Circumsporozoite protein 1 (CDS-1) Aggarwal, A., S. Kumar et al. (1990). "Oral Salmonella: Malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells." J Exp Med 172: 1083-1090. Aidoo, M., A. Lalvani et al. (1995). "Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria." Lancet 345(8956): 1003-1007. Ak, M., J. H. Bower et al. (1993). "Monoclonal antibodies of three different immunoglobulin G isotypes produced by immunization with a synthetic peptide or native protein protect mice against challenge with Plasmodium yoelii sporozoites." Infect Immun 61(6): 2493-2497. Akanmori, B. D., E. A. Afari et al. (1995). "A longitudinal study of malaria infection, morbidity and antibody titres in infants of a rural community in Ghana." Trans R Soc Trop Med Hyg 89(5): 560- 561. Alexander, J., J. Fikes et al. (1998). "The optimization of helper T lymphocyte (HTL) function in vaccine development." Immunol Res 18(2): 79-92. Aley, S. B., M. D. Bates et al. (1986). "Synthetic peptides from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium knowlesi recognize the human hepatoma cell line HepG2- A16 in vitro." J Exp Med 164: 1915-1922. Aley, S. B., C. T. Atkinson et al. (1987). "Ultrastructural localization of Plasmodium falciparum circumsporozoite protein in newly invaded hepatoma cells." J Parasitol 73(1241): 1241-1245. Altaba, A. R. I., L. S. Ozaki et al. (1987). "Organization and expression of the Plasmodium knowlesi circumsporozoite antigen gene." Mol Biochem Parasitol 23: 233-245. Alving, C. R. and R. L. Richards (1990). "Liposomes containing lipid A: a potent nontoxic adjuvant for a human malaria sporozoite vaccine." Immunol Lett 25: 275-279. Andersen, E., T. R. Jones et al. (1997). "Assessment of age- dependent immunity to malaria in transmigrants." Am J Trop Med Hyg 56(6): 647-649. Anker, R., F. Zavala et al. (1990). "VH and VL region structure of antibodies that recognize the (NANP)3 dodecapeptide sequence in the circumsporozoite protein of Plasmodium falciparum." Eur J Immunol 20(12): 2757-2761. Ardeshir, F., R. F. Howard et al. (1990). "Cross-reactive asparagine-rich determinants shared between several blood-stage antigens of Plasmodium falciparum and the circumsporozoite protein." Mol Biochem Parasitol 40(1): 113-28. Armah, G. E., S. Nishikawa et al. (1988). "The synthesis, cloning and expression of a repeating segment of the circumsporozoite surface protein of Plasmodium falciparum." Nucl Acids Symp Ser 0(165): 165-169. Armah, G. E., S. Nishikawa et al. (1990). "Conformation and immunogenicity of engineered repeating segment of the circumsporozoite surface protein of Plasmodium falciparum." Mol Biochem Parasitol 38(1): 135-140. Arnot, D. E., J. W. Barnwell et al. (1985). "Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope." Science 230: 815-818. Arnot, D. E., J. W. Barnwell et al. (1988). "Does biased gene conversion influence polymorphism in the circumsporozoite protein- encoding gene of Plasmodium vivax." Proc Natl Acad Sci USA 85: 8102-8106. Arnot, D. E., M. J. Stewart et al. (1990). "Antigenic diversity in Thai Plasmodium vivax circumsporozoite proteins." Mol Biochem Parasitol 43: 147-150. Arnot, D. E., C. Roper et al. (1993). "Digital codes from hypervariable tandemly repeated DNA sequences in the Plasmodium falciparum circumsporozoite gene can genetically barcode isolates." Mol Biochem Parasitol 61(1): 15-24. Arnot, D. E., C. Roper et al. (1994). "MVR-PCR analysis of hypervariable DNA sequence variation." Parasitol Today 10(8): 324- 327. Astagneau, P., R. W. Steketee et al. (1994). "Antibodies to ring- infected erythrocyte surface antigen (Pf155/RESA) protect against P.falciparum parasitemia in highly exposed multigravidas women in Malawi." Acta Trop 57(4): 317-325. Atkinson, C. T., M. Aikawa et al. (1989). "Expression of Plasmodium berghei circumsporozoite antigen on the surface of exoerythrocytic schizonts and merozoites." Am J Trop Med Hyg 41(9): 9-17. Atkinson, C. T., P. Millet et al. (1989). "Localization of circumsporozoite antigen in exoerythrocytic schizonts of Plasmodium cynomolgi." Am J Trop Med Hyg 40(131): 131-140. Ballou, W. R., J. Rothbard et al. (1985). "Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum." Science 228: 996-999. Ballou, W. R., S. L. Hoffman et al. (1987). "Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine." Lancet i: 1277-1281. Barragan, A., D. Spillmann et al. (1999). "Role of glycans in Plasmodium falciparum infection." Biochem Soc Trans 27(4): 487- 493. Barrios, C., A. R. Lussow et al. (1992). "Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming." Eur J Immunol 22(6): 1365-1372. Beier, J. C. (1993). "Malaria sporozoites: survival, transmission and disease control." Parasitol Today 9(6): 210-215. Berzofsky, J. A. (1991). "Mechanisms of T-cell recognition with application to vaccine design." Mol Immunol 28(3): 217-223. Bharadwaj, A., P. Sharma et al. (1997). "Immunogenicity of synthetic peptides containing multiple epitopes from malaria antigens." Ann Trop Med Parasitol 91(Suppl. 1): S19-S20. Bhattacharya, P. R. (1999). "Genetic polymorphism in T-cell epitopes of the circumsporozoite protein of Plasmodium falciparum clones and isolates from India." Trans Roy Soc Trop Med Hyg 93(2): 204-207. Billetta, R., M. R. Hollingdale et al. (1991). "Immunogenicity of an engineered internal image antibody." Proc Natl Acad Sci USA 88(11): 4713-4717. Bilsborough, J., K. Baumgart et al. (1997). "Fine epitope specificity of antibodies to region II of the Plasmodium vivax circumsporozoite protein correlates with ability to bind recombinant protein and sporozoites." Acta Trop 65(2): 59-80. Bisang, C., C. Weber et al. (1995). "Stabilization of type-I b- turn conformations in peptides containing the NPNA-repeat motif of the Plasmodium falciparum circumsporozoite protein by substituting proline for (S)-a-methylproline." J Am Chem Soc 117(30): 7904- 7915. Bisang, C., L. Y. Jiang et al. (1998). "Synthesis, conformational properties, and immunogenicity of a cyclic template-bound peptide mimetic containing an NPNA motif from the circumsporozoite protein of Plasmodium falciparum." J Am Chem Soc 120(30): 7439-7449. Blum-Tirouvanziam, U., C. Beghdadi-Rais et al. (1994). "Elicitation of specific cytotoxic T cells by immunization with malaria soluble synthetic polypeptides." J Immunol 153(9): 4134- 4141. Boudin, C., I. Sheick et al. (1994). "The multifactorial and multistage character of protective immunity toPlasmodium falciparum, naturally acquired by an indigenous population in Burkina Faso." Scand J Immunol 39: 409-417. Boulanger, N., H. Matile et al. (1988). "Formation of the circumsporozoite protein of Plasmodium falciparum in Anopheles stephensi." Acta Trop (Basel) 45(55): 55-65. Braga, E. M., C. J. F. Fontes et al. (1998). "Persistence of humoral response against sporozoite and blood-stage malaria antigens 7 years after a brief exposure to Plasmodium vivax." J Infect Dis 177(4): 1132-1135. Brooks, B. R., R. W. Pastor et al. (1987). "Theoretically determined three-dimensional structure for the repeating tetrapeptide unit of the circumsporozoite coat protein of the malaria parasite Plasmodium falciparum." Proc Natl Acad Sci USA 84: 4470-4474. Brown, A. E., H. K. Webster et al. (1988). "IgM antibody responses to the circumsporozoite protein in naturally acquired falciparum malaria." J Clin Immunol 8(342): 342-348. Brown, A. E., D. Chandanayingyong et al. (1989). "Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA-DR type." Tissue Antigens 34: 200-204. Brown, A. E., H. K. Webster et al. (1991). "Characteristics of natural antibody responses to the circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 44(1): 21-27. Brown, A. E., H. K. Webster et al. (1992). "Characterization of naturally acquired antibodies to the non-repetitive flanking regions of the circumsporozoite protein of Plasmodium falciparum." Am J Trop Med Hyg 47(4): 440-445. Burkot, T. R., P. M. Graves et al. (1989). "Differential antibody responses to Plasmodium falciparum and P vivax circumsporozoite proteins in a human population." J Clin Microbiol 27(1346): 1346- 1351. Burkot, T. R., Z. W. Da et al. (1991). "Fine specificities of monoclonal antibodies against the Plasmodium falciparum circumsporozoite protein: Recognition of both repetitive and non- repetitive regions." Parasite Immunol 13(2): 161-170. Burkot, T. R., R. A. Wirtz et al. (1992). "The population dynamics in mosquitoes and humans of two Plasmodium vivax polymorphs distinguished by different circumsporozoite protein repeat regions." Am J Trop Med Hyg 47(6): 778-786. Burkot, T. R. and P. M. Graves (1995). "The value of vector-based estimates of malaria transmission." Ann Trop Med Parasitol 89(2): 125-134. Büttner, K., C. Pinilla et al. (1992). "Anomalous reversed-phase high-performance liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites." J. Chromatogr. 625(2): 191-198. Callahan, P. M., A. L. Shorter et al. (1991). "The importance of surface charge in the optimization of antigen- adjuvant interactions." Pharmaceut. Res. 8(7): 851-858. Calvo Calle, J. M., E. H. Nardin et al. (1992). "Recognition of different domains of the Plasmodium falciparum CS protein [Igarashi, 1987 #115]by the sera of naturally infected individuals compared with those of sporozoite-immunized volunteers." J Immunol 149(8): 2695-2701. Calvo-Calle, J. M., G. A. de Oliveira et al. (1993). "Immunogenicity of multiple antigen peptides containing B and non- repeat T cell epitopes of the circumsporozoite protein of Plasmodium falciparum." J Immunol 150(4): 1403-1412. Calvo-Calle, J. M., J. Hammer et al. (1997). "Binding of malaria T cell epitopes to DR and DQ molecules in vitro correlates with immunogenicity in vivo - identification of a universal T cell epitope in the Plasmodium falciparum circumsporozoite protein." J Immunol 159(3): 1362-1373. Campbell, G. H., F. H. Collins et al. (1987). "Age-specific prevalence of antibody to a synthetic peptide of the circumsporozoite protein of Plasmodium falciparum in children from three villages in Kenya." Am J Trop Med Hyg 37(220): 220-224. Campbell, G. H., B. A. Brandling et al. (1987). "Detection of antibodies in human sera to the repeating epitope of the circumsporozoite protein of Plasmodium falciparum using the synthetic peptide (NANP)3 in an enzyme-linked immunosorbent assay (ELISA)." Am J Trop Med Hyg 37(17): 17-21. Campbell, G. H., S. B. Aley et al. (1987). "Use of synthetic and recombinant peptides in the study of host-parasite interactions in the malarias." Am J Trop Med Hyg 37: 428-444. Campbell, J. R., F. P. Paleologo et al. (1988). "Immune response of humans to the circumsporozoite protein of Plasmodium falciparum: limited T cell response to the immunodominant central repeat region." Am J Trop Med Hyg 39(232): 232-235. Carvalho, L. H., C. J. F. Fontes et al. (1997). "Cross-reactive cellular immune response to circumsporozoite proteins of Plasmodium vivax and P. falciparum in malaria-exposed individuals." Parasite Immunol 19(2): 47-59. Carvalho, L. H., C. J. E. Fontes et al. (1999). "Cellular responses to Plasmodium falciparum major surface antigens and their relationship to human activities associated with malaria transmission." Am J Trop Med Hyg 60(4): 674-679. Caspers, P., H. Etlinger et al. (1991). "A Plasmodium falciparum malaria vaccine candidate which contains epitopes from the circumsporozoite protein and a blood stage antigen, 5.1." Mol Biochem Parasitol 47(2): 143-50. Cerami, C., F. Kwakye-Berko et al. (1992). "Binding of malarial circumsporozoite protein to sulfatides [Gal(3-SO4)b1-Cer] and cholesterol-3-sulfate and its dependence on disulfide bond formation between cysteines in region II." Mol Biochem Parasitol 54(1): 1-12. Chaba, B., P. Kumar et al. (1998). "Influence of immunoadjuvants and a promiscous T-cell determinant on the immunogenicity of RESA peptide antigen of P. falciparum." Int J Immunopharmacol 20(6): 259-273. Chai, S. K., P. Clavijo et al. (1992). "Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes." J Immunol 149(7): 2385-2390. Charoenvit, Y., W. E. Collins et al. (1991). "Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence." Science 251(4994): 668-671. Charoenvit, Y., S. Mellouk et al. (1991). "Monoclonal, but not polyclonal, antibodies protect against Plasmodium yoelii sporozoites." J Immunol 146(3): 1020-1025. Chatterjee, S., M. Wery et al. (1995). "Conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge." Infect Immun 63(11): 4375-4381. Chatterjee, S., G. François et al. (1996). "Immunity to Plasmodium berghei exoerythrocytic from irradiated sporozoites." Parasitol Res. 82(4): 297-303. Cheng, K.