`<EE @@@ @@@@B2b9jL&zEE EN DB E  E.p y j>X`    Z\^- RRSSSSTTTT bbbb ccccddccddHЀА @?/.N>\-@ n PPC n PC /.J-gr/.N X=@ n"n"Q0)n P1@ n"n"Q PP n PphJ@f0-n n PphJ@fTnHnBg?.Rn0.nm!t tN N^NuNV/.NBX?<NTJ-g\N/-礩m m PCA""Hn?TNLN^NuNV/.NX0m瞰gN/. /./-砩NN^NuNV/.NX0m瞰gBgN TN*/-砩N^NuNV/.NdX0m瞰g*BgN TNNNz/-砩NNBgN TN^NuNV/.NX0m瞰g*BgN nTNNN4/-砩NlNjBgN LTN^NuNV/.NX0m瞰g,BgN (TNpNtN/-NJN$N"BgN TN^NuNV/.NX0m瞰f nB nB n B`NBBHyTEXTHn -@ n  m"m8 Adams1996 Adams1998 Adams1998Alderson1982Alderson1984 Alderson19849 Amante19979 Anders19898 Anders19900 Anders19909& Anders19911% Anders19939 Anders19966 Anders19966+ Anders19969 Anders19979 Anders19979 Anders19986 Anders19989 Ayala19986 Ballou19989  Bannister1990' Bannister1998,Billman-Jacobe1999 Blair1998 Bloland19967 Bloland1996 Carr19909 Chauhan1995. Cheng19946 Church19981 Cohen1984 Cohen1984 Cohen1988 Cohen1990 Collins1990" Collins1994: Collins1999 Cooper19909% Coppel19939" Coppel19944+ Coppel19969, Coppel1999o&Corcoran19911Crewther1989Crewther19900"Crewther19944Crewther1996Crewther1996Crewther19978Crewther1997Crewther19986Crutcher19989Culvenor199006 de Taisne1998 Deans1982 Deans1984 Deans1984 Deans1984 Deans1987 Deans1988 Deans1990* Dennis19949* Druilhe1994' Dubbeld1998 Dubbeld1999 Dutta1995& Edwards1991" Edwards1994 Edwards1998, Eisen1999 Elliott1990 Escalante1998& et al.19911" et al.199496 Farley19981 Feng19955 Feng19955 Flegg1996 Foley1997& Franchina1991 Fraser1998 Fu1997: Fujioka1999" Galland1994( Goncalves1994* Goncalves1994 Good199799 Gowda19996 Guito19986 Hall19989: Hasnain1999 Hawley199667 Hawley19966 Haynes19979 Hightower19966 Hill19989 Hodder199666 Hoffman19989 Hoffman1999: Hoffman1999:Holloway19996 Horii1998 Hudson19909 Hughes19966; Hughes2000< Janse1997' Janse1998 Jean19877 Jean198888 Kappe1996 Kappe19986 Kaslow19981 Kemp19891 Kemp19898 Kemp19909" Kemp199496 Kester19981 Khurana1996 Knight19888' Kocken1998 Kocken19996 Krzych199816 Kumar1998: Kumar1999 Lal19967 Lal1996 Lal1998: Lal19996 Lalvani19986 Lanar1998 Langermans19999 Lennox19828 Lew1989 Lew19896 Magill19981Malhotra19959Margetts1998Marshall1989Marshall1989Marshall19909+Marshall1996,Marshall1999 Matthew1996 Matthew1996 Matthew1998% McColl19939 McCutchan1990 McCutchan1991 Miller19909Mitchell1982 Mitchell19849Mitchell1988Mitchell19900Mitchell1991*Mitchell19944& Monger19919 Moritz19966 Nahlen199697 Nahlen19966( Narum1994) Narum1994* Narum1994' Narum1998 Nelson19969 Nguyen-Dinh1990 Noe1998 Noe1998& O'Brien19916 Ockenhouse1998Oliveira19967Oliveira1996Z Oloo199697 Oloo199696Paoletti19988Peterson1989Peterson1989Peterson1990&Peterson19911 Pollock1998 Pronk1999& Pye1991" Pye1994 Pye1998 Reid199699 Rogers1999( Rogier19949* Rogier1994( Rosario1994* Rosario1994 S.19821: Sacci19996 Sadoff19981. 