The Walter and Eliza Hall Institute of Medical Research

Dr Bob Anderson

Details

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Division: Immunology

Research Overview

Our long-term objective is to ensure that people with coeliac disease are diagnosed with the least delay and treated effectively with minimal inconvenience.

The aim of our research is to understand how gluten stimulates the immune system to cause coeliac disease.

Our hypothesis is that the T cells stimulated by gluten peptides causing coeliac disease can be tolerized through controlled, repeated administration of the most important T-cell stimulatory gluten peptides.

Through detailed mapping of the gluten peptides recognized by antibodies and T cells from patients with coeliac disease we are developing new experimental diagnostics and therapeutics. Through close relations with the Coeliac Society, health professionals, pharmaceutical development experts and commercialization we not only discover and develop valuable new diagnostics and therapeutics, we also test our discoveries in patients and translate these to patient care.

Research Interests

• Development of a vaccine for coeliac disease
• People, porridge, and peptides: Avenin toxicity in coeliac disease

Selected Publications

1. Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP, Hill AV, McCluskey J, Rossjohn J, Anderson RP. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci Transl Med. 2010 Jul 21;2(41):41ra51. PMID: 20650871 [PubMed - in process]
2. Henderson KN, Reid HH, Borg NA, Broughton SE, Huyton T, Anderson RP, McCluskey J, Rossjohn J.
   The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease.
   Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1021-5 PMID: 18084083 [PubMed - indexed for MEDLINE]
3. Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI, Purcell AW, Dudek NL, van Heel DA, McCluskey J, Rossjohn J, Anderson RP.
   A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.
   Immunity. 2007 Jul;27(1):23-34 PMID: 17629515 [PubMed - indexed for MEDLINE]
4. Anderson RP, van Heel DA, Tye-Din JA, Jewell DP, Hill AV.
   Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease.
   Gut. 2006 Apr;55(4):485-91 PMID: 16299041 [PubMed - indexed for MEDLINE]
5. Anderson RP. Coeliac disease. Aust Fam Physician. 2005 Apr;34(4):239-42 PMID: 15861743 [PubMed - indexed for MEDLINE]
6. Anderson RP, van Heel DA, Tye-Din JA, Barnardo M, Salio M, Jewell DP, Hill AV. T cells in peripheral blood after gluten challenge in coeliac disease.
   Gut. 2005 Sep;54(9):1217-23 PMID: 16099789 [PubMed - indexed for MEDLINE]
7. Beissbarth T, Tye-Din JA, Smyth GK, Speed TP, Anderson RP. A systematic approach for comprehensive T-cell epitope discovery using peptide libraries.
   Bioinformatics. 2005 Jun;21 Suppl 1:i29-37 PMID: 15961469 [PubMed - indexed for MEDLINE]
8. Bateman EA, Ferry BL, Hall A, Misbah SA, Anderson R, Kelleher P. IgA antibodies of coeliac disease patients recognise a dominant T cell epitope of A-gliadin.
   Gut. 2004 Sep;53(9):1274-8 PMID: 15306584 [PubMed - indexed for MEDLINE]

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