-C., G. L. Smith et al. (1986). Expression of malaria circumsporozoite protein and hepatitis B virus surface antigen by infectious vaccinia virus. Cold Spring Harbor, Cold Spring Harbor Laboratory. Chougnet, C., P. Deloron et al. (1990). "Longitudinal study of the cellular response to Pf155/RESA and circumsporozoite protein in Madagascar." Immunol Lett 25(1-3): 231-236. Chougnet, C., P. Deloron et al. (1990). "Humoral and cell-mediated immune responses to the Plasmodium falciparum antigens Pf155/RESA and CS protein: seasonal variations in a population recently reexposed to endemic malaria." Am J Trop Med Hyg 43: 234-242. Chougnet, C., J. P. Lepers et al. (1991). "Lymphoproliferative responses to synthetic peptides from merozoite ring-infected erythrocyte surface antigen and circumsporozoite protein:." Am J Trop Med Hyg 45(5): 560-566. Chougnet, C., J. P. Lepers et al. (1991). "Lymphoproliferative responses to synthetic peptides from merozoite ring-infected erythrocyte surface antigen and circumsporozoite protein: a longitudinal study during a falciparum malaria episode." Am J Trop Med Hyg 45(5): 560-6. Chougnet, C. (1992). "Specific immune response against epitopes of Pf155/RESA and CSP antigens of P falciparum: immunoepidemiological studies in Madagascar." C R Soc Biol 186(3): 300-303. Clarke, L. E., F. M. Tomley et al. (1990). "Regions of an Eimeria tenella antigen contain sequences which are conserved in circumsporozoite proteins from Plasmodium spp. and which are related to the thrombospondin gene family." Mol Biochem Parasitol 41(2): 269-280. Clough, E. R., F. M. Audibert et al. (1985). "Biologically active antibodies elicited by a synthetic circumsporozoite peptide of Plasmodium knowlesi administered in saline with a muramyl dipeptide derivative." Infect Immun 48(839): 839-842. Cobelens, F. G. J., J.-P. Verhave et al. (1998). "Testing for anti-circumsporozoite and anti-blood-stage antibodies for epidemiologic assessment of Plasmodium falciparum infection in travelers." Am J Trop Med Hyg 58(1): 75-80. Cochrane, A. H., W. E. Collins et al. (1984). "Monoclonal antibody identifies circumsporozoite protein of Plasmodium malariae and detects a common epitope on Plasmodium brasilianum sporozoites." Infect Immun 45(592): 592-595. Cochrane, A. H., C. F. Ockenhouse et al. (1984). "Identification of circumsporozoite proteins in individual malaria-infected mosquitoes by western blot analysis." J Immunol Methods 71: 241- 245. Cochrane, A. H., R. W. Gwadz et al. (1985). "Antigenic diversity of the circumsporozoite proteins in the Plasmodium cynomolgi complex." Mol Biochem Parasitol 14: 111-124. Cochrane, A. H., R. W. Gwadz et al. (1986). "Further studies on the antigenic diversity of the circumsporozoite proteins of the Plasmodium cynomolgi complex." Am J Trop Med Hyg 35: 479-487. Cochrane, A. H., R. W. Gwadz et al. (1988). "Isolation of three distinct parasite populations expressing different circumsporozoite proteins from the Philippine strain of Plasmodium knowlesi." J Clin Microbiol 26(178): 178-181. Cochrane, A. H., S. Uni et al. (1990). "Presence of a circumsporozoite-like protein in micronemes of blood-stage merozoites of malaria parasites." Bull Who 68(181): 181-183. Cochrane, A. H., E. H. Nardin et al. (1990). "Widespread reactivity of human sera with a variant repeat of the circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 43(5): 446-451. Cochrane, A. H. and M. Maracic (1991). "Blood stage-induced Plasmodium brasilianum infection in the squirrel monkey induces antibodies which react with the circumsporozoite protein." Infect Immun 59(3): 1180-1182. Cohen, J. (1997). "A recombinant circumsporozoite protein vaccine against malaria." N Engl J Med 336(24): 1760-1761. Collins, W. E., R. S. Nussenzweig et al. (1989). "Immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 40(455): 455-464. Collins, W. E., R. S. Nussenzweig et al. (1990). "Further studies on the immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 43(6): 576-583. Collins, W. E. (1990). "Testing of Plasmodium vivax CS proteins in Saimiri monkeys." Bull WHO 68(S): 42-46. Collins, W. E., J. S. Sullivan et al. (1997). "Protective immunity induced in squirrel monkeys with a multiple antigen construct against the circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 56(2): 200-210. Colomer, G. V. and V. Enea (1990). "Plasmodium yoelii nigeriensis circumsporozoite gene structure and its implications for the evolution of the repeat regions." Mol Biochem Parasitol 43(1): 51- 58. Colomer-Gould, V. and V. Enea (1990). "Plasmodium yoelii nigeriensis circumsporozoite gene structure and its implications for the evolution of the repeat regions." Mol Biochem Parasitol 43: 51-58. Dame, J. B., J. L. Williams et al. (1984). "Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum." Science 225: 593-599. Daniel-Ribeiro, C. T., J. Oliveira-Ferreira et al. (1992). "Modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection." Mem Inst Oswaldo Cruz 87(Suppl. 5): 117-124. Davis, J. R., J. R. Murphy et al. (1989). "Estimate of anti- Plasmodium falciparum sporozoite activity in humans vaccinated with synthetic circumsporozoite protein (NANP)3." Trans. R. Soc. Trop. Med. Hyg. 83: 748-750. Davis, J. R., J. F. Cortese et al. (1992). "Plasmodium falciparum: in vitro characterization and human infectivity of a cloned line." Exp Parasitol 74(2): 159-168. Davis, J. R., M. S. Beier et al. (1993). "Effects of ingested human anti-sporozoite sera on Plasmodium falciparum sporogony in Anopheles stephensi." Am J Trop Med Hyg 49(2): 174-180. de Groot, A. S., A. H. Johnson et al. (1989). "Human T cell recognition of polymorphic epitopes from malaria circumsporozoite protein." J Immunol 142(4000): 4000-4005. de la Cruz, V. F. and T. F. McCutchan (1986). "Heterogeneity at the 5' end of the circumsporozoite protein gene of Plasmodium falciparum is due to a previously undescribed repeat sequence." Nucleic Acids Res 14(4695): 4695-4695. de la Cruz, V., A. A. Lal et al. (1987). "Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development." J Biol Chem 262: 11935-11939. de la Cruz, V., A. A. Lal et al. (1987). "Evolution of the immunodominant domain of the circumsporozoite protein gene from Plasmodium vivax. Implications for vaccines." J Biol Chem 262: 6464-6467. de la Cruz, V. F., W. L. Maloy et al. (1988). "Lack of cross- reactivity between variant T cell determinants from malaria circumsporozoite protein." J Immunol 141(2456): 2456-2460. de la Cruz, V. F., A. A. Lal et al. (1988). "Variation among circumsporozoite protein genes from rodent malarias." Mol Biochem Parasitol 28: 31-38. de la Cruz, V. F., W. L. Maloy et al. (1989). "The immunologic significance of variation within malaria circumsporozoite protein sequences." J Immunol 142: 3568-3575. Del Giudice, G., J. A. Cooper et al. (1986). "The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-A-b- restricted: possible implications for malaria vaccines." J Immunol 137: 2952-2955. Del Giudice, G., H. D. Engers et al. (1987). "Antibodies to the repetitive epitope of Plasmodium falciparum circumsporozoite protein in a rural Tanzanian community: a longitudinal study of 132 children." Am J Trop Med Hyg 36: 203-212. Del Giudice, G., Q. Cheng et al. (1988). "Immunogenicity of a non- repetitive sequence of Plasmodium falciparum circumsporozoite protein in man and mice." Immunology 63(187): 187-191. Del Giudice, G., C. Tougne et al. (1990). "A multiple antigen peptide from the repetitive sequence of the Plasmodium malariae circumsporozoite protein induces a specific antibody response in mice of various H-2 haplotypes." Eur J Immunol 20(7): 1619-1622. Del Giudice, G., C. Tougne et al. (1991). "Characterization of murine monoclonal antibodies against a repetitive synthetic peptide from the circumsporozoite protein of the human malaria parasite, Plasmodium falciparum." Mol Immunol 28(9): 1003-1009. Del Giudice, G., A. R. Lussow et al. (1991). "Heat shock proteins as 'super'-carriers for sporozoite peptide vaccines." Res. Immunol 142(8): 703-707. del Guercio, M.-F., J. Alexander et al. (1997). "Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T Helper Epitopes (PADRE) for antibody responses in vivo." Vaccine 15: 441-448. del Portillo, H. A., R. S. Nussenzweig et al. (1987). "Circumsporozoite gene of a Plasmodium falciparum strain from Thailand." Mol Biochem Parasitol 24: 289-294. Deloron, P., G. H. Campbell et al. (1989). "Antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen and P. falciparum and P. malariae circumsporozoite proteins: Seasonal prevalence in Kenyan villages." Am J Trop Med Hyg 41: 395-399. Deloron, P. and M. Cot (1990). "Antibodies to the ring-infected erythrocyte surface antigen and the circumsporozoite protein of Plasmodium falciparum in a rural community from Burkina Faso." Trans R Soc Trop Med Hyg 84(2): 191-195. Deloron, P., C. Chougnet et al. (1991). "Protective value of elevated levels of gamma interferon in serum against exoerythrocytic stages of Plasmodium falciparum." J Clin Microbiol 29(9): 1757-1760. Deloron, P. and C. Chougnet (1992). "Is immunity to malaria really short-lived." Parasitol Today 8(11): 375-378. Deodhar, S. S., S. Sampath et al. (1992). "Expression of selected domains of the circumsporozoite antigen of Plasmodium knowlesi." J. Biosci. 17(1): 45-53. Dégano, P., J. Schneider et al. (2000). "Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: enhanced CD8+T cell immunogenicity and protective efficacy in the influenza and malaria models." Vaccine 18(7-8): 623-632. Di Cristina, M., F. Ghouze et al. (1999). "Transformed Toxoplasma gondii tachyzoites expressing the circumsporozoite protein of Plasmodium knowlesi elicit a specific immune response in rhesus monkeys." Infect Immunity 67(4): 1677-1682. di Giovanni, L., A. H. Cochrane et al. (1990). "On the evolutionary history of the circumsporozoite protein in plasmodia." Exp Parasitol 70(4): 373-81. Doherty, J. F., M. Pinder et al. (1999). "A phase I safety and immunogenicity trial with the candidate malaria vaccine RTS,S/SBAS2 in semi-immune adults in the Gambia." Am J Trop Med Hyg 61(6): 865-868. Dontfraid, F., M. A. Cochran et al. (1988). "Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein." Mol Biol Med 5: 185-196. Doolan, D. L., R. A. Houghten et al. (1991). "Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein." Int Immunol 3(6): 511-516. Doolan, D. L., A. J. Saul et al. (1992). "Geographically restricted heterogeneity of the Plasmodium falciparum circumsporozoite protein: relevance for vaccine development." Infect Immun 60(2): 675-82. Doolan, D. L. and M. F. Good (1992). "Plasmodium falciparum CS protein - prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation." Mem Inst Oswaldo Cruz 87(Suppl. 3): 241-247. Doolan, D. L., C. Khamboonruang et al. (1993). "Cytotoxic T lymphocyte (CTL) low-responsiveness to the Plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: analysis of human CTL response to most known variants." Int Immunol 5(1): 37-46. Doolan, D. L., H.