Plasmodium falciparum isolate origins

This provides information about the first decription of some of the commonly used laboratory strains of Plasmodium falciparum. Included is the country of origin (sometimes presumed) and the original reference. I would like as many updates and contributions as possible.

Plasmodium falciparum origins
Strain Country Comment Reference
3D7 Airport Malaria Cloned line derived from NF54 by limiting dilution. Rosario, V. (1981) Cloning of naturally occurring mixed infections of malaria parasites. Science 212, 1037-1038.
7G8 Brazil Clone derived from isolate IMTM 22 Burkot, T. R., Williams, J.L. and Schneider, I. (1984) Infectivity to mosquitoes of Plasmodium falciparum clones grown in vitro from the same isolate. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 339-341.
FC27 Papua New Guinea Is the origin of many daughter cloned lines including D10 and E12 Chen, P., Lamont, G., Elliott, T., Kidson, C., Brown, G. and Mitchell, G. (1980) Plasmodium falciparum strains from Papua New Guinea: culture characteristics and drug sensitivity. Southeast Asian J Trop Med Public Health 11, 435-440.
HB3 Honduras Cloned line derived by microscopic selection from the isolate H1. William Trager
NF7 ?Ghana Isolate from Ghanaian patient, living in the Netherlands but who had recently visited Ghana. First isolated into culture on 13 Jan. 1978. Ponnudurai, T., Leeuwenberg, A.D.E.M. and Meuwissen, J.H.E.Th. (1981) Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Tropical and Geographical Medicine 33, 50-54.
NF54 Airport Malaria Is the origin of the human vaccine challenge line 3D7. Isolated from an individual living near Schipol Airport, Amsterdam, The Netherlands. Ponnudurai, T., Leeuwenberg, A. D. and Meuwissen, J. H. (1981) Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Tropical and Geographical Medicine 33, 50-54.

**Plasmodium falciparum origins**
Strain	Country	Comment	Reference
3D7	Airport Malaria	Cloned line derived from NF54 by limiting dilution.	Rosario, V. (1981) Cloning of naturally occurring mixed infections of malaria parasites. Science 212, 1037-1038.
7G8	Brazil	Clone derived from isolate IMTM 22	Burkot, T. R., Williams, J.L. and Schneider, I. (1984) Infectivity to mosquitoes of Plasmodium falciparum clones grown in vitro from the same isolate. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 339-341.
FC27	Papua New Guinea	Is the origin of many daughter cloned lines including D10 and E12	Chen, P., Lamont, G., Elliott, T., Kidson, C., Brown, G. and Mitchell, G. (1980) Plasmodium falciparum strains from Papua New Guinea: culture characteristics and drug sensitivity. Southeast Asian J Trop Med Public Health 11, 435-440.
HB3	Honduras	Cloned line derived by microscopic selection from the isolate H1.	William Trager
NF7	?Ghana	Isolate from Ghanaian patient, living in the Netherlands but who had recently visited Ghana. First isolated into culture on 13 Jan. 1978.	Ponnudurai, T., Leeuwenberg, A.D.E.M. and Meuwissen, J.H.E.Th. (1981) Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Tropical and Geographical Medicine 33, 50-54.
NF54	Airport Malaria	Is the origin of the human vaccine challenge line 3D7. Isolated from an individual living near Schipol Airport, Amsterdam, The Netherlands.	Ponnudurai, T., Leeuwenberg, A. D. and Meuwissen, J. H. (1981) Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Tropical and Geographical Medicine 33, 50-54.

Last Updated: 10/9/97

Analyst/Contact: Ross Coppel

If you have some additional information, drop me a line

E-Mail Address: ross.coppel@med.monash.edu.au

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