Professor Gabrielle Belz

Details

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Division: Molecular Immunology

Research Overview

Our specific research interests include:

  • Deciphering the genetic control of effector and memory T cell differentiation
  • Unravelling the transcriptional regulation of dendritic cell development and function
  • Determining the control of innate immune cell subsets and their contribution to protective immunity during infection
  • Transcriptional and molecular regulation of peripheral lymphocyte differentiation

We are currently studying the following research areas:

  • Development and specialization of dendritic cells
  • Id and E protein regulation of effector and memory T cell differentiation in infection
  • Transcriptional networks controlling T cell differentiation
  • Development and function of innate immune cells

Our research is focused on understanding how a subset of white blood cells, called cytotoxic T cells (CTL, or CD8 T cells), recognise and remove virally-infected cells from the body following infection. The aim is to identify specific factors that determine how virus-specific killer T cells develop during an infection and how they impact on the establishment of immune memory after virus infection.

Our laboratory uses a combination of cutting-edge cellular and molecular technologies to dissect and study virus-specific T cell responses to Influenza A and herpes viruses. These include techniques such as flow cytometry, cell sorting, PCR and imaging.

Selected Publications

    1. Seillet C, Huntington ND, Gangatirkar P, Axelsson E, Minnich M, Brady HJ, Busslinger M, Smyth MJ, Belz GT, Carotta S. Differential Requirement for Nfil3 during NK Cell Development. J Immunol. 2014 Mar 15;192(6):2667-76. PMID: 24532575
    2. Rankin LC, Groom JR, Chopin M, Herold MJ, Walker JA, Mielke LA, McKenzie AN, Carotta S, Nutt SL, Belz GT. The transcription factor T-bet is essential for the development of NKp46(+) innate lymphocytes via the Notch pathway. Nat Immunol. 2013 Apr;14(4):389-95. PMID: 23455676
    3. Masson F, Minnich M, Olshansky M, Bilic I, Mount AM, Kallies A, Speed TP, Busslinger M, Nutt SL, Belz GT. Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol. 2013 May 1;190(9):4585-94. PMID: 23536629
    4. Seillet C, Jackson JT, Markey KA, Brady HJ, Hill GR, Macdonald KP, Nutt SL, Belz GT. CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood. 2013 Feb 28;121(9):1574-83. PMID: 23297132
    5. Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 2012 Jul 12;487(7406):249-53. PMID: 22763435
    6. Belz GT, Nutt SL. Transcriptional programming of the dendritic cell network. Nat Rev Immunol. 2012 Jan 25;12(2):101-13. PMID: 22273772
    7. Jackson JT, Hu Y, Liu R, Masson F, D'Amico A, Carotta S, Xin A, Camilleri MJ, Mount AM, Kallies A, Wu L, Smyth GK, Nutt SL, Belz GT. Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages. EMBO J. 2011 May 17;30(13):2690-704. PMID: 21587207
    8. Kallies A, Xin A, Belz GT, Nutt SL. Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity. 2009 Aug 21;31(2):283-95. PMID: 19664942
    9. Allan RS, Smith CM, Belz GT, van Lint AL, Wakim LM, Heath WR, Carbone FR. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science. 2003 Sep 26;301(5641):1925-8 PMID: 14512632
    10. Belz GT, Smith CM, Kleinert L, Reading P, Brooks A, Shortman K, Carbone FR, Heath WR. Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5 PMID: 15163797

     

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      Current Laboratory Members

      Faculty Member: Gabrielle Belz, BVBiol BVSc PhD DVSc Qld

      Editorial Assistant, ICB: Simone Farrer, BSc(Hons) Monash MSc Melb

      PhD Student: Lucie Rankin, BASc BSc(Hons) Melb

      Postdoctoral Fellow: Lisa Mielke, BSc(Hons) Phd Melb

      Postdoctoral Fellow: Joanna Groom, BSc Applied Science CSU BSc(Hons) Melb PhD Sydney

      Postdoctoral Fellow: Cyril Seillet, BSc MSc PhD Toulouse

      Postdoctoral Fellow: Matthew Firth, MSc Guelph

      Research Assistant: Mary Camilleri, Dip AppSci VUT

      Ressearch Assistant: Sara Lamont, BBiolSc(Hons) LaTrobe