-P. Beck et al. (1994). "Evidence for limited activation of distinct CD4+ T-Cells subsets in response to the Plasmodium falciparum circumsporozoite protein in Papua New Guinea." Parasite Immunol 16(3): 129-136. Doolan, D. L., M. Sedegah et al. (1996). "Circumventing genetic restriction of protection against malaria with multigene DNA imunization: CD8+T cell-, interferon g-, and nitric oxide- dependent immunity." J Exp Med 183: 1739-1746. Doolan, D. L., B. Wizel et al. (1996). "Class I HLA-restricted cytotoxic T lymphocyte responses against malaria - Elucidation on the basis of HLA peptide binding motifs." Immunol Res. 15(4): 280- 305. Doolan, D. L., M. Sedegah et al. (1996). "DNA vaccination against malaria." Advan Drug Delivery Rev 21(1): 49-61. Doolan, D. L., R. C. Hedstrom et al. (1997). "DNA vaccines for malaria: the past, the present, & the future." Indian J Med Res 106: 109-119. Doolan, D. L., S. L. Hoffman et al. (1997). "Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles." Immunity 7(1): 97-112. Doolan, D. L. and S. L. Hoffman (1997). "Multi-gene vaccination against malaria: a multistage, multi-immune response approach." Parasitol Today 13(5): 171-178. Duque, S., S. Montenegro-James et al. (1998). "Expression of cytokine genes in Aotus monkeys immunized with synthetic and recombinant Plasmodium vivax and P. falciparum antigens." Ann Trop Med Parasitol 92(5): 553-559. Dyson, H. J., A. C. Satterthwait et al. (1990). "Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by 1H NMR." Biochemistry 29(34): 7828-7837. Egan, J. E., S. L. Hoffman et al. (1993). "Humoral immune responses in volunteers immunized with irradiated Plasmodium falciparum sporozoites." Am J Trop Med Hyg 49(2): 166-173. Eichinger, D. J., D. E. Arnot et al. (1986). "Circumsporozoite protein of Plasmodium berghei: gene cloning and identification of the immunodominant epitopes." Mol Cell Biol 6(3965): 3965-3972. Elliott, S. L., S. Pye et al. (1999). "Peptide based cytotoxic T- cell vaccines; delivery of multiple epitopes, help, memory and problems." Vaccine 17(15-16): 2009-2019. Ellis, J., L. S. Ozaki et al. (1983). "Cloning and expression in E. coli of the malaria sporozoite surface antigen gene from Plasmodium knowlesi." Nature 302: 536-538. Enea, V., D. Arnot et al. (1984). "Circumsporozoite gene of plasmodium cynomolgi (Gombak):cDNA cloning and expression of the repetitive circumsporozoite epitope." Proc Natl Acad Sci USA 81: 7520-7524. Enea, V., J. Ellis et al. (1984). "DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope." Science 225: 628-630. Enea, V. (1985). "The circumsporozoite antigen: the gene and the antigen." Ann Ist Super Sanita 21(291): 291-298. Enea, V., M. Galinski et al. (1986). "Evolutionary profile of the circumsporozoite gene of the Plasmodium cynomolgi complex." J Mol Biol 188(721): 721-726. Enea, V. and D. Arnot (1988). The circumsporozoite gene in Plasmodia. ? Escalante, A. A., E. Barrio et al. (1995). "Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene." Mol Biol. Evol. 12(4): 616-626. Esposito, F., S. Lombardi et al. (1988). "Prevalence and levels of antibodies to the circumsporozoite protein of Plasmodium falciparum in an endemic area and their relationship to resistance against malaria infection." Trans Roy Soc Trop Med Hyg 82: 827- 832. Esposito, G., A. Pessi et al. (1989). "1H-NMR studies of synthetic polypeptide models of Plasmodium falciparum circumsporozoite protein tandemly repeated sequence." Biopolymers 28(225): 225-246. Esposito, F., A. M. Santroni et al. (1990). "Intraerythrocytic administration of a synthetic Plasmodium antigen elicits antibody response in mice, without carrier molecules or adjuvants." Int J. Parasitol 20(8): 1109-1111. Esposito, F., S. Lombardi et al. (1992). "In vitro immune recognition of synthetic peptides from the Plasmodium falciparum CS protein by individuals naturally exposed to different sporozoite challenge." Immunol Lett. 33(2): 187-200. Etlinger, H. M., L. Renia et al. (1991). "Antibody responses to a synthetic peptide-based malaria vaccine candidate: influence of sequence variants of the peptide." Eur J Immunol 21(6): 1505-1511. Etlinger, H. M. and R. Knorr (1991). "Model using a peptide with carrier function for vaccination against different pathogens." Vaccine 9(7): 512-514. Etlinger, H. M. and A. Trzeciak (1993). "Towards a synthetic malaria vaccine: cyclization of a peptide eliminates the production of parasite-unreactive antibody." Phil. Trans. Roy. Soc. London [Biol] 340(1291): 69-72. Fasel, N., R. C. Begdadi et al. (1992). "Dictyostelium discoideum as an expression host for the circumsporozoite protein of Plasmodium falciparum." Gene 111(2): 157-63. Fern, J. and M. F. Good (1992). "Promiscuous malaria peptide epitope stimulates CD45Ra T cells from peripheral blood of nonexposed donors." J Immunol 148(3): 907-913. Ferreira-da-Cruz, M. F., D. C. Deslandes et al. (1995). "Antibody responses to Plasmodium falciparum sporozoite-, liver- and blood- stage synthetic peptides in migrant and autochthonous populations in malaria endemic areas." Parasite 2: 23-29. Folena, W. G., R. Inacker et al. (1987). "Assay, purification and characterization of a recombinant malaria circumsporozoite fusion protein by high-performance liquid chromatography." J Chromatogr 411(345): 345-354. Fontes, C. C. J., I. Bathurst et al. (1991). "Plasmodium vivax sporozoite antibodies in individuals exposed during a single malaria outbreak in a non-endemic area." Am J Trop Med Hyg 44(1): 28-33. Franke, E. D., C. M. Lucas et al. (1991). "Antibody response of humans to the circumsporozoite protein of Plasmodium vivax." Infect Immun 59(8): 2836-2838. Franke, E. D., C. M. Lucas et al. (1992). "Antibody response to the circumsporozoite protein of Plasmodium vivax in naturally infected humans." Am J Trop Med Hyg 46(3): 320-6. Franke, E. D., C. M. Lucas et al. (1992). "Prevalence of antibody to the variant repeat of the circumsporozoite protein of Plasmodium vivax in Peru." Am J Trop Med Hyg 46(6): 708-710. Franke, E. D., G. Corradin et al. (1997). "Induction of protective CTL responses against the Plasmodium yoelii circumsporozoite protein by immunization with peptides." J Immunol 159(7): 3424- 3433. Franke, E. D., S. L. Hoffman et al. (1999). "Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoelii sporozoites." Vaccine 17(9- 10): 1201-1205. Frevert, U., P. Sinnis et al. (1993). "Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes." J Exp Med 177(5): 1287-1298. Frevert, U. (1994). "Malaria sporozoite-hepatocyte interactions." Exp Parasitol 79(2): 206-210. Frevert, U., P. Sinnis et al. (1996). "Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro." Mol Biochem Parasitol 76(1-2): 257- 266. Frevert, U. (1999). "Heparan sulphate and RNA-binding motifs in the malaria circumsporozoite protein." Biochem Soc Trans 27(4): 482-487. Fries, L. F., D. M. Gordon et al. (1992). "Safety, immunogenicity, and efficacy of a Plasmodium falciparum vaccine comprising a circumsporozoite protein repeat region peptide conjugated to Pseudomonas aeruginosa toxin A." Infect Immun 60(5): 1834-9. Galinski, M. R., D. E. Arnot et al. (1987). "The circumsporozoite gene of the Plasmodium cynomolgi complex." Cell 48: 311-319. Gantt, S. M., P. Clavijo et al. (1997). "Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG." J Biol Chem 272(31): 19205-19213. George, F. t., J. L. Law et al. (1990). "Identification of a T- cell epitope on the circumsporozoite protein of Plasmodium vivax." Infect Immun 58(2): 575-8. Gerloni, M., S. D. Xiong et al. (1998). "Durable immunity and immunologic memory to a parasite antigen induced by somatic transgene immunization." Vaccine 16(2-3): 293-297. Gibson, K. D. and H. A. Scheraga (1986). "Predicted conformations for the immunodominant region of the circumsporozoite protein of the human malaria parasite Plasmodium falciparum." Proc Natl Acad Sci USA 83: 5649-5653. Gilbert, S. C., M. Plebanski et al. (1997). "A protein particle vaccine containing multiple malaria epitopes." Nature Biotechnol. 15(11): 1280-1284. Gilbert, S. C., M. Plebanski et al. (1998). "Association of malaria parasite population structure, HLA, and immunological antagonism." Science 279(5354): 1173-1177. Godson, G. N., J. Ellis et al. (1983). "Identification and chemical synthesis of a tandemly repeated immunogenic region of Plasmodium knowlesi circumsporozoite protein." Nature 305: 29-36. Goldman, I. F., S. H. Qari et al. (1993). "Circumsporozoite protein gene of Plasmodium simium, a Plasmodium vivax-like monkey malaria parasite." Mol Biochem Parasitol 57(1): 177-180. Golenda, C. F., R. Burge et al. (1992). "Plasmodium falciparum and P. berghei - detection of sporozoites and the circumsporozoite proteins in the saliva of Anopheles stephensi mosquitoes." Parasitol Res. 78(7): 563-569. Gonzalez, C., D. Hone et al. (1994). "Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans." J Infect Dis 169(4): 927-931. Gonzalez-Ceron, L., M. H. Rodriguez et al. (1998). "Plasmodium vivax: A monoclonal antibody recognizes a circumsporozoite protein precursor on the sporozoite surface." Exp Parasitol 90(3): 203- 211. Good, M. F., J. A. Berzofsky et al. (1986). "Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine." J Exp Med 164: 655-660. Good, M. F., W. L. Maloy et al. (1987). "Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein." Science 235: 1059-1062. Good, M. F., D. Pombo et al. (1988). "Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule." Proc Natl Acad Sci USA 85: 1199-1203. Good, M. F., J. A. Berzofsky et al. (1988). "The T cell response to the malaria circumsporozoite protein: an immunological approach to vaccine development." Ann Rev Immunol 6: 663-688. Good, M. F., D. Pombo et al. (1988). "Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein." J Immunol 140: 1645-1650. Good, M. F., L. H. Miller et al. (1988). "Limited immunological recognition of critical malaria vaccine candidate antigens." Science 242: 574-577. Good, M. F., S. Kumar et al. (1989). "T-cell antigenic sites of the malaria circumsporozoite protein." Am Soc Hematol 74(3): 895- 900. Good, M. F. and Y. Zevering (1990). "Peptide analysis of the T cell response to the malaria circumsporozoite (CS) protein." Immunol Lett 25(1-3): 49-52. Good, M. F. and J. Currier (1992). "The importance of T cell homing and the spleen in reaching a balance between malaria immunity and immunopathology: The moulding of immunity by early exposure to cross-reactive organisms." Immunol Cell Biol. 70(Part 6): 405-410. Good, M. F., Y. Zevering et al. (1993). "Original antigenic sin, T cell memory, and malaria sporozoite immunity: an hypothesis for immune evasion." Parasite Immunol 15(4): 187-193. Good, M. F. and J. Bilsborough (1994). "Human T-cell responses to malaria: mostly forgotten or committed to memory?" Parasitol Today 10(8): 316-319. Good, M. F. (1995). "Harnessing cytotoxic T lymphocytes for vaccine design." Lancet 345(8956): 999-1000. Gordon, D. M., D. R. Davis et al. (1991). "Significance of circumsporozoite-specific antibody in the natural transmission of Plasmodium falciparum, Plasmodium vivax, and Plasmodium malariae in an Aboriginal (Orang Asli) population of central peninsular Malaysia." Am J Trop Med Hyg 45(1): 49-56. Gordon, D. M. (1993). "Use of novel adjuvants and delivery systems to improve the humoral and cellular immune response to malaria vaccine candidate antigens." Vaccine 11(5): 591-593. Gordon, D. M., T. W. McGovern et al. (1995). "Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine." J Infect Dis 171(6): 1576-1585. Goundis, D. and K. B. Reid (1988). "Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs." Nature 335: 82-85. Gramzinski, R. A., D. C. Maris et al. (1996). "Optimization of antibody responses of a malaria DNA vaccine in Aotus monkeys." Vaccine Res. 5: 173-183. Gramzinski, R. A., D. C. Maris et al. (1997). "Malaria DNA vaccines in Aotus monkeys." Vaccine 15(8): 913-915. Greenwood, J., A. E. Willis et al. (1991). "Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigens." J. Mol Biol. 220(4): 821-827. Grifantini, R., O. Finco et al. (1998). "Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid." Eur J Immunol 28(4): 1225-1232. Grillot, D., M. Michel et al. (1990). "Immune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii." Eur J Immunol 20(6): 1215-1222. Grillot, D., A. Pessi et al. (1990). "Reduced antibody response to the repetitive sequence of the Plasmodium falciparum circumsporozoite protein in mice infected with Plasmodium yoelii blood forms." Med. Microbiol. Immunol 179(5): 237-244. Grillot, D., D. Valmori et al. (1993). "Presentation of T-cell epitopes assembled as multiple-antigen peptides to murine and human T lymphocytes." Infect Immun 61(7): 3064-3067. Guttinger, M., P. Caspers et al. (1988). "Human T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein." EMBO J 7: 2555-2558. Haddad, D., S. Liljeqvist et al. (1999). "Characterization of antibody responses to a Plasmodium falciparum blood-stage antigen induced by a DNA prime protein boost immunization protocol." Scand. J Immunol 49(5): 506-514. Haeseleer, F., J.