness. Infect Immun 77:1165-1174, 2009 INF

Stehling-Sun S, Dade J, Nutt SL, Dekoter RP, Camargo FD. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol 10:289-296, 2009 IMM

Storey E, Bahlo M, Fahey MC, Sisson O, Lueck CJ, Gardner RM. A new dominantly-inherited pure cerebellar ataxia, SCA 30. J Neurol Neurosurg Psychiatry 80:408-411, 2009 BIO

Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese S, Ikeda H, Haynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K. Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. Proc Natl Acad Sci U S A 105:10895-10900, 2008 IMM

Tew DJ, Bottomley SP, Smith DP, Ciccotosto GD, Babon J, Hinds MG, Masters CL, Cappai R, Barnham KJ. Stabilization of neurotoxic soluble β-sheet-rich conformations of the Alzheimer's disease amyloid-β peptide. Biophys J 94:2752-2766, 2008 SBD

Tham WH, Wilson DW, Reiling L, Chen L, Beeson JG, Cowman AF. Antibodies to reticulocyte binding like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes. Infect Immun 77:2427-2435, 2009 INF

Theodorou E, Dalembert G, Heffelfinger C, White E, Weissman S, Corcoran L, Snyder M. A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation. Genes Dev 23:575-588, 2009 IMM

Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol 7:e84, 2009 INF BIO

Turner ML, Hawkins ED, Hodgkin PD. Quantitative regulation of B cell division destiny by signal strength. J Immunol 181:374-382, 2008 IMM

Vaillant F, Asselin-Labat ML, Shackleton M, Forrest NC, Lindeman GJ, Visvader JE. The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 68:7711-7717, 2008 MGC

Van Buskirk KM, O'Neill MT, De La Vegas P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB, Jr., Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG, Jr., Murdock BA, Mkolajczak SA, Aly ASI, Cowman AF, Kappe SHI. Pre-erythrocytic live-attentuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A (in press) INF

Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol 11:506-520, 2009 INF

Verhagen AM, Wallace ME, Goradia A, Jones SA, Croom HA, Metcalf D, Collinge JE, Maxwell MJ, Hibbs ML, Alexander WS, Hilton DJ, Kile BT, Starr R. A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol 182:2020-2029, 2009 CHD MMD

White PJ, Anastasopoulos F, Church JE, Kuo CY, Boyd BJ, Hickey PL, Tu LS, Burns P, Lew AM, Heath WR, Davey GM, Pouton CW. Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants. Vaccine 26:6824-6831, 2008 ATD IMM

Whiteford N, Skelly T, Curtis C, Ritchie ME, Lohr A, Zaranek AW, Abnizova I, Brown C. Swift: Primary Data Analysis for the Illumina Solexa Sequencing Platform. Bioinformatics Jun 23, 2009 (Epub ahead of print) BIO

Whittington CM, Koh JM, Warren WC, Papenfuss AT, Torres AM, Kuchel PW, Belov K. Understanding and utilising mammalian venom via a platypus venom transcriptome. J Proteomics 72:155-164, 2009 BIO

Whittington CM, Papenfuss AT, Kuchel PW, Belov K. Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected. Toxicon 52:559-565, 2008 BIO

Wiede F, Roomberg A, Cretney E, Lechner A, Fromm P, Wren L, Smyth MJ, Korner H. Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice. J Leukoc Biol 85:108-116, 2009 IMM

Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS. Structure, dynamics, and selectivity of the sodium channel blocker μ-conotoxin SIIIA. Biochemistry 47:10940-10949, 2008 SBD

Young LJ, Wilson NS, Schnorrer P, Proietto A, ten Broeke T, Matsuki Y, Mount AM, Belz GT, O'Keeffe M, Ohmura-Hoshino M, Ishido S, Stoorvogel W, Heath WR, Shortman K, Villadangos JA. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells. Nat Immunol 9:1244-1252, 2008 IMM

