Professor Suzanne Cory

Details

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Division: Molecular Genetics of Cancer

Research Overview

Our laboratory uses genetically modified mice to clarify the role of different oncogenic mutations in the development of leukaemia and lymphoma and responses to chemotherapy.

Research Interests

Selected Publications

  1. Campbell, KJ, Bath ML, Turner MT, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S. Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells and enhances drug-resistance. Blood 2010 Jul 14 [Epub ahead of print]
  2. Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17961-6 PMID: 19004807 [PubMed - indexed for MEDLINE]
  3. Adams JM, Cory S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Current Opinion in Immunology. 2007 Oct;19(5):488-96 PMID: 17629468 [PubMed - indexed for MEDLINE]
  4. Adams JM, Cory S. The Bcl-2 Apoptotic switch in cancer development and therapy. Oncogene. 2007 Feb 26;26(9):1324-37 PMID: 17322918 [PubMed - indexed for MEDLINE]
  5. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006 Nov;10(5):389-99 PMID: 17097561 [PubMed - indexed for MEDLINE]
  6. Cory S, Adams JM. Killing cancer cells by flipping the Bcl-2/Bax switch. Cancer Cell. 2005 Jul;8(1):5-6 PMID: 16023593 [PubMed - indexed for MEDLINE]
  7. Smith DP, Bath ML, Harris AW, Cory S. T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC. Oncogene. 2005 May 19;24(22):3544-53 PMID: 15688022 [PubMed - indexed for MEDLINE]
  8. Egle A, Harris AW, Bouillet P, Cory S. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6164-9 PMID: 15079075 [PubMed - indexed for MEDLINE]
  9. Egle A, Harris AW, Bath ML, O'Reilly L, Cory S. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood. 2004 Mar 15;103(6):2276-83 PMID: 14630790 [PubMed - indexed for MEDLINE]
  10. Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003 Nov 24;22(53):8590-607 PMID: 14634621 [PubMed - indexed for MEDLINE]

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Current Laboratory Members

Distinguished Research Fellow: Suzanne Cory AC MSc Melb PhD Cantab Hon DSc Syd Hon DSc Oxon FAA FRS

Postdoctoral Fellow: Rebecca Bilardi, BBiolSc(Hons) LaT PhD LaT

Postdoctoral Fellow: Cassandra Vandenberg, BSc(Hons) Otago PhD Otago

BSc Honours Student: Natasha Anstee, BSc Melb