Professor Stephen Nutt

Details

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Division: Molecular Immunology

Research Overview

Lymphopoiesis is controlled by the co-ordinated activity of a handful of master regulatory transcription factors. Our research aims to investigate the functions of several such master regulators, PU.1, Pax5, c-Myb and Blimp-1 in lymphopoiesis and dendritic cell development using conditional mouse genetics, GFP reporter strains, microarray analysis and in vitro progenitor cultures.

Our specific research interests include:

  • the processes by which stem cells and early lymphoid lineage progenitors undergo commitment to particular pathways.
  • deciphering the genetic control of plasma cell differentiation
  • determining the role of Blimp-1 in effector and memory T cell differentiation
  • unraveling the transcriptional regulation of dendritic cell development and function

Research Interests

Selected Publications

  1. Nutt SL, Heavey B, Rolink AG, Busslinger M.  Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.  Nature. 1999 Oct 7;401(6753):556-62 PMID: 10524622 [PubMed - indexed for MEDLINE]
  2. Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL.  PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.  J Exp Med. 2005 May 2;201(9):1487-502 PMID: 15867096 [PubMed - indexed for MEDLINE]
  3. Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM, Hodgkin PD, Nutt SL.  Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.  Nat Immunol. 2006 May;7(5):466-74 PMID: 16565720 [PubMed - indexed for MEDLINE]
  4. Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D., McKenzie BS, Lew AM, Corcoran LM, Hodgkin PD, Tarlinton DM, Nutt SL.  Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.  Immunity. 2007 May;26(5): 555-566 PMID: 17509907 [PubMed - indexed for MEDLINE]
  5. Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A.  Tumor growth need not be driven by rare cancer stem cells.  Science. 2007 July; 317(5836): 337 PMID: 17641192 [PubMed - indexed for MEDLINE]
  6. Nutt SL, Fairfax KA, and Kallies A.  BLIMP1 guides the fate of effector B and T cells.  Nat Rev Immunol. 2007 December; 7(12):923-927 PMID: 17965637 [PubMed - indexed for MEDLINE]
  7. Nutt SL, and Kee BL.  The transcriptional regulation of B cell lineage commitment.  Immunity. 2007 June; 26(6):715-725 PMID: 17582344 [PubMed - indexed for MEDLINE]
  8. Kallies A, Xin A, Belz GT and Nutt SL.  Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses.  Immunity. 2009 August 31(2):283-295 PMID: 19664942 [PubMed - indexed for MEDLINE]
  9. Carotta S, Dakic A, D'Amico A, Pang SHM, Greig KT, Nutt SL, and Wu L.  The transcription factor P.U.1 controls dendritic cell development and Flt3 expression in a dose dependent manner.
    Immunity. 2010 32(5):628-641 PMID: 20510871 [PubMed - indexed for MEDLINE]

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Current Laboratory Members

Faculty Member: Stephen Nutt, BSc(Hons) Syd PhD Vienna

Senior Postdoctoral Fellow: Rhys Allan, BSc(Hons) PhD Melb

Senior Postdoctoral Fellow: Erika Cretney, BSc(Hons) PhD Melb

Senior Postdoctoral Fellow: Sheila Dias, BSc Lisbon, PhD Paris 6

Senior Postdoctoral Fellow: Simon Willis, BSc(Hons) PhD Melb

Postdoctoral Fellow: Michael Chopin, MSc Montpellier PhD Dresden

Postdoctoral Fellow: Aleksandar Dakic, BSc(Hons) PhD Melb

Postdoctoral Fellow: Julie Tellier, PhD France

Research Assistant: Patrick Leung, BBiomedSc BSc(Hons) Monash

Research Assistant: Nadia Innarella