The Walter and Eliza Hall Institute of Medical Research

Dr Ian Street

Details

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Division: Chemical Biology

Research Overview

High Throughput Chemical Screening (HTCS) is a widely used and effective technology for bioactive compound discovery. The $5 million infrastructure funding provided by the Walter and Eliza Hall Institute and Bio21 in 2002 enabled the establishment of Australia’s first truly academic HTCS facility; at the time one of only a few operating in publicly funded institutions world-wide. The WEHI/Bio21 HTCS facility and chemical library (a unique collection of over 100,000 compounds) is housed in purpose built laboratories at the WEHI Biotechnology Centre and its objective is to enable translational research and promote the use of chemical libraries in basic research by providing cost-effective access to HTCS technology for the academic and biotechnology communities. Since its launch in 2003, over thirty screening campaigns have been completed. The collaborative projects conducted by the HTCS Facility cover diverse therapeutic indications such as, cancer, inflammation, asthma, depression and anxiety, immunosuppression, and tropical diseases such as malaria, leishmaniasis and trypanosomiasis.

High-throughput chemical screening (HTCS) facility

Research Interests

Currently the high-throughput chemical screening (HTCS) facility has a number of projects in progress covering a wide range of potential disease indications and research interests.

Selected Publications

1. Holloway, G. A, Charman, W, Fairlamb, AH, Brun, R,Kaiser, M, Kostewicz, E, Novello, PM, Parisot, JP, Richardson, J, Street, IP, Watson, KG,and Baell, JB. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrobial Agents and Chemotherapy (proof accepted) 2009
2. Falk, H., Connor, T., Parisot, J., and Street, I., A Homogeneous Assay for the Determination of Kinase Activity. 2009. Novello, P., Sovath, S., Connor, T., Sleebs, N., Hatzis, E., Moss, R., Yang, H., Falk, H., Lackovic, K., Parisot, J., and Street, I., Overview of High-Throughput Chemical Screening (HTCS) within Academia. Is This Model a Bona Fide Source of Projects for Drug Discovery? 2009.
3. Sleebs, N., Lackovic, K., Miles, C., Moss, R., Novello, P., Parisot, J., and I, S., Identification and Confirmation of Kinase Inhibitors Via High-Throughput Chemical Screening. 2009.
4. Lackovic, K., Asselin-Labat, M.-L., Holroyd, S., Sleebs, N., Barker, H., Lindeman, G., Visvader, J., Parisot, J., and Street, I., A High Throughput Chemical Screening Approach to Drug Discovery for Lmo4 Inhibitors. 2008.
5. Mugyenyi, C., Lackovic, K., Gicheru, N., Gatakaa, H., Fegan, G., Anders, R., Street, I., Williams, T., Marsh, K., and Beeson, J., The Acquisition and Maintenance of Antibodies against P-Falciparum Merozoite Antigens in Childhood. International Journal for Parasitology, 2008. 38: p. S86-S86
6. O'Connor, S., Andriambeloson, E., Huyard, B., Wagner, S., Sleebs, B., Bui, C., Kremmidiotis, G., Street, I., and Flynn, B., Bnc210 Is a Novel, Fast Acting Compound with Potent Anxiolytic Activity and No Side Effects. European Neuropsychopharmacology, 2008. 18: p. S495-S495
7. Andriambeloson, E., Wagner, S., Huyard, B., Sleebs, B., Quasi, N., Bui, C., O'Connor, S., and Street, I., Bnc-210: A Novel Compound with Potent Anxiolytic Activity. Behavioural Pharmacology, 2007. 18: p. S16-S16,
8. Camp, D., Avery, V., Street, I., and Quinn, R.J., Progress toward Establishing an Open Access Molecular Screening Capability in the Australasian Region. ACS Chemical Biology, 2007. 2(12): p. 764-767
9. Holloway, G.A., Baell, J.B., Fairlamb, A.H., Novello, P.M., Parisot, J.P., Richardson, J., Watson, K.G., and Street, I.P., Discovery of 2-Iminobenzimidazoles as a New Class of Trypanothione Reductase Inhibitor by High-Throughput Screening. Bioorganic & Medicinal Chemistry Letters, 2007. 17(5): p. 1422-1427

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Current Laboratory Members

Faculty Member: Ian Street, BSc(Hons) Sussex PhD British Columbia

Senior Postdoctoral Fellow: Kurt Lackovic, BAppSc(Hons) PhD LaTrobe

Postdoctoral Fellow: Hendrik Falk, PhD Freie Universitä, Berlin

Visiting Fellow: Greg Arndt, PhD University of Saskatchewan

Research Assistant: Hong Yang, PhD Norman Bethune

Research Assistant: Theresa Connor, BSc Simon Fraser University

Research Assistant: Caroline Miles, Msc(Hons) Auckland

Research Assistant: Patrizia Novello, BBiolSc(Hons) LaTrobe

Research Assistant: Rebecca Moss, BAppSc(Hons) RMIT

Research Assistant: Effie Hatzis, BSc Monash

Research Assistant: Nerida Sleebs, final yr Bachelor of Biotechnology and Innovation

Research Assistant Sosathya Sovath, BA University of Massachusetts Amherst