The Walter and Eliza Hall Institute of Medical Research

Professor Suzanne Cory

Details

Email: .(JavaScript must be enabled to view this email address)
Division: Molecular Genetics of Cancer

Research Overview

Our laboratory uses genetically modified mice to clarify the role of different oncogenic mutations in the development of leukemia and lymphoma and responses to chemotherapy.

Research Projects

Myc

Bcl-2 family

Polycomb genes

Major Publications

1. Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW.
   In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas.
   Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17961-6 PMID: 19004807 [PubMed - indexed for MEDLINE]
2. Adams JM, Cory S.
   Bcl-2-regulated apoptosis: mechanism and therapeutic potential.
   Current Opinion in Immunology. 2007 Oct;19(5):488-96 PMID: 17629468 [PubMed - indexed for MEDLINE]
3. Adams JM, Cory S.
   The Bcl-2 Apoptotic switch in cancer development and therapy.
   Oncogene. 2007 Feb 26;26(9):1324-37 PMID: 17322918 [PubMed - indexed for MEDLINE]
4. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC.
   The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
   Cancer Cell. 2006 Nov;10(5):389-99 PMID: 17097561 [PubMed - indexed for MEDLINE]
5. Smith DP, Bath ML, Metcalf D, Harris AW, Cory S.
   MYC levels govern hematopoietic tumor type and latency in transgenic mice.
   Blood. 2006 Jul 15;108(2):653-61 PMID: 16537801 [PubMed - indexed for MEDLINE]
6. Cory S, Adams JM.
   Killing cancer cells by flipping the Bcl-2/Bax switch.
   Cancer Cell. 2005 Jul;8(1):5-6 PMID: 16023593 [PubMed - indexed for MEDLINE]
7. Smith DP, Bath ML, Harris AW, Cory S.
   T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC.
   Oncogene. 2005 May 19;24(22):3544-53 PMID: 15688022 [PubMed - indexed for MEDLINE]
8. Egle A, Harris AW, Bouillet P, Cory S.
   Bim is a suppressor of Myc-induced mouse B cell leukemia.
   Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6164-9 PMID: 15079075 [PubMed - indexed for MEDLINE]
9. Egle A, Harris AW, Bath ML, O'Reilly L, Cory S.
   VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia.
   Blood. 2004 Mar 15;103(6):2276-83 PMID: 14630790 [PubMed - indexed for MEDLINE]
10. Cory S, Huang DC, Adams JM.
    The Bcl-2 family: roles in cell survival and oncogenesis.
    Oncogene. 2003 Nov 24;22(53):8590-607 PMID: 14634621 [PubMed - indexed for MEDLINE]

Click here to view more PubMed publications

Current Laboratory Members

Faculty Fellow: Suzanne Cory AC MSc Melb PhD Cantab Hon DSc Syd Hon DSc Oxon FAA FRS

Senior Postdoctoral Fellow: Clare Scott, FRACP MB BS PhD Melb

Postdoctoral Fellow: Kirsteen Campbell, BSc(Hons) Glasgow PhD Dundee

Postdoctoral Fellow: Cassandra Vandenberg, BSc(Hons) PhD Otago

Postdoctoral Fellow: ¹Canny Sugiana BSc PhD

Postgraduate Student: ¹Lina Happo, BBiomedSc(Hons) Melb

 

Research Assistant: Sue Bath, BVSc Melb PhD ANU

Research Assistant: ¹Anuratha Srikumar, BSc Madras

¹Primary supervisor Clare Scott