Metabolic flux analysis
Cells process chemicals: for example, they process of glucose to produce energy. Nature allows cells many potential pathways for this processing. Besides business-as-usual, a cell may sequester chemicals for later use, or have to switch to a less refined nutrient source. The flux in a metabolic pathway is a measure of how many molecules pass along it in a given time and can be inferred from a labelling experiment using enrichment estimates for end-point and intermediate metabolites. Our goal is to understand active pathways in pathogens which will allow drugs to be designed to treat diseases.