The Walter and Eliza Hall Institute of Medical Research

Professor Phil Hodgkin

Details

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Division: Immunology

Research Overview

• The regulation of immune response class by T and B lymphocytes.
• The development of quantitative methods for measuring lymphocyte proliferation, survival and differentiation. Download supporting material here including the precursor cohort method and "Cyton Calculator"
• The use of quantitative methods to dissect the effect of drugs, genetic polymorphisms and regulatory signals on the immune response to develop predictive models of system level outcomes
• Theoretical immunology

Research Projects

The importance of division progression in regulating lymphocyte differentiation

Interpreting CFSE data

Evasion of host immune responses

Probabilistic regulation of cellular heterogeneity

Major Publications

1. Gett AV, Hodgkin PD.
   A cellular calculus for signal integration by T cells.
   Nat Immunol. 2000 Sep;1(3):239-44 PMID: 10973282 [PubMed - indexed for MEDLINE]
2. Tangye SG, Ferguson A, Avery DT, Ma CS, Hodgkin PD.
   Isotype switching by human B cells is division-associated and regulated by cytokines.
   J Immunol. 2002 Oct 15;169(8):4298-306 PMID: 12370361 [PubMed - indexed for MEDLINE]
3. Deenick EK, Gett AV, Hodgkin PD.
   Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival.
   J Immunol. 2003 May 15;170(10):4963-72 PMID: 12734339 [PubMed - indexed for MEDLINE]
4. Hasbold J, Corcoran LM, Tarlinton DM, Tangye SG, Hodgkin PD.
   Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation.
   Nat Immunol. 2004 Jan;5(1):55-63 PMID: 14647274 [PubMed - indexed for MEDLINE]
5. Kallies A, Hasbold J, Tarlinton DM, Dietrich W, Corcoran LM, Hodgkin PD, Nutt SL.
   Plasma cell ontogeny defined by quantitative changes in blimp-1 expression.
   J Exp Med. 2004 Oct 18;200(8):967-77 PMID: 15492122 [PubMed - indexed for MEDLINE]
6. Corcoran LM, Hasbold J, Dietrich W, Hawkins E, Kallies A, Nutt SL, Tarlinton DM, Matthias P, Hodgkin PD.
   Differential requirement for OBF-1 during antibody-secreting cell differentiation.
   J Exp Med. 2005 May 2;201(9):1385-96 PMID: 15867091 [PubMed - indexed for MEDLINE]
7. Hodgkin PD.
   Quantitative rules for lymphocyte regulation: the cellular calculus and decisions between tolerance and activation.
   Tissue Antigens. 2005 Oct;66(4):259-66 PMID: 16185320 [PubMed - indexed for MEDLINE]
8. Deenick EK, Hasbold J, Hodgkin PD.
   Decision criteria for resolving isotype switching conflicts by B cells.
   Eur J Immunol. 2005 Oct;35(10):2949-55 PMID: 16180247 [PubMed - indexed for MEDLINE]
9. Hodgkin PD.
   An antigen valence theory to explain the evolution and organization of the humoral immune response.
   Immunol Cell Biol. 1997 Dec;75(6):604-18 PMID: 9492200 [PubMed - indexed for MEDLINE]
10. Baxter AG, Hodgkin PD.
    Activation rules: the two-signal theories of immune activation.
    Nat Rev Immunol. 2002 Jun;2(6):439-46 PMID: 12093010 [PubMed - indexed for MEDLINE]
11. Hawkins ED, Markham JF, McGuiness LP, Hodgkin PD.
    A single-cell pedigree analysis of alternative stochastic lymphocyte fates
    Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13457-62 PMID: 19633185 [PubMed - indexed for MEDLINE]
    Data available for download here.
12. Markham JF, Wellard CJ, Hawkins ED, Duffy KR, Hodgkin PD.
    A minimum of two heritable factors are required to explain the correlation structures in proliferating lymphocytes
    Journal of the Royal Society Interface, in press.
    Pre-print version. Data available for download here.

 

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Current Laboratory Members

Faculty Member: Phil Hodgkin, BSc(Hons) UWA PhD ANU

Senior Postdoctoral Fellow: Has Hasbold, PhD Budapest

Senior Postdoctoral Fellow: Susanne Heinzel, PhD Tübingen

Senior Postdoctoral Fellow: Cameron Wellard, BSc(Hons) PhD Melb

Postdoctoral Fellow: Mark Dowling, BA BSc(Hons) PhD Qld

Postdoctoral Fellow: Michael Inouye, PhD Leiden

Postdoctoral Fellow: John Markham, BEng Swinburne BSc(Hons) PhD Melb

Postdoctoral Fellow: Nadine Taubenheim, PhD Albert-Ludwigs

Honours Student: Julia Marchingo

Undergraduate Student: Shireen Bhatt