-F. Pollet et al. (1993). Stable integration and expression of Plasmodium falciparum antigen coding sequences in Mycobacteria. Vaccines 93. H. S. Ginsberg, F. Brown, R. M. Chanock and R. A. Lerner. Cold Spring Harbor, Cold Spring Harbor Lab. Press: 413-417. Hamilton, A. J., A. Suhrbier et al. (1988). "Immunoelectron microscopic localization of circumsporozoite antigen in the differentiating exoerythrocytic trophozoite of Plasmodium berghei." Cell Biol Int Rep 12: 123-129. Hamilton, A. J., C. S. Davies et al. (1988). "Expression of circumsporozoite proteins revealed in situ in the mosquito stages of Plasmodium berghei by the Lowicryl-immunogold technique." Parasitology 96: 273-280. Hanke, T., J. Schneider et al. (1998). "DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice." Vaccine 16(4): 426-435. Hanke, T., V. C. Neumann et al. (1999). "Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime." Vaccine 17(6): 589-596. Hedstrom, R. C., J. R. Campbell et al. (1990). "A malaria sporozoite surface antigen distinct from the circumsporozoite protein." Bull Who 68: 152-157. Hedstrom, R. C., D. L. Doolan et al. (1997). "The development of a multivalent DNA vaccine for malaria." Springer Sem Immunopathol 19(2): 147-159. Hedstrom, R. C., D. L. Doolan et al. (1998). "In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre- erythrocytic stage DNA vaccines." Int J. Mol Med. 2(1): 29-38. Herrera, S., P. Escobar et al. (1992). "Human Recognition of T- Cell Epitopes on the Plasmodium-Vivax Circumsporozoite Protein." Journal of Immunology 148(12): 3986-3990. Herrera, M. A., C. de Plata et al. (1994). "Immunogenicity of multiple antigen peptides containing Plasmodium vivax CS epitopes in BALB/c mice." Mem Inst Oswaldo Cruz 89(Suppl. 2): 71-76. Herrera, S., C. De Plata et al. (1997). "Antigenicity and immunogenicity of multiple antigen peptides (MAP) containing P. vivax CS epitopes in Aotus monkeys." Parasite Immunol 19(4): 161- 170. Herrington, D. A., D. F. Clyde et al. (1987). "Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites." Nature (London) 328: 257-259. Herrington, D. A., E. H. Nardin et al. (1991). "Safety and immunogenicity of a recombinant sporozoite malaria vaccine against Plasmodium vivax." Am J Trop Med Hyg 45(6): 695-701. Herrington, D., J. Davis et al. (1991). "Successful immunization of humans with irradiated malaria sporozoites: Humoral and cellular responses of the protected individuals." Am J Trop Med Hyg 45(5): 539-547. Herrington, D. A., G. A. Losonsky et al. (1992). "Safety and immunogenicity in volunteers of a recombinant Plasmodium falciparum circumsporozoite protein malaria vaccine produced in Lepidopteran cells." Vaccine 10(12): 841-846. Hoffman, S. L., R. J. Wistar et al. (1986). "Immunity to malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum." N Engl J Med 315(601): 601-606. Hoffman, S. L., J. A. Berzofsky et al. (1989). "Immune response gene regulation of immunity to Plasmodium berghei sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines." J Immunol 142: 3581- 3584. Hoffman, S. L., V. Nussenzweig et al. (1991). "Progress toward malaria preerythrocytic vaccines." Science 252(5005): 520-521. Hoffman, S. L., M. Sedegah et al. (1994). "Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine." Vaccine 12(16): 1529-1533. Hoffman, S. L., R. Edelman et al. (1994). "Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant." Am J Trop Med Hyg 51(5): 603-612. Hoffman, S. L., D. L. Doolan et al. (1997). "Toward clinical trials of DNA vaccines against malaria." Immunol Cell Biol. 75(4): 376-381. Hoffman, S. L., D. L. Doolan et al. (1997). "Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA Hollingdale, M. R., W. R. Ballou et al. (1987). "Plasmodium falciparum: elicitation by peptides and recombinant circumsporozoite proteins of circulating mouse antibodies inhibiting sporozoite invasion of hepatoma cells." Exp Parasitol 63(345): 345-351. Hollingdale, M. R., A. Appiah et al. (1990). "Activity of human volunteer sera to candidate Plasmodium falciparum circumsporozoite protein vaccines in the inhibition of sporozoite invasion assay of human hepatoma cells and hepatocytes." Trans.R.Soc.Trop.Med.Hyg. 84(3): 325-329. Hollingdale, M. R., M. Aikawa et al. (1990). "Pre-erythrocytic stage malaria parasites: Non-circumsporozoite protein antigens." Bull Who 68(178): 178-180. Hollingdale, M. R., R. E. Sinden et al. (1993). "Sporozoite invasion." Nature 362(6415): 26. Hope, I. A., R. Hall et al. (1984). "Evidence for immunological cross-reaction between sporozoites and blood stages of a human malaria parasite." Nature (London) 308: 191-194. Hosmalin, A., S. Kumar et al. (1992). "Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1." J Immunol 149(4): 1311-1318. Hughes, A. L. (1991). "Circumsporozoite protein genes of malaria parasites (Plasmodium spp.):." Genetics 127(2): 345-353. Hughes, A. L. and F. Verra (1998). "Ancient polymorphism and the hypothesis of a recent bottleneck in the malaria parasite Plasmodium falciparum." Genetics 150(1): 511-513. Hügel, F.-U., G. Pradel et al. (1996). "Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes." Mol Biochem Parasitol 81(2): 151-170. Ichino, M., G. Mor et al. (1999). "Factors associated with the development of neonatal tolerance after the administration of a plasmid DNA vaccine." J Immunol 162(7): 3814-3818. Ishii, K. J., W. R. Weiss et al. (1999). "Activity and safety of DNA plasmids encoding IL-4 and IFN gamma." Gene Therapy 6(2): 237- 244. Ivanov, B. B., E. A. Meshcheryakova et al. (1991). "Synthetic carriers and adjuvants increase immunogenicity of the synthetic peptide, B-epitope from CS-protein of Plasmodium falciparum." Bioorg. Khim. 17(6): 732-746. Ivanov, B. B., V. V. Yurovsky et al. (1991). "Peptides from Plasmodium falciparum proteins: Synthesis and conjugation to proteins and synthetic carriers." Bioorg. Khim. 17(4): 486-493. Ivanov, B. B., E. A. Meshcheryakova et al. (1994). "Dituftsin and polytuftsin induce an anti-peptide IgG response to non-immunogenic peptides in mice." Immunol Invest. 23(3): 201-212. Jacobs, P., M. Massaer et al. (1991). " Plasmodium falciparum: recombinant baculoviruses direct the expression of circumsporozoite proteins in Spodoptera frugiperda cell cultures." Mol Biol Rep 15(2): 73-9. Jalil, M. K. and R. D. Nageswara (1991). "Antibodies to Plasmodium falciparum ring infected erythrocyte surface antigen and P. falciparum and P. vivax circumsporozoite proteins." Med Sci Res 19(11): 345-349. Jaulin, C., J. L. Casanova et al. (1992). "Highly diverse T cell recognition of a single Plasmodium berghei peptide presented by a series of mutant H-2Kd molecules." J Immunol 149(12): 3990-3994. Jelinek, T., H. D. Nothdurft et al. (1995). "Evaluation of circumsporozoite antibody testing as a sero-epidemiological tool for the detection of Plasmodium falciparum infection in non-immune travelers." Trop. Med. Parasitol 46(3): 154-157. Jelinek, T., T. Löscher et al. (1996). "High prevalence of antibodies against circumsporozoite antigen of Plasmodium falciparum without development of symptomatic malaria in travelers returning from sub-Saharan Africa." J Infect Dis 174(6): 1376- 1379. Jelinek, T., A. Blüml et al. (1998). "Assessing the incidence of infection with Plasmodium falciparum among international travelers." Am J Trop Med Hyg 59(1): 35-37. Jolivet, M., L. Lise et al. (1990). "Polyvalent synthetic vaccines: relationship between T epitopes and immunogenicity." Vaccine 8: 35-40. Jones, T. R., L. F. Yuan et al. (1992). "Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody." Am J Trop Med Hyg 47(6): 837-843. Jones, T. R., N. Obaldia et al. (1999). "Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys." Vaccine 17(23-24): 3065-3071. Jongwutiwes, S., K. Tanabe et al. (1994). "Allelic variation in the circumsporozoite protein of Plasmodium falciparum from Thai field isolates." Am J Trop Med Hyg 51(5): 659-668. Kain, K. C., J. Keystone et al. (1991). "Global distribution of a variant of the circumsporozoite gene of Plasmodium vivax." J Infect Dis 164(1): 208-210. Kain, K. C., R. A. Wirtz et al. (1992). "Serologic and genetic characterization of Plasmodium vivax from whole blood-impregnated filter paper discs." Am J Trop Med Hyg 46(4): 473-479. Kain, K. C., A. E. Brown et al. (1992). "Circumsporozoite genotyping of global isolates of Plasmodium vivax from dried blood specimens." J Clin Microbiol 30(7): 1863-1866. Kalish, M. L., I. J. Check et al. (1991). "Murine IgG isotype responses to the Plasmodium cynomolgi circumsporozoite peptide (NAGG)5. I. Effects of carrier, copolymer adjuvants, and lipopolysacchar ide on isotype selection." J Immunol 146(10): 3583-3590. Kaur, P., P. Sharma et al. (1990). "Synthetic, immunological and structural studies on repeat unit peptides of Plasmodium falciparum antigens." Int J. Pept. Protein Res 36(6): 515-521. Khan, Z. M., C. Ng et al. (1992). "Early hepatic stages of Plasmodium berghei: release of circumsporozoite protein and host cellular inflammatory response." Infect Immun 60(1): 264-70. Khusmith, S., Y. Charoenvit et al. (1991). "Protection against malaria by vaccination with sporozoite surface protein-2 plus CS protein." Science 252(5006): 715-718. Kilgus, J., T. Jardetzky et al. (1991). "Analysis of the permissive association of a malaria T cell epitope with DR molecules." J Immunol 146(1): 307-315. Kilombero, M. P. (1992). "The level of anti-sporozoite antibodies in a highly endemic malaria area and its relationship with exposure to mosquitoes." Trans R Soc Trop Med Hyg 86(5): 499-504. Kironde, F., K. Rao et al. (1991). "Towards the design of heterovalent anti-malaria vaccines: A hybrid immunogen capable of eliciting immune responses to epitopes of circumsporozoite antigens from two different species of the malaria parasite, Plasmodium." Immunology 74(2): 323-328. Kironde, F. A., K. V. Rao et al. (1991). "Towards the design of heterovalent anti-malaria vaccines: a hybrid immunogen capable of eliciting immune responses to epitopes of circumsporozoite antigens from two different species of the malaria parasite, Plasmodium." Immunology 74(2): 323-8. Kitua, A. Y., H. Urassa et al. (1999). "Antibodies against Plasmodium falciparum vaccine candidates in infants in an area of intense and perennial transmission: relationships with clinical malaria and with entomological inoculation rates." Parasite Immunol 21(6): 307-317. Klinman, D. M., J. Conover et al. (1998). "Immunogenicity and efficacy of a DNA vaccine in aged mice." J. Gerontol. -Biol. Sci. 53(4): B281-B286. Kobayashi, S., M. F. Eden