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W. Deans, J. A. Mitchell, G. H. Alderson, T. Cohen, S.A~wThe Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes Mol Biochem Parasitole 198413 187r187-199a2,Thomas, A. W. Bannister, L. H. Waters, A. P.Sixty-six kilodalton-related antigens of Plasmodium knowlesi are merozoite surface antigens associated with the apical prominenceParasite Immunol 1990122105-113("Thomas, A.W. Waters, A.P. Carr, D. 1990rkAnalysis of variation in Pf83, an erythrocytic merozoite vaccine candidate antigen of Plasmodium falciparumMol Biochem Parasitol42285-288 Ref1195109845VOThomas, A. W. Trape, J. F. Rogier, C. Goncalves, A. Rosario, V. E. Narum, D. L.iHigh prevalence of natural antibodies against Plasmodium falciparum 83- kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture- enzyme-linked immunosorbent assay using full-length baculovirus recombinant PF83/AMA-1Am J Trop Med HygV 1994516 730-4096002387~Thomas, A. W. Narum, D. Waters, A. P. Trape, J. F. Rogier, C. Goncalves, A. Rosario, V. Druilhe, P. Mitchell, G. H. Dennis, D.f`Aspects of immunity for the AMA-1 family of molecules in humans and non- human primates malariasMem Inst Oswaldo Cruz 199489Suppl 2P 67-70 Verra, F. Hughes, A.L. 2000rEvidence for ancient balanced polymorphism at the Apical Membrane Antigen-1 (AMA-1) locus of Plasmodium falciparum ] Mol. Biochem. Parasitol. 105.1149-153,&Molecular and Biochemical ParasitologyvoWaters, A. P. Thomas, A. W. Deans, J. A. Mitchell, G. H. Hudson, D. E. Miller, L. H. McCutchan, T. F. Cohen, S. 1990voA merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium. J Biol Chem 265 29 17974-17979^ 0947 Ref11B7Amante, F. H. Crewther, P. E. Anders, R. F. Good, M. F.sA cryptic T cell epitope on the apical membrane antigen 1 of Plasmodium chabaudi adami can prime for an anamnestic antibody response: implications for malaria vaccine designH J Immunol 1997 159115535-44r933112460)Anders, R. F. McColl, D. J. Coppel, R. L.4haMolecular variation in Plasmodium falciparum: polymorphic antigens of asexual erythrocytic stagesD Acta Trop 199353 3-4 239-5398269920`YAnders, R. F. Crewther, P. E. Edwards, S. Margetts, M. Matthew, M. L. Pollock, B. Pye, D.Pb\Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudiVaccineS 199816 2-3 240-7nCheng, Q. Saul, A. 1994~NSequence analysis of the apical membrane antigen I (AMA-1) of Plasmodium vivax > Mol. Biochem. Parasitol.651183-187,&Molecular and Biochemical Parasitology Pv MalMol MalAg AMA95109843Collins, W. E. Pye, D. Crewther, P. E. Vandenberg, K. L. Galland, G. G. Sulzer, A. J. Kemp, D. J. Edwards, S. J. Coppel, R. L. Sullivan, J. S. et al.,vpProtective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragileAm J Trop Med HygT 1994516 711-99,&fngPeterson, M. G. Nguyen-Dinh, P. Marshall, V. M. Elliott, J. F. Collins, W. E. Anders, R. F. Kemp, D. J.n4-Apical membrane antigen of Plasmodium fragile.Mol Biochem ParasitolD 1990392 279-83 Ref11n91267620Pye, D. Edwards, S. J. Anders, R. F. O'Brien, C. M. Franchina, P. Corcoran, L. N. Monger, C. Peterson, M. G. Vandenberg, K. L. Smythe, J. A. et al.,|Failure of recombinant vaccinia viruses expressing Plasmodium falciparum antigens to protect Saimiri monkeys against malaria Infect Immun 19915972403-11T*$Rogers, W.O. Gowda, K. Hoffman, S.L. 1999qConstruction and immunogenicity of DNA vaccine encoding four Plasmodium vivax