The Walter and Eliza Hall Institute of Medical Research

Dr Melanie Bahlo

Details

Email: .(JavaScript must be enabled to view this email address)
Division: Bioinformatics

Research Overview

Melanie Bahlo is an applied statistician working in the areas of statistical genetics, bioinformatics and population genetics. Her main area of research is linkage mapping, in humans and mice. Other areas of interest are genome wide association studies and associated problems. She is currently involved in 3 GWAS: MS, Epilepsy and resistance to Hepatitis C treatment.

Her linkage mapping work has seen her map loci for diseases such as epilepsy and deafness. She is particularly interested in SNP chip technologies and how these can be applied to rare disorders.

Research Projects

Mapping loci in ENU mutants in mice in complex pedigrees

Investigation of DNA sharing in distantly related individuals

CNV analysis in pedigrees and connections to linkage studies

Statistical Genetics

Major Publications

1. Bahlo M, Stankovich J, Speed TP, Rubio JP, Burfoot RK, Foote SJ.
   Detecting genome wide haplotype sharing using SNP or microsatellite haplotype data.
   Hum Genet. 2006 Mar;119(1-2):38-50 PMID: 16362347 [PubMed - indexed for MEDLINE]
2. Clarke NF, Smith RL, Bahlo M, North KN.
   A novel X-linked form of congenital fiber-type disproportion.
   Ann Neurol. 2005 Nov;58(5):767-72 PMID: 16173074 [PubMed - indexed for MEDLINE]
3. Bahlo M, Xing L, Wilkinson CR.
   HumanMSD and MouseMSD: generating genetic maps for human and murine microsatellite markers.
   Bioinformatics. 2004 Nov 22;20(17):3280-3 PMID: 15217812 [PubMed - indexed for MEDLINE]
4. Knight MA, Gardner RJ, Bahlo M, Matsuura T, Dixon JA, Forrest SM, Storey E.
   Dominantly inherited ataxia and dysphonia with dentate calcification: spinocerebellar ataxia type 20.
   Brain. 2004 May;127(Pt 5):1172-81 PMID: 14998916 [PubMed - indexed for MEDLINE]
5. Rubio JP, Bahlo M, Tubridy N, Stankovich J, Burfoot R, Butzkueven H, Chapman C, Johnson L, Marriott M, Mraz G, Tait B, Wilkinson C, Taylor B, Speed TP, Foote SJ, Kilpatrick TJ.
   Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis.
   Hum Genet. 2004 May;114(6):573-80 PMID: 15014978 [PubMed - indexed for MEDLINE]
6. Rubio JP, Bahlo M, Butzkueven H, van Der Mei IA, Sale MM, Dickinson JL, Groom P, Johnson LJ, Simmons RD, Tait B, Varney M, Taylor B, Dwyer T, Williamson R, Gough NM, Kilpatrick TJ, Speed TP, Foote SJ.
   Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis.
   Am J Hum Genet. 2002 May;70(5):1125-37 PMID: 11923913 [PubMed - indexed for MEDLINE]

Click here to view more PubMed publications

Current Laboratory Members

Faculty Member: Melanie Bahlo, BSc(Hons) PhD Mon

Scientific Coordinator/Alliance Manager: Fiona McGrath, BAppSc(Hons) RMIT

(Jointly with Molecular Medicine Division)

Administrative Assistant: Maria Markovic, BA RMIT DipEd LaT

(Jointly with Molecular Medicine Division)

Senior Postdoctoral Fellow: Natalie Thorne, BSc(Hons) PhD Melb

Postdoctoral Fellow: Max Moldovan, MB QUT PhD Melb

Research Assistant: Catherine Bromhead, BSc(Hons) Melb

Visiting BSc(Honours) Student: Pete Hickey, BSc Melb