et al. (1986). "Partial amino acid sequence of human thrombospondin as determined by analysis of cDNA clones: homology to malarial circumsporozoite proteins." Biochemistry 25: 8418-8425. Kremsner, P. G., S. Neifer et al. (1992). "Prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites, including a variant of Plasmodium vivax, in the population of two epidemiologically distinct areas in the state of Acre, Brazil." Trans R Soc Trop Med Hyg 86(1): 23-7. Krettli, A. U., E. M. Rocha et al. (1988). "Circumsporozoite protein of Plasmodium gallinaceum characterized by monoclonal antibodies." Parasite Immunol 10: 523-533. Krzych, U., K. White et al. (1990). "Role of circumsporozoite protein-specific T-cells in protective immunity against Plasmodium berghei." Bull Who 68(88): 88-93. Krzych, U., T. Jareed et al. (1992). "Distinct T cell specificities are induced with the authentic versus recombinant Plasmodium berghei circumsporozoite protein." J Immunol 148(8): 2530-8. Krzych, U., J. A. Lyon et al. (1995). "T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens." J Immunol 155(8): 4072-4077. Kumar, S., L. H. Miller et al. (1988). "Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum." Nature 334(258): 258-260. Kumar, P., S. Biswas et al. (1999). "Potentiation of immune response against the RESA peptides of Plasmodium falciparum by incorporating a universal T-cell epitope (CS-T3) and an immunomodulator (Polytuftsin), and delivery through liposomes." Microbiol. Immunol 43(6): 567-576. Kumar, P. and D. N. Rao (1999). "Correlation of T-cell response and lymphokine profile with RESA peptides of Plasmodium falciparum containing a universal T-cell epitope and an immunopotentiator, polytuftsin." Microbiol. Immunol 43(6): 561-566. Lal, A. A., l. C. V. de et al. (1987). "Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines." J Biol Chem 262: 2937-2940. Lal, A. A., l. C. V. de et al. (1988). "Structure of the circumsporozoite gene of Plasmodium malariae." Mol Biochem Parasitol 30(291): 291-294. Lal, A. A., l. C. V. de et al. (1988). "Circumsporozoite protein gene from Plasmodium brasilianum. Animal reservoirs for human malaria parasites." J Biol Chem 263(5495): 5495-5498. Lal, A. A., V. F. de la Cruz et al. (1988). "Structure of the circumsporozoite gene of Plasmodium malariae." Mol Biochem Parasitol 30: 291-294. Lal, A. A. and I. F. Goldman (1991). "Circumsporozoite protein gene from Plasmodium reichenowi, a chimpanzee malaria parasite evolutionarily related to the human malaria parasite Plasmodium falciparum." J Biol Chem 266(11): 6686-6689. Lalvani, A., N. Hurt et al. (1996). "Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania." Eur J Immunol 26(4): 773-779. Lalvani, A., P. Moris et al. (1999). "Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine." J Infect Dis 180(5): 1656-1664. Lambros, T., P. Lema et al. (1993). "Capillary electrophoresis of multiple antigenic-peptide (MAPs) of the malaria circumsporozoite protein epitopes." J. Liq. Chromatogr. 16(9-10): 2039-2048. Lanar, D. E. (1990). "Sequence of the circumsporozoite gene of Plasmodium berghei ANKA clone and NK65 strain." Mol Biochem Parasitol 39(1): 151-3. Le, T. P., L. W. P. Church et al. (1998). "Immunogenicity of Plasmodium falciparum circumsporozoite protein multiple antigen peptide vaccine formulated with different adjuvants." Vaccine 16(2-3): 305-312. Leitner, W. W., M. C. Seguin et al. (1997). "Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites." J Immunol 159(12): 6112-6119. Levitt, A., F. O. Dimayuga et al. (1993). "Analysis of malarial transcripts using cDNA-Directed polymerase chain reaction." J. Parasitol 79(5): 653-663. Li, S. Q., M. Rodrigues et al. (1993). "Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria." Proc Natl Acad Sci USA 90(11): 5214-5218. Link, H. T., K. White et al. (1993). "Plasmodium berghei-specific T cells respond to non-processed sporozoites presented by B cells." Eur J Immunol 23(9): 2263-2269. Lockyer, M. J. and R. T. Schwarz (1987). "Strain variation in the circumsporozoite protein gene of Plasmodium falciparum." Mol Biochem Parasitol 22: 101-108. Lockyer, M. J. (1988). "The 5' coding region of the Plasmodium falciparum circumsporozoite protein gene is a focus for deletion and insertion events." Nuc Acids Res 16(18): 9041. Lockyer, M. J., K. Marsh et al. (1989). "Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein." Mol Biochem Parasitol 37(2): 275-80. Lockyer, M. J., C. S. Davies et al. (1990). "Nucleotide sequence of the Plasmodium berghei circumsporozoite protein gene from the ANKA clone 2.34L." Nucleic Acids Res 18(2). Lockyer, M. J. (1991). "Clonal variation in the Plasmodium falciparum circumsporozoite protein gene." Mol Biochem Parasitol 45(1): 179-182. Lombardi, S., F. Esposito et al. (1987). "Detection and anatomical localization of Plasmodium falciparum circumsporozoite protein and sporozoites in the afrotropical malaria vector Anopheles gambiae s.l." Am J Trop Med Hyg 37: 491-494. Lopez, J. A., M. A. Roggero et al. (1996). "Recognition of synthetic 104-mer and 102-mer peptides corresponding to N- and C- terminal nonrepeat regions of the Plasmodium falciparum circumsporozoite protein by sera from human donors." Am J Trop Med Hyg 55(4): 424-429. López, J. A., J. M. González et al. (1997). "Synthetic polypeptides corresponding to the non-repeat regions from the circumsporozoite protein of Plasmodium falciparum: recognition by human T-cells and immunogenicity in owl monkeys." Ann Trop Med Parasitol 91(3): 253-265. Lussow, A. R., G. Del Giudice et al. (1990). "Use of a tuberculin purified protein derivative-Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants." Proc Nat Acad Sci USA 87: 2960-2964. Lussow, A. R., C. Barrios et al. (1991). "Mycobacterial heat-shock proteins as carrier molecules." Eur J Immunol 21(10): 2297-2302. Luty, A. J. F., B. Lell et al. (1999). "Interferon-g responses are associated with resistance to reinfection with Plasmodium falciparum in young African children." J Infect Dis 179(4): 980- 988. Maheswary, N. P., B. Perpanich et al. (1992). "Presence of antibody to a heterologous circumsporozoite protein of." Trans R Soc Trop Med Hyg 86(1). Malik, A., J. E. Egan et al. (1991). "Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein." Proc Natl Acad Sci Usa 88(8): 3300-3304. Malik, A., M. Gross et al. (1993). "Induction of cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein by immunization with soluble recombinant protein without adjuvant." Infect Immun 61(12): 5062-5066. Malik, A., R. Houghten et al. (1995). "Identification of a nonameric H-2Kk-restricted CD8+ cytotoxic T lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein." Infect Immun 63(5): 1955-1959. Mann, V. H., T. Y. Huang et al. (1994). "Sequence variation in the circumsporozoite protein gene of Plasmodium vivax appears to be regionally biased." Mol Biochem Parasitol 68(1): 45-52. Mann, V. H., M. F. Good et al. (1995). "Diversity in the circumsporozoite protein of Plasmodium vivax: does it matter?" Parasitol Today 11(1): 33-36. Manzar, K. J. and D. N. Rao (1990). "Antibodies to P. falciparum ring-infected erythrocyte surface antigen and P. falciparum and P. vivax CS proteins." Med. Sci. Res. 19: 345. Martin, T., S. E. Parker et al. (1999). "Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection." Hum. Gene Ther. 10(5): 759-768. Marussig, M., L. Rénia et al. (1997). "Linear and multiple antigen peptides containing defined T and B epitopes of the Plasmodium yoelii circumsporozoite protein: antibody-mediated protection and boosting by sporozoite infection." Int Immunol 9(12): 1817-1824. Matsumoto, S., T. Yanagi et al. (1996). "Stable expression and secretion of the B-cell epitope of rodent malaria from Mycobacterium bovis BCG and induction of long-lasting humoral response in mouse." Vaccine 14(1): 54-60. Mazier, D. (1991). "Malaria antigens expressed on the surface of infected hepatocytes: a role in protective immunity?" Res. Immunol 142(8): 658-662. McCutchan, T. F., V. F. de la Cruz et al. (1988). "Antigenic diversity in Plasmodium falciparum." Prog. Allergy 41: 173-192. McCutchan, T. F., M. F. Good et al. (1989). "Polymorphism in the circumsporozoite (CS) protein of Plasmodium falciparum." Parasitol Today 5: 143-146. McCutchan, T. F., A. A. Lal et al. (1992). "Two types of sequence polymorphism in the circumsporozoite gene of Plasmodium falciparum." Mol Biochem Parasitol 50(1): 37-45. McCutchan, T. F., J. C. Kissinger et al. (1996). "Comparison of circumsporozoite proteins from avian and mammalian malarias: biological and phylogenetic implications." Proc Natl Acad Sci USA 93(21): 11889-11894. Meis, J. F., H. Croes et al. (1992). "Localization of circumsporozoite protein in the sporogonic stages of Plasmodium vivax." Parasitol Res 78(2): 165-7. Men, Y., B. Gander et al. (1996). "Induction of sustained and elevated immune responses to weakly immunogenic synthetic malarial peptides by encapsulation in biodegradable polymer microspheres." Vaccine 14(15): 1442-1450. Men, Y., R. Audran et al. (1999). "MHC class I- and class II- restricted processing and presentation of microencapsulated antigens." Vaccine 17(9-10): 1047-1056. Mendis, C., G. G. Del et al. (1992). "Anti-circumsporozoite protein antibodies measure age related exposure to malaria in Kataragama, Sri Lanka." Parasite Immunol 14(1): 75-86. Metzger, W. G., C. A. Maxwell et al. (1998). "Anti-sporozoite immunity and impregnated bednets in Tanzanian villages." Ann Trop Med Parasitol 92(6): 727-729. Ménard, R., A. A. Sultan et al. (1997). "Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes." Nature 385(6614): 336-340. Migliorini, P., N. Boulanger et al. (1990). "Plasmodium berghei subunit vaccine: repeat synthetic peptide of circumsporozoite protein comprising T- and B-cell epitopes fails to confer immunity." Scand J Immunol 31(2): 237-42. Migliorini, P., B. Betschart et al. (1993). "Malaria vaccine: immunization of mice with a synthetic T cell helper epitope alone leads to protective immunity." Eur J Immunol 23(2): 582-585. Migot, F., P. Millet et al. (1993). "Humoral and cellular immune responses to the circumsporozoite protein of Plasmodium vivax in Madagascar." Am J Trop Med Hyg 48(4): 524-529. Millet, P., W. E. Collins et al. (1991). "Inhibitory activity against Plasmodium vivax sporozoites induced by plasma from Saimiri monkeys immunized with circumsporozoite recombinant proteins or irradiated sporozoites." Am J Trop Med Hyg 45(1): 44- 48. Millet, P., M. L. Kalish et al. (1992). "Effect of adjuvant formulations on the selection of B-cell epitopes expressed by a malaria peptide vaccine." Vaccine 10(8): 547-550. Millet, P., K. K. Grady et al. (1995). "Use of the rhesus monkey as an experimental model to test the degree of efficacy of an anti-sporozoite peptide malaria vaccine candidate combined with polymer-based adjuvants." Am J Trop Med Hyg 52(4): 328-335. Miyahira, Y., K. Murata et al. (1995). "Quantification of antigen specific CD8+ T cells using an ELISPOT assay." J Immunol Methods 181(1): 45-54. Miyahira, Y., A. García-Sastre et al. (1998). "Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8+ responses in mice." Proc Natl Acad Sci USA 95(7): 3954-3959. Modiano, D., V. Petrarca et al. (1996). "Different response to Plasmodium falciparum malaria in West African sympatric ethnic groups." Proc Natl Acad Sci USA 93(23): 13206-13211. Modiano, D., V. Petrarca et al. (1999). "Different response to Plasmodium falciparum in West African sympatric ethnic groups: possible implications for malaria control strategies." Parassitologia 41: 193-197. Modiano, D., A. Chiucchiuini et al. (1999). "Interethnic differences in the humoral response to non-repetitive regions of the Plasmodium falciparum circumsporozoite protein." Am J Trop Med Hyg 61(4): 663-667. Moreno, A., P. Clavijo