Early Discoveries
The most significant discoveries made in the early years include:
Venoms and anti-venenes
Kellaway and collaborators, including Neil Hamilton Fairley, characterised the pharmacological activity of venoms from Australian snakes, which was progressed with CSL to produce first anti-venene. Their legacy is the availability of effective anti-venenes for snakes and other venomous creatures around Australia today.
- Kellaway CH 1937 Snake venoms 1. Their constitution and therapeutic applications Bull Johns Hopkins Hosp 60 1-17
- Kellaway CH 1937 Snake venoms II. Their peripheral action Bull Johns Hopkins Hosp 60 18-39
- Kellaway CH 1937 Snake venoms III. Immunity Bull Johns Hopkins Hosp 60 159-177
- Kellaway CH 1939 Animal poisons Ann Rev Biochemistry 8 541-556
Discovery of SRS-A, the slow reactive substance of anaphylaxis
Research by Kellaway and ER Trethewie on the cause of the tissue injury provoked by venoms led to the discovery of SRS-A, the slow reactive substance of anaphylaxis. SRS-A was identified in the 1980s to be the cysteinyl leukotrienes, which are a thousand times more powerful than histamine or serotonin and play a major role in inflammatory responses.
- Kellaway CH and Trethewie ER 1940 The liberation of slow-reacting smooth muscle stimulating substance in anaphylaxis Quarterly J of Exp Physiol 30 121-45