Zhan Y, Davey GM, Graham KL, Kiu H, Dudek NL, Kay TW, Lew AM. SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus. Immunol Cell Biol Apr 21, 2009 (Epub ahead of print) ATD CHD

Zhan Y, Gerondakis S, Coghill E, Bourges D, Xu Y, Brady JL, Lew AM. Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-κB and NFAT. J Immunol 181:5405-5413, 2008 ATD

Zhao Q, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol 16:304-311, 2009 JPS

Zheng Y, Chaudhry A, Kas A, Deroos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458:351-356, 2009 IMM

Zhu Y, Davis A, Smith B, Curtis J, Handman E. Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence. Int J Parasitol 39:713-723, 2009 INF SBD

Zikova A, Panigrahi AK, Uboldi AD, Dalley RA, Handman E, Stuart K. Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex. Eukaryot Cell 7:1994-2003, 2008 INF

Reviews and Books

Adams JM, Kelly PN, Dakic A, Carotta S, Nutt SL, Strasser A. Role of "cancer stem cells" and cell survival in tumor development and maintenance. Cold Spring Harb Symp Quant Biol 73:451-459, 2008 MGC IMM

Anderson RP. Coeliac disease: current approach and future prospects. Intern Med J 38:790-799, 2008 ATD

Asselin-Labat ML, Vaillant F, Shackleton M, Bouras T, Lindeman GJ, Visvader JE. Delineating the epithelial hierarchy in the mouse mammary gland. Cold Spring Harb Symp Quant Biol 73:469-478, 2008 MGC

Baum J, Gilberger TW, Frischknecht F, Meissner M. Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends Parasitol 24:557-563, 2008 INF

Beeson JG, Osier FH, Engwerda CR. Recent insights into humoral and cellular immune responses against malaria. Trends Parasitol 24:578-584, 2008 INF

Belz GT. Getting together: dendritic cells, T cells, collaboration and fates. Immunol Cell Biol 86:310-311, 2008 IMM

Belz GT. DC migration: hard-wired for T cell activation. Immunity 29:388-390, 2008 IMM

Belz GT. Portrait of a leading vaccinologist: the tapestry of the immune response for protective immunity. Hum Vaccin 5:50-52, 2009 IMM

Belz GT. Life in the balance: killer T-cell self-control fends off lethal influenza? Immunol Cell Biol 87:364-365, 2009 IMM

Belz GT, De Groot A. The Sir Mark Oliphant Conferences: International frontiers of science and technology. Hum Vaccin 4:260-261, 2008 IMM

Belz GT, Mount AM, Masson F. Dendritic cells in viral infection. In: Lombardi G, Vasquez Y. ed. Dendritic cells. Berlin: Springer; 51-77, 2009 IMM

Billas IML, Browning C, Lawrence MC, Graham LD, Moras D, Hill RJ. The structure and function of ecdysone receptors. In: Smagghe G. ed. Ecdysone: structures and functions. Dordrecht: Springer; 335-360, 2009 SBD

Bouillet P, O'Reilly LA. CD95, BIM and T cell homeostasis. Nat Rev Immunol 9:514-519, 2009 MGC

Caminschi I, Lahoud MH, Shortman K. Enhancing immune responses by targeting antigen to DC. Eur J Immunol 39:931-938, 2009 IMM

Colman PG, Harrison LC. Prevention of type 1 diabetes. Diabetes Management J (in press) ATD

Colman PM. New antivirals and drug resistance. Annu Rev Biochem 78:95-118, 2009 SBD

Cragg MS, Harris C, Strasser A, Scott CL. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 9:321-326, 2009 MGC

Czabotar PE, Colman PM, Huang DC. Bax activation by Bim? Cell Death Differ Jun 26, 2009 (Epub ahead of print) SBD MGC

Davenport MP, Belz GT, Ribeiro RM. The race between infection and immunity: how do pathogens set the pace? Trends Immunol 30:61-66, 2009 IMM

