Investigations into the mechanisms that control programmed cell death during development of the mous
Using our panel of gene-targeted mice, we are investigating the roles of pro- as well as anti-apoptotic Bcl-2 family members in mouse development. We are particularly interested in identifying the mechanisms that govern the deletion of potentially dangerous lymphocytes and myeloid cells during their development and during the shut-down of immune responses. Results from these studies are expected to provide valuable information for basic research and will assist translational and clinical research by identifying potential therapeutic targets for autoimmune or inflammatory disorders.