Professor Geoff Lindeman
Details
Email: .(JavaScript must be enabled to view this email address)
Division: Stem Cells and Cancer
Research Overview
Breast Cancer Laboratory
Our laboratory is interested in identifying transcriptional regulators that govern mammary gland development and whose perturbation leads to breast cancer.
By studying normal and malignant breast epithelial cells, our long-term goal is to identify markers and potential therapeutic targets against breast cancer.
The Breast Cancer Laboratory is jointly headed by Professor Geoff Lindeman and Professor Jane Visvader, and was originally established through support from the Victorian Breast Cancer Research Consortium.
Research Interests
- The identification and characterisation of normal stem and progenitor cells in breast tissue
- The identification of "cells of origin" and cancer stem cells
- Role of master regulators in the mammary gland
- Physiological role of LM04 within the epithelial hierarchy and mechanisms by which it promotes breast cancer.
Selected Publications
- Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, Deb S, Ritchie ME, Takano E, Ward T, Fox SB, Generali D, Smyth GK, Strasser A, Huang DC, Visvader JE, and Lindeman GJ (2011). Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 Proceedings of the National Academy of Sciences USA Jul 18. [Epub ahead of print] (http://www.ncbi.nlm.nih.gov/pubmed/21768359)
- Lim E, Wu D, Pal B, Bouras T, Asselin-Labat M-L, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveals multiple conserved genes and pathways. Breast Cancer Research. 2010;12(2), R21. PMID: 20346151
- Asselin-Labat ML, Vaillant F, Sheridan J, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE. Control of mammary stem cell function by steroid hormone signalling. Nature 2010;465(7299), 798-8 PMID: 20383121
- Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat M-L, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine. 2009;15(8), 907-13 PMID: 19648928
- Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat M-L, Oakes SR, Lindeman GJ, Visvader JE. Notch signaling regulates mammary stem cell function and luminal cell fate commitment. Cell Stem Cell. 2008;3(4), 429-41 PMID: 18940734
- Visvader JE and Lindeman GJ. Cancer Stem Cells in solid tumours: accumulating evidence and unresolved questions. Nature Reviews Cancer. 2008;8(10), 755-68 PMID: 18784658
- Vaillant F, Asselin-Labat M-L, Shackleton M, Forrest NC, Lindeman GJ, Visvader JE. The mammary progenitor marker CD61/b3-integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Research. 2008;68(19), 7711-7 PMID: 18829523
- Asselin-Labat M-L, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE. Gata-3 is an essential regulator of mammary gland morphogenesis and luminal cell differentiation. Nature Cell Biol. 2007;9(2), 201-209 PMID: 17187062
- Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat M-L,Wu L, Lindeman GJ, Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature. 2006;439, 84-88 PMID: 16397499
- Visvader JE and Lindeman GJ. Mammary stem cells and mammopoiesis. Cancer Research. 2006;66(20), 9798-9801PMID: 17047038
Click here to view more PubMed publications
Current Laboratory Members
Laboratory Head: Jane Visvader BSc(Hons) Adelaide PhD Adelaide
Laboratory Head: Geoff Lindeman MB BS(Hons) Syd BSc(Med) Syd PhD Melb FRACP
Postdoctoral Fellow: Delphine Merino MSc Dijon PhD Dijon
Postdoctoral Fellow: David Reynolds BSc(Hons) Adelaide PhD Adelaide
Postdoctoral Fellow: Francois Vaillant PhD Mon
Postdoctoral Fellow: Nai Yang Fu BSc MSc Sun Yat-sen PhD Singapor
Postdoctoral Fellow: Bhupinder Pal MSc Kurukshetra PhD Melb
Postdoctoral Fellow: Anne Rios PhD Marseille
Postdoctoral Fellow: Julie Sheridan BSc(Hons) Leeds PhD Edinburgh
Postdoctoral Fellow: Ewa Michalak BSc(Hons) UWA PhD Melb
Research Assistant: Kelsey Breslin BSc(Hons) Alberta
Research Assistant: Tamara McLennan BAppSc(Hons) QUT BBiolSc LaTrobe
Research Assistant: Catherine To BSc(Hons) Melb
Research Assistant: Kevin Liu BMed Beihua PhD Melb
Research Assistant: Felicity Jackling BSc(Hons) Melb
Postgraduate Student:Emma Nolan BSc(Hons) Otago
Postgraduate Student: Sarah Best BSc(Hons) Melb
Postgraduate Student: Bianca Capaldo BSc(Hons) Melb BSc Mon
Postgraduate Student: Lily Lee LLB(Hons) Melb BSc(Hons) Melb
Visiting Honours Student: Jeffrey Kam
Scientific Coordinator: Sally Cane BSc Deakin
Project Coordinator: Audrey Partanen BSc
Project Officer: Kylie Shackleton BSc(Nursing) Deakin
