Analysis of CARP1 and CARP2 KO mice
Project type
Honours
| Supervisor(s) | Division | |
| (Primary) | Cell Signalling and Cell Death | .(JavaScript must be enabled to view this email address) |
Dr Najoua Lalaoui (Co-supervisor) |
Cell Signalling and Cell Death | .(JavaScript must be enabled to view this email address) |
Dr James Vince (Co-supervisor) |
Cell Signalling and Cell Death | .(JavaScript must be enabled to view this email address) |
Details of project
The proteins CARP1 and CARP2 have been proposed to act as inhibitors of cell death that bind to caspase 8 and cause it to be ubiquitylated and degraded. The RING domains of these proteins closely resemble those of cIAPs and the p53 regulators MDM2 and MDM4.
To determine the roles and functions of CARP1 and CARP2 we have created gene KO mice. The goal of this Honours project is to help characterise these mice.
Research interests
Molecular mechanisms of programmed cell death; regulation of signalling by members of the TNF superfamily.
Research theme
Cancer
Scientific discipline
- Cell Biology
Keywords
apoptosis, CARP1 RING, caspase