Dr Marie-Liesse Asselin-Labat
Details
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Division: Stem Cells and Cancer
Research Overview
Our laboratory is interested in studying the cellular and molecular mechanisms underlying lung development and lung cancer formation.
A prerequisite to identifying the cells of origin of lung cancers is the isolation and characterisation of the normal stem cell and the hierarchy of cells that exist in the lung.
We aim to identify master regulators of stem cells and tumour-initiating cells within the lung to identify new targets for the development of future lung cancer therapies.
Our work is conducted in collaboration with Dr Kate Sutherland's laboratory.
Research Interests
- Identification and characterisation of mouse and human lung stem cells
- Identification of cells of origin of lung cancers
- Characterisation of master regulator of lung development
Selected Publications
- Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE. Control of mammary stem cell function by steroid hormone signalling. Nature 2010 Jun 10;465(7299):798-802. PMID: 20383121
- Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveals multiple conserved genes and pathways. Breast Cancer Res 2010 Mar 26;12(2):R21. PMID:20346151
- Gyorki DE, Asselin-Labat ML, van Rooijen N, Lindeman GJ, Visvader JE. Resident macrophages influence stem cell activity in the mammary gland. Breast Cancer Res 2009;11(4):R62. PMID: 19706193
- Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ; kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009 Aug;15(8):907-13. PMID: 19648928
- Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR, Lindeman GJ, Visvader JE. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008 Oct 9;3(4):429-41. PMID: 18940734
- Vaillant F, Asselin-Labat ML , Shackleton M, Forrest N, Lindeman GJ and Visvader JE. The mammary progenitor marker CD61/β3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Research 2008 Oct 1;68(19):7711-7. PMID: 18829523
- Oakes SR., Naylor MJ., Asselin-Labat ML, Blazek KD., Gardiner-Garden M., Hilton HN., Kazlauskas M., Pritchard MA., Chodosh LA., Pfeffer PL., Lindeman GJ., Visvader JE., and Ormandy CJ.. (2008) The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev Mar 1;22(5):581-6. PMID: 18316476
- Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE. . (2007) Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol Feb;9(2):201-9. PMID: 17187062
- Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, Visvader JE, Lindeman GJ (2006). Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst Jul 19;98(14):1011-4. PMID: 16849684
- Shackleton M, Vaillant F, Simpson KJ, Stingl J Smyth, GK, Asselin-Labat ML, Wu L, Lindeman GJ and Visvader JE. (2006). Generation of a functional mammary gland from a single stem cell. Nature 439, 84-8. PMID: 16397499
Click here to view more PubMed publications
Current Laboratory Members
Faculty Member: Marie-Liesse Asselin-Labat, PharmaD, PhD, Paris
Postdoctoral Fellow: Aliaksei Holik, BSc(Hons) Edinburgh PhD Cardiff
Research Assistant: Kati Viitaniemi, MSc Helsinki
Postgraduate Student: Clare Weeden, BA(Hons) UWA BSc(Hons) UWA
Overseas Research Trainee: Gaelle Tachon
Honours Student: Laura Galvis Vargas
Project Coordinator: Audrey Partanen BSc
