Professor Phil Hodgkin
Details
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Division: Immunology
Research Overview
The regulation of immune response class by T and B lymphocytes.
The development of quantitative methods for measuring lymphocyte proliferation, survival and differentiation. Download supporting material here including the precursor cohort method and "Cyton Calculator".
The use of quantitative methods to dissect the effect of drugs, genetic polymorphisms and regulatory signals on the immune response to develop predictive models of system level outcomes.
Theoretical immunology.
Research Interests
- The importance of division progression in regulating lymphocyte differentiation
- Interpreting CFSE data
- Evasion of host immune responses
- Probabilistic regulation of cellular heterogeneity
Selected Publications
- Gett AV, Hodgkin PD. A cellular calculus for signal integration by T cells. Nat Immunol. 2000 Sep;1(3):239-44. PMID: 10973282 [PubMed - indexed for MEDLINE]
- Tangye SG, Ferguson A, Avery DT, Ma CS, Hodgkin PD. Isotype switching by human B cells is division-associated and regulated by cytokines.
J Immunol. 2002 Oct 15;169(8):4298-306. PMID: 12370361 [PubMed - indexed for MEDLINE] - Deenick EK, Gett AV, Hodgkin PD. Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J Immunol. 2003 May 15;170(10):4963-72. PMID: 12734339 [PubMed - indexed for MEDLINE]
- Hasbold J, Corcoran LM, Tarlinton DM, Tangye SG, Hodgkin PD. Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation.
Nat Immunol. 2004 Jan;5(1):55-63. PMID: 14647274 [PubMed - indexed for MEDLINE] - Kallies A, Hasbold J, Tarlinton DM, Dietrich W, Corcoran LM, Hodgkin PD, Nutt SL. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med. 2004 Oct 18;200(8):967-77. PMID: 15492122 [PubMed - indexed for MEDLINE]
- Corcoran LM, Hasbold J, Dietrich W, Hawkins E, Kallies A, Nutt SL, Tarlinton DM, Matthias P, Hodgkin PD. Differential requirement for OBF-1 during antibody-secreting cell differentiation.
J Exp Med. 2005 May 2;201(9):1385-96. PMID: 15867091 [PubMed - indexed for MEDLINE] - Baxter AG, Hodgkin PD. Activation rules: the two-signal theories of immune activation. Nat Rev Immunol. 2002 Jun;2(6):439-46. PMID: 12093010 [PubMed - indexed for MEDLINE]
- Hawkins ED, Markham JF, McGuiness LP, Hodgkin PD. A single-cell pedigree analysis of alternative stochastic lymphocyte fates. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13457-62. PMID: 19633185 [PubMed - indexed for MEDLINE] Data available for download here.
- Markham JF, Wellard CJ, Hawkins ED, Duffy KR, Hodgkin PD. A minimum of two heritable factors are required to explain the correlation structures in proliferating lymphocytes. Journal of the Royal Society Interface, in press. Pre-print version. Data available for download here.
Click here to view more PubMed publications
Current Laboratory Members
Faculty Member: Phil Hodgkin, BSc(Hons) UWA PhD ANU
Senior Postdoctoral Fellow: Susanne Heinzel PhD Tübingen
Senior Postdoctoral Fellow: Cameron Wellard, BSc(Hons) PhD Melb
Postdoctoral Fellow: Mark Dowling BA BSc(Hons) PhD Qld
Postdoctoral Fellow: Melinda Hardy BSc(Hons) Qld PhD Qld
Postdoctoral Fellow: Michael Inouye PhD Leiden
Postdoctoral Fellow: John Markham BEng Swinburne BSc(Hons) PhD Melb
Postdoctoral Fellow: Nadine Taubenheim PhD Albert-Ludwigs
Postdoctoral Fellow: Jason Tye-Din MB BS Melb PhD Melb FRACP
Postdoctoral Fellow: George Varigos
PhD Student: Julia Marchingo BSc (Hons) Melb
Research Assistant: Jie Zhou BSc Melb