Professor Doug Hilton
Details
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Division: Molecular Medicine
Research Overview
The Hilton laboratory is interested in understanding the molecular regulation of cell proliferation and differentiation, with particular emphasis on the haematopoietic or blood cell forming system. We currently have two major programs, the first focussed on cytokines, their cell surface receptors and signal transduction pathways; the second focussed on uncovering pathways regulating hemopoiesis using a combination of forward and reverse mouse genetics, genomics, proteomics and bioinformatics. In addition to our basic research, the laboratory is committed to developing clinical links and to applying our research through collaboration with the biopharmaceutical industry.
Research Projects
Cytokines Receptors and Signal Transduction
Limiting cytokine action: Suppressors Of Cytokine Signalling (SOCS) Proteins
The SOCS Box; A link between generic and substrate-specific components of E3 ubiquitin ligases
Major Publications
- Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ.
A family of cytokine-inducible inhibitors of signalling.
Nature. 1997 Jun 26;387(6636):917-21 PMID: 9202125 [PubMed - indexed for MEDLINE] - Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ.
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.
Cell. 1999 Sep 3;98(5):597-608 PMID: 10490099 [PubMed - indexed for MEDLINE] - Croker BA, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts AW.
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Immunity. 2004 Feb;20(2):153-65 PMID: 14975238 [PubMed - indexed for MEDLINE] - Carpinelli MR, Hilton DJ, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS.
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8 PMID: 15071178 [PubMed - indexed for MEDLINE] - Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ.
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
PLoS Biol. 2008 Apr 15;6(4):e93 PMID: 18416604 [PubMed - in process]
Click here to view more PubMed publications
Current Laboratory Members
Faculty Member: Doug Hilton, BSc Mon BSc(Hons) Melb FAA PhD Melb
Scientific Coordinator/Alliance Manager: Fiona McGrath, BAppSc(Hons) RMIT
Administrative Assistant: Maria Markovic, BA RMIT DipEd LaT
Senior Postdoctoral Fellow: Rachel Burt, BSc PhD Melb
Senior Postdoctoral Fellow: Toby Sargeant, BComp(Hons) BSc MComp Mon PhD Melb
Senior Postdoctoral Fellow: Tracy Willson, BSc(Hons) PhD Mon
Senior Postdoctoral Fellow: Jian-Guo Zhang, BSc Xinjiang PhD Melb
(Jointly with Cancer & Haematology Division)
Postdoctoral Fellow: Ann Cornish, BSc(Hons) PhD Melb
(Jointly with Autoimmunity & Transplantation Division)
Senior Postdoctoral Fellow: Marnie Blewitt, BSc(Hons) PhD Syd
Postdoctoral Fellow: Ian Majewski, BSc(Hons) UWA PhD Melb
Postdoctoral Fellow: James Murphy, BSc(Hons) Canterbury PhD ANU
Postdoctoral Fellow: Aaron Robinson, BBiotech Flinders PhD Adelaide
Postdoctoral Fellow: Gillian Tannahill, BSc(Hons) PhD Queen's
Computational Scientist: Jarny Choi, BSc(Hons) PhD Melb
Computational Scientist: James Wettenhall, BEng(Hons) BSc(Hons) Melb
Research Assistant: Tracey Baldwin, BAppSc RMIT
Research Assistant: Miha Pakusch, BSc(Hons) Melb
Postgraduate Student: Carolyn de Graaf, BInfTech Swinburne BBiomedSc BSc(Hons) Melb
Postgraduate Student: Kylie Greig, BSc(Hons) Melb
Postgraduate Student: Sarah Kinkel, BA BSc(Hons) Melb
Postgraduate Student: Huei Leong, BBiomedSc(Hons) Melb
Postgraduate Student: Lisa Mielke, BSc Melb
Research Assistant: Leila Varghese, BSc Melb