et al. (1991). "Cytotoxic CD4+ T cells from a sporozoite-immunized volunteer recognize the Plasmodium falciparum CS protein." Int Immunol 3(10): 997-1003. Moreno, A., P. Clavijo et al. (1993). "CD4+ T-cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein." J Immunol 151(1): 489-499. Mota, J., O. Coreńo et al. (1996). "Prevalence of antibodies to the repeat epitope of the circumsporozoite protein of Plasmodium vivax in San Luis Potosi, Mexico." Arch Med Res 27(2): 233-236. Munesinghe, D. Y., P. Clavijo et al. (1991). "Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein." Eur J Immunol 21(12): 3015-3020. Munesinghe, D. Y., P. Clavijo et al. (1991). "Immunogenicity of multiple antigen peptides (MAP) containing T and B cell epitopes of the repeat region of the P. falciparum circumsporozoite protein." Eur J Immunol 21(12): 3015-20. Mvondo, J. L., M. A. James et al. (1992). "Malaria and pregnancy in Cameroonian women. Naturally acquired antibody responses to asexual blood-stage antigens and the circumsporozoite protein of Plasmodium falciparum." Trans Roy Soc Trop Med Hyg 86(5): 486-490. Nagata, T., M. Uchijima et al. (1999). "Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: Analysis of plasmid DNA encoding a CTL epitope derived from microorganisms." Biochem Biophys Res Commun 261(2): 445-451. Naitza, S., F. Spano et al. (1998). "The thrombospondin-related protein family of apicomplexan parasites: The gears of the cell invasion machinery." Parasitol Today 14(12): 479-484. Nanzer, A. P., A. E. Torda et al. (1997). "Dynamical studies of peptide motifs in the Plasmodium falciparum circumsporozoite surface protein by restrained and unrestrained MD simulations." J Mol Biol 267(4): 1012-1025. Nardin, E., R. W. Gwadz et al. (1979). "Characterization of sporozoite surface antigens by indirect immunofluorescence: detection of stage- and species-specific antimalarial antibodies." Bull. WHO 57 (Suppl. 1): 211-217. Nardin, E. H., V. Nussenzweig et al. (1982). "Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax." J Exp Med 156: 20-30. Nardin, E. H., P. J. Barr et al. (1987). "Induction of sporozoite- specific memory cells in mice immunized with a recombinant Plasmodium vivax circumsporozoite protein." Eur J Immunol 17: 1763-1767. Nardin, E. H., P. J. Barr et al. (1988). "Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein." Eur J Immunol 18(1119): 1119-1122. Nardin, E., P. Clavijo et al. (1991). "T cell epitopes of the circumsporozoite protein of Plasmodium vivax." J Immunol 146(5): 1674-1678. Nardin, E., Y. D. Munesinghe et al. (1992). "T-cell responses to repeat and non-repeat regions of the circumsporozoite protein detected in volunteers immunized with Plasmodium falciparum sporozoites." Mem Inst Oswaldo Cruz 87(Suppl. 3): 223-227. Nardin, E. H. and R. S. Nussenzweig (1993). "T-cell responses to pre-erythrocytic stages of malaria - role in protection and vaccine development against pre-erythrocytic stages." Annu. Rev. Immunol 11: 687-727. Nardin, E. H., G. A. Oliveira et al. (1995). "The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases." Adv Immunol 60: 105-149. Nardin, E. H., J. M. Calvo-Calle et al. (1998). "Plasmodium falciparum polyoximes: highly immunogenic synthetic vaccines constructed by chemoselective ligation of repeat B-cell epitopes and a universal T-cell epitope of CS protein." Vaccine 16(6): 590- 600. Nixon, D. F., C. Hioe et al. (1996). "Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity." Vaccine 14(16): 1523-1530. Norazmi, M. N. and J. W. Dale (1997). "Cloning and expression of a candidate malarial epitope in bacille Calmette Guerin." Biotechnol. Lett. 19(11): 1135-1137. Nussenzweig, V. and R. S. Nussenzweig (1985). "Circumsporozoite proteins of malaria parasites." Cell 42: 401-403. Nussenzweig, V. and R. S. Nussenzweig (1989). "Rationale for the development of an engineered sporozoite malaria vaccine." Adv Immunol 45: 283-334. Nussenzweig, R. S. and F. Zavala (1997). "A malaria vaccine based on a sporozoite antigen." N Engl J Med 336(2): 128-130. Nuzzolo, C. A., A. Bernardi et al. (1990). "A rapid inhibition micro ELISA for detecting antibodies to Plasmodium falciparum sporozoites in human blood." J. Immunoassay 11(4): 389-412. Nwagwu, M., C. A. Anumudu et al. (1998). "Identification of a subpopulation of immune nigerian adult volunteers by antibodies to the circumsporozoite protein of Plasmodium falciparum." Am J Trop Med Hyg 58(5): 684-692. Ockenhouse, C. F., P.-F. Sun et al. (1998). "Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria." J Infect Dis 177: 1664-1673. Oliveira-Ferreira, J., C. R. Nakaie et al. (1992). "Low frequency of anti-Plasmodium falciparum circumsporozoite repeat antibodies and rate of high malaria transmission in endemic areas of Rondonia State in Northwestern Brazil." Am J Trop Med Hyg 46(6): 720-726. Ozaki, L. S., P. Svec et al. (1983). "Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein." Cell 34: 815-822. Pancake, S. J., G. D. Holt et al. (1992). "Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates." J. Cell Biol. 117(6): 1351-1357. Pang, L. W., N. Limsomwong et al. (1988). "Circumsporozoite antibodies and falciparum malaria incidence in children living in a malaria endemic area." Bull Who 66(359): 359-363. Parker, S. E., F. Borellini et al. (1999). "Plasmid DNA malaria vaccine: tissue distribution and safety studies in mice and rabbits." Hum. Gene Ther. 10(5): 741-758. Perkins, D. L., G. Berriz et al. (1991). "Immunodominance: intramolecular competition between T cell epitopes." J Immunol 146(7): 2137-2144. Perraut, R., A. R. Lussow et al. (1993). "Successful primate immunization with peptides conjugated to purified protein derivative or mycobacterial heat shock proteins in the absence of adjuvants." Clin. Exp Immunol 93(3): 382-386. Perraut, R., P. Chouteau et al. (1994). "Assays for adjuvanticity of new formulations and of carrier proteins for inducing antibody responses to selected immunogens in the squirrel monkey Saimiri sciureus." Immun Cell Biol 72(2): 169-175. Pessi, A., D. Valmori et al. (1991). "Lack of H-2 restriction of the Plasmodium-falciparum (NANP) sequence as multiple antigen peptide." Eur J Immunol 21(9): 2273-2276. Plebanski, M., S. C. Gilbert et al. (1998). "Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use." Eur J Immunol 28(12): 4345-4355. Plebanski, M., K. L. Flanagan et al. (1999). "Interleukin 10- mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum." Immunity 10(6): 651-660. Pombo, D., W. L. Maloy et al. (1988). "Neonatal exposure to immunogenic peptides: Differential susceptibility to tolerance induction of helper T cells and B cells reactive to malarial circumsporozoite peptide epitopes." J Immunol 140(10): 3594-3598. Posthuma, G., J. F. Meis et al. (1988). "Immunogold localization of circumsporozoite protein of the malaria parasite Plasmodium falciparum during sporogony in Anopheles stephensi midguts." Eur J Cell Biol 46(18): 18-24. Posthuma, G., J. F. Meis et al. (1989). "Immunogold determination of Plasmodium falciparum circumsporozoite protein in Anopheles stephensi salivary gland cells." Eur J Cell Biol 49(66): 66-72. Potocnjak, P., N. Yoshida et al. (1980). "Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection." J Exp Med 151: 1504-1513. Procell, P. M., W. E. Collins et al. (1988). "Circumsporozoite protein of the human malaria parasite Plasmodium ovale identified with monoclonal antibodies." Infect Immun 56: 376-379. Procell, P., I. C. Bathurst et al. (1991). "Cellular proliferative responses in squirrel monkeys immunized with recombinant and synthetic Plasmodium vivax circumsporozoite peptides." Am J Trop Med Hyg 44(6): 632-639. Pyper, W. R., M. Tchavtchitch et al. (1998). "The circumsporozoite protein of Plasmodium chabaudi contains a large, pre-region I repeat domain." Mol Biochem Parasitol 94(2): 287-289. Qari, S. H., I. F. Goldman et al. (1991). "Wide distribution of the variant form of the human malaria parasite Plasmodium vivax." J Biol Chem 266(25): 16297-16300. Qari, S. H., I. F. Goldman et al. (1992). "Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax." Mol Biochem Parasitol 55(1-2): 105-113. Qari, S. H., Y. P. Shi et al. (1993). "Global occurrence of Plasmodium vivax-like human malaria parasite." J Infect Dis 168(6): 1485-1489. Quakyi, I. A., L. N. Otoo et al. (1989). "Differential non- responsiveness in humans of candidate Plasmodium falciparum vaccine antigens." Am J Trop Med Hyg 41: 125-134. Que, J. U., S. J. Cryz et al. (1988). "Effect of carrier selection on immunogenicity of protein conjugate vaccines against Plasmodium falciparum circumsporozoites." Infect Immun 56(2645): 2645-2649. Ramasamy, R., K. Nagendran et al. (1994). "Antibodies to epitopes on merozoite and sporozoite surface antigens as serologic markers of malaria transmission: studies at a site in the dry zone of Sri Lanka." Am J Trop Med Hyg 50(5): 537-547. Ramirez, A. D., E. M. M. Rocha et al. (1995). "Antisporozoite antibodies with protective and nonprotective activities: in vitro and in vivo correlations using Plasmodium gallinaceum, an avian model." J. Eukaryot. Microbiol. 42(6): 705-708. Ranjit, M. R. and Y. D. Sharma (1999). "Genetic polymorphism of falciparum malaria vaccine candidate antigen genes among field isolates in India." Am J Trop Med Hyg 61(1): 103-108. Rattanarithikul, R., E. Konishi et al. (1996). "Detection of Plasmodium vivax and Plasmodium falciparum circumsporozoite antigen in anopheline mosquitoes collected in southern Thailand." Am J Trop Med Hyg 54(2): 114-121. Reber-Liske, R., L. A. Salako et al. (1995). "[NANP]19-5.1 - a malaria vaccine field trial in Nigerian children." Trop Geogr Med 47(2): 61-63. Reed, R. C., V. Louis-Wileman et al. (1996). "Re-investigation of the circumsporozoite protein-based induction of sterile immunity against Plasmodium berghei infection." Vaccine 14(8): 828-836. Reed, R. C., A. F. Verhuel et al. (1997). "Rapid onset of malaria- induced mortality by immunizations with lipo-peptides: an experimental model to study deleterious immune responses and immunopathology in malaria." Vaccine 15(1): 65-70. Renggli, J., D. Valmori et al. (1995). "CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS protein-derived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria." Immunol Lett. 46(1-2): 199-205. Rénia, L., M. S. Marussig et al. (1991). "In vitro activity of CD4+ and CD8+ T lymphocytes from mice immunized with a synthetic malaria peptide." Proc Natl Acad Sci USA 88(18): 7963-7967. Rénia, L., D. Grillot et al. (1993). "Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages." J Immunol 150(4): 1471-1478. Rich, K. A., F. W. George et al. (1990). "Cell-adhesive motif in Region II of malarial circumsporozoite protein." Science 249(4976): 1574-1577. Rich, S. M., R. R. Hudson et al. (1997). "Plasmodium falciparum antigenic diversity: evidence of clonal population structure." Proc Natl Acad Sci USA 94(24): 13040-13045. Rich, S. M. and F. J. Ayala (1998). "The recent origin of allelic variation in antigenic determinants of Plasmodium falciparum." Genetics 150(1): 515-517. Rickman, L. S., D. M. Gordon et al. (1991). "Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine." Lancet 337(8748): 998-1001. Riley, E. M., S. J. Allen et al. (1990). "Recognition of dominant T cell-stimulating epitopes from the circumsporozoite protein of Plasmodium falciparum and relationship to malaria morbidity in Gambian children." Trans R Soc Trop Med Hyg 84(5): 648-657. Ritu, G. and D. N. Rao (1992). "Construction of synthetic immunogens: Use of T- and B-cell epitopes of CS and RESA proteins of Plasmodium falciparum." Vaccine 10(11): 761-765. Rocha, E. M. M., M. R. Hollingdale et al. (1993). "Common epitopes in the circumsporozoite proteins of Plasmodium berghei and Plasmodium gallinaceum identified by monoclonal