Associate Professor Clare Scott
Division: Stem Cells and Cancer
Each year, more than 1,200 Australian women are diagnosed with ovarian cancer; around 800 will die from the disease. On average three Australian women are diagnosed every day. Ovarian cancer is the sixth major cause of cancer mortality in Australian women. Because it is difficult to diagnose early and despite a small improvement in survival over the last 20 years, only 40% of women diagnosed with ovarian cancer are alive five years later (AIHW and NBOCC 2010).
Despite efforts to develop screening tools, 80% of EOC are diagnosed after they have spread beyond the ovary and 70% are generally incurable. Because ovarian cancer becomes resistant to current therapies so often, it is essential that we discover new treatments.
As a clinician scientist, a laboratory head of an ovarian cancer laboratory in the ACRF Stem Cells and Cancer division (funded by the Cory Leadership Fellowship) and laboratory head in the Molecular Genetics of Cancer division, my research concentrates on developing new mouse models of epithelial ovarian cancer in order to improve molecular testing of ovarian cancer, producing new treatment strategies.
Ovarian cancer laboratory
- Epithelial ovarian cancer program
- DNA damage-induced oocyte apoptosis and fertility loss requires p63-mediated induction of Puma and Noxa
- Happo L, Cragg MS, Phipson P, Haga JM, Jansen EJ, Herold MJ, Dewson G, Michalak EM, Vandenberg CJ, Smyth GK, Strasser A, Cory S and Scott CL. Maximal killing of lymphoma cells by DNA-damage inducing therapy requires not only the p53 targets Puma and Noxa but also Bim. Blood Epub ahead of print September 10 2010.
- Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A*, Adams JM*, Scott CL* (2009) Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. *these authors share senior authorship. Cell Death Differ 16: 684-96. PMID: 19148184
- Cragg MS*, Jansen ES, Cook M, Strasser A*, Scott CL* (2008) Treatment of B-Raf mutant human tumour cells with a MEK inhibitor requires Bim and is enhanced by a BH3-mimetic. *these authors share senior authorship. J Clin Invest 118: 3651-9. PMID: 18949058
- Cragg, MS, Harris, C, Strasser A, Scott CL (2009) Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nature Reviews Cancer 9: 321-6. PMID: 19343035
- Mason KD*, Vandenberg CJ*, Scott CL, Wei A, Cory S, Huang DCS, Roberts AW (2008) In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. *these authors contributed equally. Proc Natl Acad Sci U S A 105: 17961-6. PMID: 19004807
- Scott CL*, Gil J*, Hernando E, Teruya-Feldstein J, Narita M, Martinez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW (2007) Role of the chromobox protein CBX7 in lymphomagenesis. *these authors contributed equally. Proc Natl Acad Sci U S A. 104: 5389-94. PMID: 17374722
- Van Delft MF, Wei AH, Mason KD, Vandenberg C, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams J, Roberts AW, Huang DCS (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10: 389-99. PMID: 17097561
- James PA, Doherty R, Harris M, Mukesh BN, Milner A, Young M-A, Scott CL (2006) Optimal Selection of Individuals for BRCA Mutation Testing: A Comparison of Available Methods. J Clin Oncol 24: 707-715. PMID: 16446345
- Scott CL, Schuler M, Marsden V, Egle A, Pellegrini M, Nesic D, Gerondakis S, Nutt SL, Green D, Strasser A (2004) Apaf-1 and Caspase 9 do not act as tumour suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol 164: 89-96. PMID: 14709542
- Scott CL, Hughes DA, Cary D, Nicola NA, Begley CG, Robb L (1998) Functional analysis of mature hematopoietic cells from mice lacking the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. Blood 92: 4119-4127. PMID: 9834217
Current Laboratory Members
Laboratory Head: Clare Scott MB BS Melbourne PhD Melbourne FRACP
Research Assistant: Michele Cook Dip App Sci (Medical Laboratory Science) RMIT
Research Assistant: Lina Happo BBiomedSc(Hons) Melbourne
Research Assistant: Lynne Hartley BSc(Hons) Melbourne GradDipAcc Monash
Research Assistant: Emma Boehm BSc Melb
Postgraduate Student: Valerie Heong MB BS Adelaide
Postgraduate Student: Monique Topp BMedSci
Undergraduate Student: Elizabeth Lieschke BMedSci Melb MB BS Melb PhD Melb FRACP