Professor Jane Visvader

Details

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Division: Stem Cells and Cancer

Research Overview

Breast Cancer Laboratory

Our laboratory is interested in identifying transcriptional regulators that govern mammary gland development and whose perturbation leads to breast cancer.

By studying normal and malignant breast epithelial cells, our long-term goal is to identify markers and potential therapeutic targets against breast cancer.

The Breast Cancer Laboratory is jointly headed by Professor Jane Visvader and Professor Geoff Lindeman, and was originally established through support from the Victorian Breast Cancer Research Consortium.

Research Interests

Selected Publications

  1. Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, Deb S, Ritchie ME, Takano E, Ward T, Fox SB, Generali D, Smyth GK, Strasser A, Huang DC, Visvader JE, and Lindeman GJ. Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 Proceedings of the National Academy of Sciences USA 2011 Jul 18. [Epub ahead of print] PMID: 21768359
  2. Visvader JE (2011) Cells of origin in cancer. Nature. 469(7330):314-22 PMID: 21248838
  3. Asselin-Labat ML, Vaillant F, Sheridan J, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE. Control of mammary stem cell function by steroid hormone signalling. Nature. 2010 465(7299):798-8 PMID: 20383121 
  4. Lim E, Wu D, Pal B, Bouras T, Asselin-Labat M-L, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveals multiple conserved genes and pathways. Breast Cancer Research. 2010 12(2):R21. PMID :20346151
  5. Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat M-L, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine. 2009 15(8):907-13 PMID: 19648928
  6. Visvader JE. Keeping abreast of the mammary epithelial hierarchy and breast cancer. Genes Dev. 2009 23(22):2563-77. PMID: 19933147
  7. Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat M-L, Oakes SR, Lindeman GJ, Visvader JE. Notch signaling regulates mammary stem cell function and luminal cell fate commitment. Cell Stem Cell. 2008 3(4):429-41 PMID: 18940734
  8. Visvader JE and Lindeman GJ. Cancer Stem Cells in solid tumours: accumulating evidence and unresolved questions. Nature Reviews Cancer. 2008 8(10):755-68 PMID: 18784658
  9. Asselin-Labat M-L, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE. Gata-3 is an essential regulator of mammary gland morphogenesis and luminal cell differentiation. Nature Cell Biol. 2007 9(2):201-209 PMID: 17187062
  10. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat M-L,Wu L, Lindeman GJ, Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature. 2006 439:4-88 PMID: 16397499

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Current Laboratory Members

Laboratory Head: Geoff Lindeman MB BS(Hons) Syd BSc(Med) Syd PhD Melb FRACP

Laboratory Head: Jane Visvader BSc(Hons) Adelaide PhD Adelaide 

Postdoctoral Fellow: Delphine Merino MSc Dijon PhD Dijon

Postdoctoral Fellow: David Reynolds BSc(Hons) Adelaide PhD Adelaide

Postdoctoral Fellow: Francois Vaillant PhD Mon

Postdoctoral Fellow: Nai Yang Fu BSc MSc Sun Yat-sen PhD Singapor

Postdoctoral Fellow: Bhupinder Pal MSc Kurukshetra PhD Melb

Postdoctoral Fellow: Anne Rios PhD Marseille

Postdoctoral Fellow: Julie Sheridan BSc(Hons) Leeds PhD Edinburgh

Postdoctoral Fellow: Ewa Michalak BSc(Hons) UWA PhD Melb

Research Assistant: Kelsey Breslin BSc(Hons) Alberta

Research Assistant: Tamara McLennan BAppSc(Hons) QUT BBiolSc LaTrobe

Research Assistant: Catherine To BSc(Hons) Melb

Research Assistant: Kevin Liu BMed Beihua PhD Melb

Research Assistant: Felicity Jackling BSc(Hons) Melb

Postgraduate Student:Emma Nolan BSc(Hons) Otago

Postgraduate Student: Sarah Best BSc(Hons) Melb

Postgraduate Student: Bianca Capaldo BSc(Hons) Melb BSc Mon

Postgraduate Student: Lily Lee LLB(Hons) Melb BSc(Hons) Melb

Visiting Honours Student: Jeffrey Kam

Scientific Coordinator: Sally Cane BSc Deakin

Project Coordinator: Audrey Partanen BSc