Human epidemiological and human descriptive studies of tuberculosis and HIV infection
An important aspect of our work is discovery of novel therapeutic interventions that promote immune mediated control of chronic overwhelming infections. The ability to test these experimental therapies in pre-clinical models is a prerequisite to clinical translation.
The transition from basic science discoveries to clinical trials underpins our work but it is equally important to examine human epidemiological data and human correlates of disease that provide profound insights into pathogenesis and drive further basic science research.
To this end we are establishing collaborative field studies in Papua New Guinea and Uganda that will allow us to define population and host variables that impact on infectious disease outcomes in Mycobacterium tuberculosis and HIV infection. This will allow us to generate new hypotheses that can be tested in our basic science and pre-clinical models.