Which pro-apoptotic BH3-only Bcl-2 family members are critical for anti-cancer therapy induced tumou
Using our panel of gene-targeted mice and transgenic mouse models of tumour development or panels of human tumour-derived cell lines and RNAi interference, we are investigating which pro-apoptotic BH3-only Bcl-2 family members are critical for the tumour cell killing effects of which anti-cancer therapeutics. Results from these studies are expected to provide valuable information for basic research and will also assist translational and clinical research.