Professor Doug Hilton

Details

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Division: Molecular Medicine

Research Overview

The Hilton laboratory is interested in understanding the molecular regulation of cell proliferation and differentiation, with particular emphasis on the haematopoietic or blood cell forming system. We currently have two major programs, the first focussed on cytokines, their cell surface receptors and signal transduction pathways; the second focussed on uncovering pathways regulating hemopoiesis using a combination of forward and reverse mouse genetics, genomics, proteomics and bioinformatics. In addition to our basic research, the laboratory is committed to developing clinical links and to applying our research through collaboration with the biopharmaceutical industry.

Research Projects

Cytokines Receptors and Signal Transduction

Limiting cytokine action: Suppressors Of Cytokine Signalling (SOCS) Proteins

The SOCS Box; A link between generic and substrate-specific components of E3 ubiquitin ligases

Mouse Genetics

Defining Pathways

Major Publications

  1. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ.
    A family of cytokine-inducible inhibitors of signalling.
    Nature. 1997 Jun 26;387(6636):917-21 PMID: 9202125 [PubMed - indexed for MEDLINE]
  2. Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ.
    SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
    Cell. 1999 Sep 3;98(5):597-608 PMID: 10490099 [PubMed - indexed for MEDLINE]
  3. Croker BA, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts AW.
    SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
    Immunity. 2004 Feb;20(2):153-65 PMID: 14975238 [PubMed - indexed for MEDLINE]
  4. Carpinelli MR, Hilton DJ, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS.
    Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
    Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8 PMID: 15071178 [PubMed - indexed for MEDLINE]
  5. Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ.
    Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
    PLoS Biol. 2008 Apr 15;6(4):e93 PMID: 18416604 [PubMed - in process]

Click here to view more PubMed publications

Current Laboratory Members

Faculty Member: Doug Hilton, BSc Mon BSc(Hons) Melb FAA PhD Melb

Scientific Coordinator/Alliance Manager: Fiona McGrath, BAppSc(Hons) RMIT

Administrative Assistant: Maria Markovic, BA RMIT DipEd LaT

Senior Postdoctoral Fellow: Christine Biben

Senior Postdoctoral Fellow: Rachel Burt, BSc PhD Melb

Senior Postdoctoral Fellow: James Murphy, BSc(Hons) Canterbury PhD ANU

Senior Postdoctoral Fellow: Owen Prall

Senior Postdoctoral Fellow: Toby Sargeant, BComp(Hons) BSc MComp Mon PhD Melb

Senior Postdoctoral Fellow: Anne Verhagen

Senior Postdoctoral Fellow: Tracy Willson, BSc(Hons) PhD Mon

Senior Postdoctoral Fellow: Jian-Guo Zhang, BSc Xinjiang PhD Melb; jointly with Cancer and Haematology division

Senior Postdoctoral Fellow: Marnie Blewitt, BSc(Hons) PhD Syd

Postdoctoral Fellow: Marina Carpinelli

Postdoctoral Fellow: Marthe D'Ombrain

Postdoctoral Fellow: Aaron Robinson, BBiotech Flinders PhD Adelaide

Postdoctoral Fellow: Samir Taoudi

Computational Scientist: Jarny Choi, BSc(Hons) PhD Melb

Computational Scientist: James Wettenhall, BEng(Hons) BSc(Hons) Melb

Research Assistant: Tracey Baldwin, BAppSc RMIT

Research Assistant: Clare Morgan

Research Assistant: Miha Pakusch, BSc(Hons) Melb

Research Technician: Adrienne Hilton; jointly with Cancer and Haematology division

Research Technician: Michael Manning

Research Technician: Laura Raiti

Research Technician: Samuel Young 

Postgraduate Student: Carolyn de Graaf, BInfTech Swinburne BBiomedSc BSc(Hons) Melb

Postgraduate Student: Sarah Kinkel, BA BSc(Hons) Melb

Postgraduate Student: Huei Leong, BBiomedSc(Hons) Melb

Postgraduate Student: Leila Varghese, BSc(Hons) Melb

Honours Student: Kelan Chen,