Dendritic cell subsets
Dendritic cell subsets direct the fate of T cell differentiation
Dendritic cells are critical to initiate the process of T cell activation, proliferation and differentiation. They are a heterogeneous population of cells and each of these populations seems to play a key role in the delivery of antigen to T cells and in defining the differentiation program of discrete subsets of T cells.
Dendritic cell subsets ferry viral antigenic cargo from the periphery to the lymph node to activate T cells
Transcriptional regulation of effector and memory T cell development
Once activated naïve CD8 T cells undergo differentiation into effector cytotoxic T cells and memory T cells. This differentiation process is regulated by transcription factors that determine whether a T cell will ultimately become a protective memory T cell.