The SOCS Box; A link between generic and substrate-specific components of E3 ubiquitin ligases
The eight SOCS family members
In addition to the canonical SOCS proteins that contain a central SH2 domain, we found several large and poorly characterized protein families that contain a C-terminal SOCS box and a variety of other protein-protein interaction domains including SPRY domains, WD40 repeats and ankyrin repeats. We hypothesize that each of these SOCS box containing proteins targets a specific protein for polyubiquitylation and degradation and are taking a variety of proteomic and genetic approaches to identify these substrates.
Interactions of LIF