Professor David Vaux's research into cell development and apoptosis
will take him to La Trobe University as a Federation Fellow.
Reflecting on his work, Professor Vaux comments, “Apoptosis is the normal and healthy process
by which most animal cells self-destruct. Apoptosis of the wrong cells, or the failure of faulty
or worn out cells to die when they should, has been observed in almost every disease.
“The health of a cell depends on its ability to control the intracellular environment. Study of
the Inhibitor of Apoptosis protein family has led to the discovery of a mechanism that controls
protein abundance within cells. Analysis of the mechanisms of apoptosis and protein homeostasis
will increase our understanding of these fundamental biological processes, providing novel
avenues for the treatment of heart attacks and diseases such as cancer.
“Understanding the molecular mechanisms of cell death is the first step towards developing drugs
that can cause cancer cells to kill themselves or prevent cells from dying when they should not.”
Professor Vaux is currently Senior Principal Research Fellow in WEHI’s Molecular
Genetics of Cancer Division, a Scholar of the Leukemia Society of America, a Fellow of the Australian
Academy of Science and a winner of the Victoria Prize, the Gottschalk Medal of the Australian Academy
of Science and the Glaxo Wellcome Australia medal.
WEHI Director, Professor Suzanne Cory, commented, “David is quite obviously a
scientist of great talent and creativity. His contributions to WEHI and the broader scientific
world have been remarkable. I’m sure that his achievements will continue to flourish in his
new environment at La Trobe University.”