The Walter and Eliza Hall Institute of Medical Research

Spatiotemporal dynamics of host cell invasion

We are probing how signal transduction events occur in a spatiotemporal manner using high-resolution imaging. By accessing the Walter and Eliza Hall Institute's high-end imaging workstations, in combination with the latest calcium and phosphoinositide biosensors, we will be able to reconstruct the steps that lead to invasion and how this occurs in space and time.

Movie A

Movie B

Conditional Toxoplasma invasion and egress mutant. A. A vacuole full of Toxoplasma parasites egressing (bursting out) from a host cell under permissive conditions. B. Under non-permissive conditions Toxoplasma parasites cannot exit host cells due to the key gene being turned off.