antibodies to the P. gallinaceum circumsporozoite protein." J Eukaryot Microbiol 40(1): 61-63. Rodrigues, M. M., A. Paiva et al. (1991). "Identification of epitopes within the circumsporozoite protein of Plasmodium vivax recognized by murine T lymphocytes." Exp Parasitol 72(3): 271-277. Rodrigues, M. M., A. S. Cordey et al. (1991). "CD8+ cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria." Int Immunol 3(6): 579-585. Rodrigues, M. M., A. P. Dutra et al. (1991). "Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax." Mem Inst Oswaldo Cruz 86(2): 153-158. Rodrigues, M., R. S. Nussenzweig et al. (1992). "The invivo cytotoxic activity of CD8+ T-cell clones correlates with their levels of expression of adhesion molecules." J Exp Med 175(4): 895-905. Rodrigues, E. G., F. Zavala et al. (1997). "Single immunizing dose of recombinant adenovirus efficiently induces CD8+ cell-mediated protective immunity against malaria." J Immunol 158(3): 1268-1274. Rodrigues, E. G., F. Zavala et al. (1998). "Efficient induction of protective antimalaria immunity by recombinant adenovirus." Vaccine 16(19): 1812-1817. Rodriguez, M. H., L. Gonzalez-Ceron et al. (2000). "Different prevalences of Plasmodium vivax phenotypes VK210 and VK247 associated with the distribution of Anopheles albimanus and Anopheles pseudopunctipennis in Mexico." Am J Trop Med Hyg 62(1): 122-127. Rogers, W. O., M. D. Rogers et al. (1992). "Characterization of the gene encoding sporozoite surface protein 2, a protective Plasmodium yoelii sporozoite antigen." Mol Biochem Parasitol 53 (1-2): 45-51. Rogers, W. O., K. Gowda et al. (1999). "Construction and immunogenicity of DNA vaccine encoding four Plasmodium vivax candidate vaccine plasmids antigens." Vaccine 17(23-24): 3136- 3144. Roggero, M. A., B. Filippi et al. (1995). "Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum CS protein." Mol Immunol 32(17-18): 1301-1309. Romero, P., E. P. Heimer et al. (1987). "Antigenic analysis of the repeat domain of the circumsporozoite protein of Plasmodium vivax." J Immunol 139: 1679-1682. Romero, P. J., J. P. Tam et al. (1988). "Multiple T helper cell epitopes of the circumsporozoite protein of Plasmodium berghei." Eur J Immunol 18(1951): 1951-1957. Romero, P., G. Corradin et al. (1991). "H-2Kd-restricted antigenic peptides share a simple binding motif." J Exp Med 174(3): 603-612. Romero, P., G. Eberl et al. (1992). "Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule." J Immunol 148(6): 1871- 1878. Romero, P., J. C. Cerottini et al. (1994). "Efficient in vivo induction of CTL by cell-associated covalent H-2Kd-peptide complexes." J Immunol Methods 171(1): 73-84. Romi, R., G. Sabatinelli et al. (1994). "Plasmodium falciparum circumsporozoite antibody prevalence in Madagascar: a longitudinal study in three different epidemiologic areas." Am J Trop Med Hyg 51(6): 856-863. Romieu, R., M. Baratin et al. (1998). "IFN-g-secreting Th cells regulate both the frequency and avidity of epitope-specific CD8+ T lymphocytes induced by peptide immunization: an ex vivo analysis." Int Immunol 10(9): 1273-1279. Rongnoparut, P., N. Supsamran et al. (1995). "Phenotype and genotype diversity in the circumsporozoite proteins of Plasmodium vivax in Thailand." Mol Biochem Parasitol 74(2): 201-210. Rosenberg, R., R. A. Wirtz et al. (1989). "Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax." Science 245: 973-976. Rosenberg, R. and R. A. Wirtz (1990). "Intrinsic individual differences in circumsporozoite antibody response at a hyperendemic malaria focus." Trans R Soc Trop Med Hyg 84(2): 206- 208. Ruegg, C. L., R. I. Jaffe et al. (1990). "Preparation of proteosome-based vaccines Correlation of immunogenicity with physical characteristics." J Immunol Methods 135(1-2): 101-109. Ruiz, i. A. A., L. S. Ozaki et al. (1986). "Expression of the Plasmodium knowlesi circumsporozoite antigen in Escherichia coli directed by Plasmodium bacterial-like promoter sequences." Gene 41(135): 135-144. Ruiz, i. A. A., L. S. Ozaki et al. (1987). "Organization and expression of the Plasmodium knowlesi circumsporozoite antigen gene." Mol Biochem Parasitol 23(233): 233-245. Russo, D. M., J. S. Sundy et al. (1989). "Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of Plasmodium falciparum." J Immunol 143: 655-659. Sabatinelli, G., R. Romi et al. (1996). "Age-related prevalence of Plasmodium falciparum circumsporozoite antibody in an hyperendemic area of Madagascar, and its relationship with parasite prevalence." Am J Trop Med Hyg 55(3): 278-281. Sadoff, J. C., W. R. Ballou et al. (1988). "Oral Salmonella typhimurium vaccine expressing circumsporozoite protein protects against malaria." Science 240: 336-338. Satchidanandam, V., F. Zavala et al. (1991). "Studies using a recombinant vaccinia virus expressing the circumsporozoite protein of Plasmodium berghei." Mol Biochem Parasitol 48(1): 89-100. Satchidanandam, V., F. Zavala et al. (1991). "Studies using a recombinant vaccinia virus expressing the circumsporozoite protein of Plasmodium berghei." Mol Biochem Parasitol 48(1): 89-99. Schlesinger, D. H., A. H. Cochrane et al. (1984). "Structure of an immunodominant epitope of the circumsporozoite surface protein of Plasmodium knowlesi." Biochemistry 23: 5665-5670. Schneider, J., S. C. Gilbert et al. (1998). "Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara." Nature Med. 4(4): 397-402. Schneider, J., S. C. Gilbert et al. (1999). "Induction of CD8+ T cells using heterologous prime-boost immunisation strategies." Immunol Rev. 170: 29-38. Schofield, L. (1990). "The circumsporozoite protein of Plasmodium: A mechanism of immune evasion by the malaria parasite?" Bull Who 68(66): 66-73. Schofield, L. and P. Uadia (1990). "Lack of Ir gene control in the immune response to malaria. I. A thymus-independent antibody response to the repetitive surface protein of sporozoites." J Immunol 144: 2781-2788. Schödel, F., R. Wirtz et al. (1994). "Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes." J Exp Med 180(3): 1037-1046. Sedegah, M., R. L. Beaudoin et al. (1990). "Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: Vaccinia, pseudorabies, and salmonella transformed with circumsporozoite gene." Bull Who 68(109): 109-114. Sedegah, M., B. K. L. Sim et al. (1992). "Naturally acquired CD8+ cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein." J Immunol 149(3): 966-971. Sedegah, M., C. H. Chiang et al. (1992). "Recombinant pseudorabies virus carrying a plasmodium gene: herpesvirus as a new live viral vector for inducing T- and B-cell immunity." Vaccine 10(9): 578- 584. Sedegah, M., R. Hedstrom et al. (1994). "Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein." Proc Natl Acad Sci USA 91(21): 9866-9870. Sethabutr, O., A. E. Brown et al. (1992). "Detection of Plasmodium falciparum by polymerase chain reaction in a field study." J Infect Dis 166(1): 145-148. Shakibaei, M. and U. Frevert (1996). "Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans." J Exp Med 184(5): 1699-1711. Sharma, S., P. Svec et al. (1985). "Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi." Science 229: 779-782. Sharma, P., A. Bharadwaj et al. (1996). "Antibodies to a conserved-motif peptide sequence of the Plasmodium falciparum thrombospondin-related anonymous protein and circumsporozoite protein recognize a 78-kilodalton protein in the asexual blood stages of the parasite and inhibit merozoite invasion in vitro." Infect Immun 64(6): 2172-2179. Sharma, S., A. Goswami et al. (1996). "Immunogenicity of the nonrepetitive regions of the circumsporozoite protein of Plasmodium knowlesi." Am J Trop Med Hyg 55(6): 635-641. Sherwood, J. A., C. N. Oster et al. (1991). "Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria." Trans Roy Soc Trop Med Hyg 85(3): 336-340. Sherwood, J. A., R. S. Copeland et al. (1996). "Plasmodium falciparum circumsporozoite vaccine immunogenicity and efficacy trial with natural challenge quantitation in an area of endemic human malaria of Kenya." Vaccine 14(8): 817-827. Shi, Y.-P., M. P. Alpers et al. (1992). "Diversity in the immunodominant determinants of the circumsporozoite protein of Plasmodium falciparum parasites from malaria-endemic regions of Papua New Guinea and Brazil." Am J Trop Med Hyg 47(6): 844-851. Shi, Y. P., V. Udhayakumar et al. (1993). "Natural antibody responses against the non-repeat-sequence-based B-cell epitopes of the Plasmodium falciparum circumsporozoite protein." Infect Immun 61(6): 2425-2433. Shi, Y. P., S. E. Hasnain et al. (1999). "Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine." Proc Nat Acad Sci USA 96(4): 1615- 1620. Sidjanski, S. P., J. P. Vanderberg et al. (1997). "Anopheles stephensi salivary glands bear receptors for region I of the circumsporozoite protein of Plasmodium falciparum." Mol Biochem Parasitol 90(1): 33-41. Sina, B. J., C. Wright et al. (1992). "A protective monoclonal antibody with dual specificity for Plasmodium falciparum and Plasmodium berghei circumsporozoite proteins." Exp Parasitol 74(4): 431-440. Sina, B. J., V. E. do Rosario et al. (1993). "Plasmodium falciparum sporozoite immunization protects against Plasmodium berghei sporozoite infection." Exp Parasitol 77(2): 129-135. Sina, B. J., C. Wright et al. (1995). "Characterization of a sporozoite antigen common to Plasmodium falciparum and Plasmodium berghei." Mol Biochem Parasitol 69(2): 239-246. Sinigaglia, F., M. Guttinger et al. (1988). "Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein." Eur J Immunol 18: 633-636. Sinigaglia, F., M. Guttinger et al. (1988). "A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules." Nature (London) 336: 778-780. Sinigaglia, F., M. Guttinger et al. (1990). "An invariant, "universal" T-cell epitope in the P. falciparum circumsporozoite protein." Bull Who 68(94): 94-98. Sinnis, P., P. Clavijo et al. (1994). "Structural and functional properties of region II-plus of the malaria circumsporozoite protein." J Exp Med 180(1): 297-306. Sinnis, P. (1996). "The malaria sporozoite's journey into the liver." Infect Agents Dis 5(3): 182-189. Sinnis, P. (1998). "An immunoradiometric assay for the quantification of Plasmodium sporozoite invasion of HepG2 cells." J Immunol Meth 221(1-2): 17-23. Siu, N. F., S. L. French et al. (1995). "Plasmodium yoelii: expression of circumsporozoite protein and sporozoite surface protein 2 by sporozoites in culture." Exp Parasitol 81(4): 600- 603. Stephens, H. A. F., A. E. Brown et al. (1995). "The presence of the HLA class II allele DPB1*0501 in ethnic Thais correlates with an enhanced vaccine-induced antibody response to a malaria sporozoite antigen." Eur J Immunol 25(11): 3142-3147. Stewart, M. J. and J. P. Vanderberg (1988). "Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility." J Protozool 35(389): 389-393. Stewart, M. J. and J. P. Vanderberg (1991). "Malaria sporozoites release circumsporozoite protein from their apical end and translocate it along their surface." J Protozool 38(4): 411-421. Stewart, M. J. and J. P. Vanderberg (1992). "Electron microscopic analysis of circumsporozoite protein trail formation by gliding malaria sporozoites." J Protozool 39(6): 663-671. Stirnadel, H. A., H.-P. Beck et al. (1999). "Heritability and segregation analysis of immune responses to specific malaria antigens in Papua New Guinea." Genet. Epidemiol. 