Dowling MR, Hodgkin PD. Why does the thymus involute? a selection-based hypothesis. Trends Immunol 30:295-300, 2009 IMM

Giam M, Huang DCS, Bouillet P. BH3-only proteins and their roles in programmed cell death. Oncogene (in press) MGC

Greig KT, Carotta S, Nutt SL. Critical roles for c-Myb in hematopoietic progenitor cells. Semin Immunol 20:247-256, 2008 IMM

Hacking DF. 'Knock, and it shall be opened': knocking out and knocking in to reveal mechanisms of disease and novel therapies. Early Hum Dev 84:821-827, 2008 MMD

Haines ML, Anderson RP, Gibson PR. Systematic review: The evidence base for long-term management of coeliac disease. Aliment Pharmacol Ther 28:1042-1066, 2008 ATD

Happo L, Strasser A, Scott CL. BH3-only proteins. In: ed. Encyclopedia of Life Sciences. Hoboken, NJ: John Wiley & Sons (in press) MGC

Harrison LC. Vaccination for autoimmune and other chronic inflammatory disorders. In: Levine MM. ed. New generation vaccines 4th ed. New York, NY: Informa Healthcare (in press) ATD

Harrison LC. Contribution of genetic factors to type 1 diabetes has changed but not decreased over the last decades. Nat Rev Endocrinol (in press) ATD

Hogan BM, Verkade H, Lieschke GJ, Heath JK. Manipulation of gene expression during zebrafish embryonic development using transient approaches. Methods Mol Biol 469:273-300, 2008 CHD

Honeyman MC, Harrison LC. Congenital rubella, diabetes and HLA. Diabetologia 52:371-372; author reply 373, 2009 ATD

Honeyman MC, Harrison LC. The hygiene hypothesis and Type 1 diabetes. In: Rook GAW. ed. The Hygiene hypothesis and darwinian medicine. Basel: Birkhäuser (in press) ATD

Huang X, Shen N, Bao C, Gu Y, Wu L, Chen S. Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells. Arthritis Res Ther 10:R91, 2008 IMM

Josefsson EC, Kile BT. Cell death in the hematopoietic system. In: Xiao-Ming Y, Zheng D. ed. Essentials of apoptosis: a guide for basic and clinical research. 2nd ed. New York, NY: Humana Press; 443-460, 2009 MMD

Kedzierski L, Sakthianandeswaren A, Curtis JM, Andrews PC, Junk PC, Kedzierska K. Leishmaniasis: current treatment and prospects for new drugs and vaccines. Curr Med Chem 16:599-614, 2009 INF

Khaw SL, Huang DC, Roberts AW. BH3-mimetics--the solution to chemoresistance? Leuk Lymphoma 50:1069-1072, 2009 MGC CHD

Layton JE. Undertaking a successful gynogenetic haploid screen in zebrafish. Methods Mol Biol 546:31-44, 2009 CHD

Lee EF, Fairlie WD. Current controversies in Bcl-2-regulated apoptosis. In: Malloy AH, Carson EC. ed. Oncogene proteins: new research. New York: Nova Science Publishers; 217-231, 2008 SBD

Lessene G, Czabotar PE, Colman PM. BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov 7:989-1000, 2008 SBD

Lieschke GJ, Oates AC, Kawakami K. ed. Zebrafish methods and protocols. Dordrecht: Springer; 2009 CHD

Lieschke GJ, Trede N. Fish immunology. Curr Biol (in press) CHD

Maier AG, Cooke BM, Cowman AF, Tilley L. Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol 7:341-354, 2009 INF

Mathias RA, Simpson RJ. Towards understanding epithelial-mesenchymal transition: A proteomics perspective. Biochim Biophys Acta May 9, 2009 (Epub ahead of print) JPS

Merino D, Bouillet P. The Bcl-2 family in autoimmune and degenerative disorders. Apoptosis 14:570-583, 2009 MGC

Miller J. Response to Cohn's views. Immunol Cell Biol 87:120-121, 2009 IMM

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