Dr Stephen Nutt
Details
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Division: Molecular Immunology
Research Overview
Lymphopoiesis is controlled by the co-ordinated activity of a handful of master regulatory transcription factors. Our research aims to investigate the functions of several such master regulators, PU.1, Pax5, c-Myb and Blimp-1 in lymphopoiesis and dendritic cell development using conditional mouse genetics, GFP reporter strains, microarray analysis and in vitro progenitor cultures.
Our specific research interests include:
- the processes by which stem cells and early lymphoid lineage progenitors undergo commitment to particular pathways.
- deciphering the genetic control of plasma cell differentiation
- determining the role of Blimp-1 in effector and memory T cell differentiation
- unraveling the transcriptional regulation of dendritic cell development and function
Research Interests
- PU.1 is an essential regulator of hematopoiesis
- Transcriptional networks controlling B cell differentiation
- Blimp-1 regulates B and T cell terminal differentiation
- Control of dendritic cell development
Selected Publications
- Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999 Oct 7;401(6753):556-62 PMID: 10524622 [PubMed - indexed for MEDLINE]
- Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005 May 2;201(9):1487-502 PMID: 15867096 [PubMed - indexed for MEDLINE]
- Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM, Hodgkin PD, Nutt SL. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol. 2006 May;7(5):466-74 PMID: 16565720 [PubMed - indexed for MEDLINE]
- Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D., McKenzie BS, Lew AM, Corcoran LM, Hodgkin PD, Tarlinton DM, Nutt SL. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity. 2007 May;26(5): 555-566 PMID: 17509907 [PubMed - indexed for MEDLINE]
- Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. Tumor growth need not be driven by rare cancer stem cells. Science. 2007 July; 317(5836): 337 PMID: 17641192 [PubMed - indexed for MEDLINE]
- Nutt SL, Fairfax KA, and Kallies A. BLIMP1 guides the fate of effector B and T cells. Nat Rev Immunol. 2007 December; 7(12):923-927 PMID: 17965637 [PubMed - indexed for MEDLINE]
- Nutt SL, and Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity. 2007 June; 26(6):715-725 PMID: 17582344 [PubMed - indexed for MEDLINE]
- Kallies A, Xin A, Belz GT and Nutt SL. Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity. 2009 August 31(2):283-295 PMID: 19664942 [PubMed - indexed for MEDLINE]
- Carotta S, Dakic A, D'Amico A, Pang SHM, Greig KT, Nutt SL, and Wu L. The transcription factor P.U.1 controls dendritic cell development and Flt3 expression in a dose dependent manner.
Immunity. 2010 32(5):628-641 PMID: 20510871 [PubMed - indexed for MEDLINE]
Click here to view more PubMed publications
Current Laboratory Members
Faculty Member: Stephen Nutt, BSc(Hons) Syd PhD Vienna
Senior Postdoctoral Fellow: Rhys Allan, BSc(Hons) PhD Melb
Senior Postdoctoral Fellow: Erika Cretney, BSc(Hons) PhD Melb
Senior Postdoctoral Fellow: Sheila Dias, BSc Lisbon, PhD Paris 6
Senior Postdoctoral Fellow: Simon Willis, BSc(Hons) PhD Melb
Postdoctoral Fellow: Michael Chopin, MSc Montpellier PhD Dresden
Postdoctoral Fellow: Aleksandar Dakic, BSc(Hons) PhD Melb
Postdoctoral Fellow: Yoko Shimohakamada, PhD Tokyo
Research Assistant: Rebecca Thong, BBiomedSc(Hons) Melb