17(1): 16-34. Stirnadel, H. A. (1999). The relative contribution of genetic and environmental factors to variation in malaria immunity, infection and related morbidity, in areas highly endemic for Plasmodium falciparum, University of Basel, Switzerland. Stoute, J. A., K. E. Kester et al. (1998). "Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine." J Infect Dis 178(4): 1139-1144. Stuber, D., W. Bannwarth et al. (1990). "New B cell epitopes in the Plasmodium falciparum malaria circumsporozoite protein." Eur J Immunol 20(4): 819-24. Stürchler, D., R. Berger et al. (1989). "Effects of interferons on immune response to a synthetic peptide malaria sporozoite vaccine in non-immune adults." Vaccine 7: 457-461. Stürchler, D., M. Just et al. (1992). "Evaluation of 5.1-[NANP]19, a recombinant Plasmodium falciparum vaccine candidate, in adults." Trop. Geogr. Med. 44: 9-14. Suhrbier, A., A. J. Hamilton et al. (1988). "The fate of the circumsporozoite antigens during the exoerythrocytic stage of Plasmodium berghei." Eur J Cell Biol 46(25): 25-30. Suhrbier, A. (1991). "Rodent malaria models - reply." Parasitol Today 7(12): 340-341. Suhrbier, A. (1991). "Immunity to the liver stage of malaria." Parasitol Today 7(7): 160-163. Suwanabun, N., J. Sattabongkot et al. (1994). "The epidemiology of Plasmodium vivax circumsporozoite protein polymorphs in Thailand." Am J Trop Med Hyg 50(4): 460-464. Tahar, R., P. Ringwald et al. (1998). "Heterogeneity in the circumsporozoite protein gene of Plasmodium malariae isolates from sub-Saharan Africa." Mol Biochem Parasitol 92(1): 71-78. Takacs, B. J. and M. F. Girard (1991). "Preparation of clinical grade proteins produced by recombinant DNA technologies." J Immunol Methods 143(2): 231-240. Takita-Sonoda, Y., M. Tsuji et al. (1996). "Plasmodium yoelii: peptide immunization induces protective CD4+ T cells against a previously unrecognized cryptic epitope of the circumsporozoite protein." Exp Parasitol 84(2): 223-230. Tam, J. P., P. Clavijo et al. (1990). "Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria." J Exp Med 171(1): 299-306. Tapchaisri, P., P. Dekumyoy et al. (1985). "Antibodies against circumsporozoite proteins of Plasmodium falciparum induced by natural infection." Southeast Asian J Trop Med Public Health 16(355): 355-364. Tapchaisri, P., P. Dekumyoy et al. (1986). "Occurrence of a common epitope in circumsporozoite proteins of Plasmodium falciparum isolated from different areas in Thailand." Southeast Asian J Trop Med Public Health 17(13): 13-18. Tegoshi, T., J. R. Broderson et al. (1991). "Renal pathology in Saimiri monkeys during a vaccine trial using the recombinant circumsporozoite protein of Plasmodium vivax." Am J Trop Med Hyg 44(4): 406-412. Thomasin, C., G. Corradin et al. (1996). "Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/poly(lactide- co-glycolide) microspheres: importance of polymer degradation and antigen release for immune response." J. Control. Release 41(1-2): 131-145. Tine, J. A., D. E. Lanar et al. (1996). "NYVAC-Pf7: a poxvirus- vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria." Infect Immun 64(9): 3833-3844. Togna, A. R., D. G. G. et al. (1986). "Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice." J Immunol 137: 2956- 2960. Tomita, K. (1992). "Structural studies of malaria vaccine." Yakugaku Zasshi-J. Pharm. Soc. Jap. 112(12): 873-886. Trottein, F., T. Triglia et al. (1995). "Molecular cloning of a gene from Plasmodium falciparum that codes for a protein sharing motifs found in adhesive molecules from mammals and Plasmodia." Mol Biochem Parasitol 74(2): 129-141. Tsuji, M., P. Romero et al. (1990). "CD4+ cytolytic T cell clone confers protection against murine malaria." J Exp Med 172: 1353- 1357. Tsuji, M., G. Corradin et al. (1992). "Monoclonal antibodies recognize a processing dependent epitope present in the mature CS protein of various plasmodial species." Parasite Immunol 14(5): 457-469. Tsuji, M., C. C. Bergmann et al. (1998). "Recombinant sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice." J Virol 72(8): 6907-6910. Tuszynski, G. P., V. L. Rothman et al. (1992). "Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins." J. Cell Biol. 116(1): 209-217. Udhayakumar, V., Y.-P. Shi et al. (1994). "Antigenic diversity in the circumsporozoite protein of Plasmodium falciparum abrogates cytotoxic-T-cell recognition." Infect Immun 62(4): 1410-1413. Udhayakumar, V., J. M. Ongecha et al. (1997). "Cytotoxic T cell reactivity and HLA-B35 binding of the variant Plasmodium falciparum circumsporozoite protein CD8+ CTL epitope in naturally exposed Kenyan adults." Eur J Immunol 27(8): 1952-1957. Udhayakumar, V., A. Saekhou et al. (1998). "Immunogenicity of Plasmodium falciparum and Plasmodium vivax circumsporozoite protein repeat multiple antigen constructs (MAC)." Vaccine 16(9- 10): 982-988. Valmori, D., J. F. Romero et al. (1994). "Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): further enhancement by pre-injection of IFA alone." Eur J Immunol 24(6): 1458-1462. Vanderberg, J. P. (1991). "Rodent malaria models." Parasitol Today 7(12): 340. Verdini, A. S., L. Chiappinelli et al. (1991). "Toward the elucidation of the mechanism of attachment and entry of malaria sporozoites into cells: synthetic polypeptides from the circumsporozoite protein of Plasmodium falciparum bind Ca2+ and interact with model phospholipid membranes." Biopolymers 31(6): 587-94. Vergara, U., R. Gwadz et al. (1985). "Multiple non-repeated epitopes on the circumsporozoite protein of Plasmodium knowlesi." Mol Biochem Parasitol 14: 283-292. Vergara, U., A. Ruiz et al. (1985). "Conserved group-specific epitopes of the circumsporozoite proteins revealed by antibodies to synthetic peptides." J Immunol 134(5): 3445-3448. Verheul, A. F. M., V. Udhayakumar et al. (1995). "Monopalmitic acid-peptide conjugates induce cytotoxic T cell responses against malarial epitopes: importance of spacer amino acids." J Immunol Methods 182(2): 219-226. Viscomi, G. C., A. Ziggiotti et al. (1989). "Preparative purification of Plasmodium falciparum circumsporozoite protein synthetic polypeptides by displacement chromatography." J Chromatogr 482(1): 99-106. Vreden, S., J. P. Verhave et al. (1991). "Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen." Am J Trop Med Hyg 45(5): 533-538. Vreden, S. G., J. P. Verhave et al. (1991). "Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen." Am J Trop Med Hyg 45(5): 533-8. Wang, R. B., Y. Charoenvit et al. (1995). "Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine." J Immunol 154(6): 2784-2793. Wang, H. H., W. O. Rogers et al. (1995). "Partial protection against malaria by immunization with Leishmania enriettii expressing the Plasmodium yoelii circumsporozoite protein." Mol Biochem Parasitol 69(2): 139-148. Wang, R. B., Y. Charoenvit et al. (1996). "Protective efficacy against malaria of a combination sporozoite and erythrocytic stage vaccine." Immunol Lett. 53(2-3): 83-93. Wang, R. B., D. L. Doolan et al. (1998). "Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids." Infect Immun 66(9): 4193-4202. Wang, R. B., D. L. Doolan et al. (1998). "Induction of antigen- specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine." Science 282(5388): 476-480. Warburg, A., M. Touray et al. (1992). "Plasmodium gallinaceum: Antibodies to circumsporozoite protein prevent sporozoites from invading the salivary glands of Aedes aegypti." Exp Parasitol 75(3): 303-307. Weber, J. L. and W. T. Hockmeyer (1985). "Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum." Mol Biochem Parasitol 15: 305-316. Weber, J. L., J. E. Egan et al. (1987). "Plasmodium berghei: cloning of the circumsporozoite protein gene." Exp Parasitol 63(295): 295-300. Webster, H. K., J. B. Gingrich et al. (1992). "Circumsporozoite antibody as a serologic marker of plasmodium falciparum transmission." Am J Trop Med Hyg 47(4): 489-497. Weiss, W. R., R. A. Houghten et al. (1990). "A CTL epitope on the circumsporozoite protein of P. yoelii." Bull Who 68(99): 99-103. Weiss, W. R., J. A. Berzofsky et al. (1992). "A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei." J Immunol 149(6): 2103-2109. Weiss, W. R., K. J. Ishii et al. (1998). "A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine." J Immunol 161(5): 2325-2332. White, K. L., D. L. Jarboe et al. (1994). "Immunization with irradiated Plasmodium berghei sporozoites induces IL-2 and IFNg but not IL-4." Parasite Immunol 16(9): 479-491. White, K. L., H. L. Snyder et al. (1996). "MHC class I-dependent presentation of exoerythrocytic antigens to CD8+ T lymphocytes is required for protective immunity against Plasmodium berghei." J Immunol 156(9): 3374-3381. Widmann, C., P. Romero et al. (1992). "T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I- restricted malaria peptides." J Immunol Methods 155(1): 95-99. Wiesmüller, K. H., G. Jung et al. (1991). "The antibody response in BALB/c mice to the Plasmodium falciparum circumsporozoite." Immunology 72(1): 109-113. Wilson, D. R. and B. B. Finlay (1997). "The 'Asx-Pro turn' as a local structural motif stabilized by alternative patterns of hydrogen bonds and a consensus-derived model of the sequence Asn- Pro-Asn." Protein Eng. 10(5): 519-529. Wilson, D. R., R. A. Wirtz et al. (1997). "Recognition of phage- expressed peptides containing Asx-Pro sequences by monoclonal antibodies produced against Plasmodium falciparum circumsporozoite protein." Protein Eng. 10(5): 531-540. Wirtz, R. A., W. R. Ballou et al. (1987). "Plasmodium falciparum: immunogenicity of circumsporozoite protein constructs produced in Escherichia coli." Exp Parasitol 63: 166-172. Wirtz, R. A., R. Rosenberg et al. (1990). "Prevalence of antibody to heterologous circumsporozoite protein of Plasmodium vivax in Thailand." Lancet 336(8715): 593-595. Wohlhueter, R. M., K. Parekh et al. (1994). "Analysis of binding of monoclonal antibody to a malarial peptide by surface plasmon resonance biosensor and integrated rate equations." J Immunol 153(1): 181-189. Wong, R. S. Y. and R. E. W. Hancock (1996). "The effect of the length of a malarial epitope on its antigenicity and immunogenicity in an epitope presentation system using the Pseudomonas aeruginosa outer membrane protein OprF as the carrier." FEMS Microbiol. Lett. 140(2-3): 209-214. Wongsrichanalai, C., H. K. Webster et al. (1991). "Naturally acquired circumsporozoite antibodies and their role in protection in endemic falciparum and vivax malaria." Am J Trop Med Hyg 44(2): 201-204. Yang, C. F., W. E. Collins et al. (1997). "Induction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin." Vaccine 15(4): 377-386. Ying, P., M. Shakibaei et al. (1997). "The malaria circumsporozoite protein: interaction of the conserved regions i and II-plus with heparin-like oligosaccharides in heparan sulfate." Exp Parasitol 85(2): 168-182. Yoshida, N., R. S. Nussenzweig et al. (1980). "Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite." Science 207: 71-73. Yoshida, N., P. H. del et al. (1987). "Plasmodium falciparum: epidemiological studies on the circumsporozoite gene." Exp Parasitol 64(510): 510-513. Yoshida, N., S. S. Di et al. (1990). "Plasmodium falciparum: Restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil." Exp Parasitol 71(4): 386-392. Young, J. F., W. T. Hockmeyer et al. (1985). "Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine." Science 228(958): 958-962. Zavala, F., R. W. Gwadz et al. (1982). "Monoclonal antibodies to circumsporozoite proteins identify the species of malaria parasite in infected mosquitoes." Nature 299(737): 737-738. Zavala, F., A. H. Cochrane et al. (1983). "Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes." J Exp Med 157: 1947- 1957. Zavala, F., J. P. Tam et al. (1986). "Synthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites." J Immunol Meth 93: 55-61. Zavala, F. (1991). "The multifactorial character of the protective immunity induced by immunization with sporozoites." Res. Immunol 142(8): 654-658. Zevering, J., R. A. Houghten et al. (1990). " Major population differences in T cell response to a malaria sporozoite vaccine candidate." Int Immunol 2: 945-955. Zevering, Y., C. Khamboonruang et al. (1994). "Natural amino acid polymorphisms of the circumsporozoite protein of Plasmodium falciparum abrogate specific human CD4+ T cell responsiveness." Eur J Immunol 24(6): 1418-1425.