Dr Jacqui Gulbis
Details
Email: .(JavaScript must be enabled to view this email address)
Division: Structural Biology
Research Overview
Cellular function is underpinned by the capacity to control the passage of molecules across membranes, and discrete macromolecular machineries have evolved for the transport of ions, metabolites and newly synthesised proteins.
Our chief interests lie in the mechanisms, regulation and interplay of systems facilitating membrane transport and cellular signalling, and the lab specifically focuses on two modes of molecular transport: protein translocation and ion conduction. To elucidate the mechanistic principles underpinning these systems we use X-ray crystallography as a central methodology for identification of systematic conformational changes of functional relevance.
Other projects in which we are involved include the leucine-rich repeat-containing G protein coupled receptors (in collaboration with the Visvader lab), and calcium signalling.
Research Interests
- Mechanisms controlling ion permeation in potassium channels
- Protein translocation to the mitochondria
Selected Publications
- Clarke OB, Caputo AT, Hill A, Vandenberg JI, Smith BJ and Gulbis JM. Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels. Cell 2010 141 1018-1029. PMID: 20564790
- Webb CT, Gorman MA, Lazarou M, Ryan MT, Gulbis JM. Crystal structure of the mitochondrial chaperone TIM9-10 reveals a six-bladed α-propeller. Molecular Cell. 2006 21 123-133 PMID: 16387659
- Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science. 2003 300 1922-1926 PMID: 12738871
Click here to view more PubMed publications
Current Laboratory Members
Faculty Member: Jacqueline Gulbis, BSc (Hons) PhD LaT
Postdoctoral Associate: Cornelia Ludwig, BSc (Hons) PhD Edinburgh
Postdoctoral Associate: Lukasz Kowalczyk, MSc PhD Gdansk
Research Assistant: Pauline Crewther, BSc (Hons) MSc Melb
Postgraduate Student: Oliver Clarke, BSc (Hons) Melb
UROP Student: Katrina Black (undergraduate) Melb