The Walter and Eliza Hall Institute of Medical Research

Associate Professor Geoff Lindeman

Details

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Division: Molecular Genetics of Cancer

Research Overview

The VBCRC Laboratory Overview

Our laboratory is interested in identifying transcriptional regulators that govern mammary gland development and whose perturbation leads to breast cancer.

By studying normal and malignant breast epithelial cells, our long-term goal is to identify markers and potential therapeutic targets against breast cancer.

The Victorian Breast Cancer Research Consortium Laboratory is jointly headed Associate Professor Jane Visvader.

Laboratory Information

Research Projects

The identification and characterisation of normal stem and progenitor cells in breast tissue and cancer stem cells

Role of the GATA-3 transcription factor, a defining marker of the luminal subtypes of breast cancer, in the mammary gland

LMO4, a cofactor which interacts with the breast tumour suppressor BRCA1. High levels of LMO4 promote cellular proliferation and invasion and predict poor outcome in breast cancer

SOCS genes, which are negative regulators of prolactin and other cytokine signalling pathways in the breast

Major Publications

1. Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ; kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ.
   Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.
   Nat Med. 2009 Aug;15(8):907-13. Epub 2009 Aug 2. PMID: 19648928 [PubMed - indexed for MEDLINE]
2. Visvader JE, Lindeman GJ.
   Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.
   Nat Rev Cancer. 2008 Oct;8(10):755-68. Epub 2008 Sep 11. Review.
   PMID: 18784658 [PubMed - indexed for MEDLINE]
3. Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE.
   Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
   Nat Cell Biol. 2007 Feb;9(2):201-9 PMID: 17187062 [PubMed - indexed for MEDLINE]
4. Visvader JE, Lindeman GJ.
   Mammary stem cells and mammopoiesis.
   Cancer Res. 2006 Oct 15;66(20):9798-801 PMID: 17047038 [PubMed - indexed for MEDLINE]
5. Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, Visvader JE, Lindeman GJ.
   Steroid hormone receptor status of mouse mammary stem cells.
   J Natl Cancer Inst. 2006 Jul 19;98(14):1011-4 PMID: 16849684 [PubMed - indexed for MEDLINE]
6. Lindeman GJ, Visvader JE.
   Shedding light on mammary stem cells and tumorigenesis.
   Cell Cycle. 2006 Apr;5(7):671-2 PMID: 16582630 [PubMed - indexed for MEDLINE]
7. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE.
   Generation of a functional mammary gland from a single stem cell.
   Nature. 2006 Jan 5;439(7072):84-8 PMID: 16397499 [PubMed - indexed for MEDLINE]
8. Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, Lindeman GJ, Visvader JE.
   Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.
   Proc Natl Acad Sci U S A. 2005 May 24;102(21):7659-64 PMID: 15897450 [PubMed - indexed for MEDLINE]
9. Sum EY, Shackleton M, Hahm K, Thomas RM, O'Reilly LA, Wagner KU, Lindeman GJ, Visvader JE.
   Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.
   Oncogene. 2005 Jul 14;24(30):4820-8 PMID: 15856027 [PubMed - indexed for MEDLINE]
10. Olayioye MA, Kaufmann H, Pakusch M, Vaux DL, Lindeman GJ, Visvader JE.
    XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland.
    Cell Death Differ. 2005 Jan;12(1):87-90 PMID: 15540113 [PubMed - indexed for MEDLINE]
11. Sutherland KD, Lindeman GJ, Choong DY, Wittlin S, Brentzell L, Phillips W, Campbell IG, Visvader JE.
    Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.
    Oncogene. 2004 Oct 7;23(46):7726-33 PMID: 15361843 [PubMed - indexed for MEDLINE]
12. Lindeman GJ, Hiew M, Visvader JE, Leary J, Field M, Gaff CL, Gardner RJ, Trainor K, Cheetham G, Suthers G, Kirk J.
    Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
    Breast Cancer Res. 2004;6(4):R401-7 PMID: 15217508 [PubMed - indexed for MEDLINE]

Click here to view more PubMed publications

Current Laboratory Members

Faculty Member: Geoff Lindeman, BSc(Med) Syd FRACP MB BS(Hons) Syd PhD Melb

Faculty Member: Jane Visvader, BSc(Hons) PhD Adelaide

Senior Postdoctoral Fellow: Marie-Liesse Asselin-Labat, PhD Paris

Senior Postdoctoral Fellow: Francois Vaillant, PhD Mon

Postdoctoral Fellow: Toula Bouras, BSc(Hons) PhD Melb

Postdoctoral Fellow: Gwyndolen Harburg, BSc California MSc PhD Texas

Postdoctoral Fellow: Samantha Oakes, BSc(Hons) PhD UNSW

Postdoctoral Fellow: Bhupinder Pal, MSc Kurukshetra

Postdoctoral Fellow: Julie Sheridan, BSc(Hons) Leeds PhD Edinburgh

Research Techncian: Kelsey Haunholter, BSc(Hons) Alberta

Research Assistant: Teresa Ward, BSc(Hons) Massey