Professor David Tarlinton


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Division: Immunology

Research Overview

Immunising animals with a virus, a bacterium, a protein or a vaccine, generates an immunological memory that comprises long lived antibody secreting cells and recirculating memory cells. The antibody secreting cells persist for many years in bone marrow, while the quiescent memory B cells recirculate, but can be activated by re-exposure to the original antigen, rapidly increasing in number and differentiating into antibody secreting cells. Key proteins regulating lymphocyte differentiation and survival in response to antigen have been identified and understanding their activity in vivo, will be central to understanding the regulation of the immune system and the maintenance of immunological memory.

In some circumstances activation of the immune system is inappropriate and can cause or exacerbate auto-immune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Alterations in the manner in which B lymphocytes sense and respond to antigen are associated with the development of certain antibody-mediated autoimmune diseases. Analysis of B lymphocytes with such altered sensing provide insights into potential causes of disease and thus potential therapeutic targets.

Research Interests

Selected Publications

    1. Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, Nutt SL, Tarlinton DM. IL-21 Regulates Germinal Center B Cell Differentiation and Proliferation Through a B Cell-intrinsic Mechanism. J Exp Med. 2010 Feb 15;207(2):365-78. PMID: 20142430
    2. Carrington EM, Vikstrom IB, Light A, Sutherland RM, Londrigan SL, Mason KD, Huang DC, Lew AM, Tarlinton DM. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10967-71. PMID: 20534453
    3. Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM. Mcl-1 is essential for germinal center formation and memory. Science. 2010 Nov 19;330(6007):1095-9. PMID: 20929728
    4. Clybouw C, Fischer S, Auffredou MT, Hugues P, Alexia C, Bouillet P, Raphael M, Leca G, Strasser A, Tarlinton DM, Vazquez A. Regulation of memory B-cell survival by the BH3-only protein Puma. Blood. 2011 Oct 13;118(15):4120-8. PMID: 21868573
    5. Jones SA, White CA, Robb L, Alexander WS, Tarlinton DM. SOCS3 deletion in B cells alters cytokine responses and germinal center output. J Immunol. 2011 Dec 15;187(12):6318-26. PMID: 22075701
    6. Lüthje K, Kallies A, Shimohakamada Y, TBelz GT, Light A, Tarlinton DM, Nutt SL. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol. 2012 May;13(5):491-8. PMID: 22466669
    7. Jurado S, Gleeson K, O'Donnell K, Izon DJ, Walkley CR, Strasser A, Tarlinton DM, Heierhorst J. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. J Exp Med. 2012 Aug 27;209(9):1629-39. PMID: 22891272
    8. Tsantikos E, Maxwell MJ, Kountouri N, Harder KW, Tarlinton DM, Hibbs ML. Genetic interdependence of lyn and negative regulators of B cell receptor signaling in autoimmune disease development. J Immunol. 2012 Aug 15;189(4):1726-36. PMID: 22798664

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      Current Laboratory Members

      Faculty Member: David Tarlinton, BSc(Hons) Syd PhD Stanford

      Postdoctoral Fellow: Simona Infantino, PhD Bellinzoma

      Postdoctoral Fellow: Kim Jacobson, BSc(Hons) Tech Syd PhD Syd

      Postdoctoral Fellow: Ingela Vikstrom, MSc PhD Ume

      Postdoctoral Fellow:Dimitra Zotos, BBiomedSc(Hons) Deakin

      Research Assistant: Catherine Chang,

      Research Assistant: Lingli Li,

      Research Assistant: Amanda Light, BAppSc RMIT

      Research Assistant: Kristy O'Donnell, BAppSc RMIT BSc(Hons) Melb

      Postgraduate Student: Ivan Fung, BSc(Hons) Melb

      Honours Student: Mark Li, BBiomedSc Melb