candidate vaccine plasmids antigens = M Vaccine17 23-24 3136-3144^Vaccined@,$96123401,%Dutta, S. Malhotra, P. Chauhan, V. S.B`ZSequence analysis of apical membrane antigen 1 (AMA-1) of Plasmodium cynomolgi bastianelliMol Biochem Parasitole 199573 1-2l 267-7099318271D=Eisen, D. P. Marshall, V. M. Billman-Jacobe, H. Coppel, R. L.A Plasmodium falciparum apical membrane antigen-1 (AMA-1) gene apparently generated by intragenic recombination [In Process Citation]Mol Biochem Parasitol  1999 100`2i 243-6lehttp://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.genetics.org/cgi/content/full/149/1/18998250683.(Escalante, A. A. Lal, A. A. Ayala, F. J.^XGenetic polymorphism and natural selection in the malaria parasite Plasmodium falciparumGenetics 1998 1491189-202it*Cruztypticulvenorynomolgi %Da"a,a'aaa)a6a7aaa&a a(a*aa'e6aansnnnn nn*nnisr'ri'ivedssigne(tecteda'rminant sifferenttifferentterential ial ial ial ial ial ial ial ial ial ial ial ial ial ial ialialhcnhcectedsrectedssn Malaria/prevention & control Malaria Vaccines Membrane Proteins/chemistry/*immunology Mice Mice, Inbred BALB C Mice, Nude Molecular Sequence Data Plasmodium chabaudi/*immunology Protozoan Proteins/chemistry/*immunology Support, Non-U.S. Gov't T-Lymphocytes/*immunology Vaccinationlogy Recombinant Proteins/genetics/immunology Saimiri Support, U.S. Gov't, Non-P.H.S. Vaccines, Synthetic/adverse effects/geneticsAm J Trop Med HygT 1994516 711-9 analysisimnestic;cientd8ee)ee6e9e:e*eee.e8e7e;eers%iiiiii+i6iii&itibodies yiesy y y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( y( yyum falciparum apical membrane antigen-1 (AMA-1)  1 Mol. Biochem. Parasitol.76 1-2333-336u,&Molecular and Biochemical Parasitology Pf Malag MalMol AMA-1^rt, U.S. Gov't, P.H.S.Mol Biochem Parasitolc 199896 1-2 27-35 yakumarVWn1111996233333676AMAAMAandantigenapicalBBiochem BiochemicalBloland conservationDE falciparu(6Phaseiloshichia ng l9lasmidsl9lasmidslasmidsodium n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n nnts, Immunologic/*administration & dosage Animal Antibodies, Protozoan/biosynthesis Antigens, Protozoan/biosynthesis/genetics/immunology Genetic Vectors/immunology/metabolism Immunization, Secondary Macaca mulatta Malaria Vaccines/*immunology Malaria, Vivax/immunology Membrane Proteins/biosynthesis/*genetics/*immunology Molecular Sequence Data Mutagenesis, Site-Directed Pichia/*genetics/immunology Plasmodium cynomolgi/immunology Plasmodium vivax/genetics/*immunology Protein Conformation Protozoan Prothttp://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.jimmunol.org/cgi-bin/Retreiver.cgi/v159n11/5535/5535-abs-frame.html 98208274>7Amante, F. 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J. van der Linde, X. Bannister, L. H. Janse, C. Waters, A. P. Thomas, A. W. Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization J Biol Chem 1998 273`2415119-24d^http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://iai.asm.org/cgi/content/full/67/1/4399081721ngKocken, C. H. Dubbeld, M. A. Van Der Wel, A. Pronk, J. T. Waters, A. P. Langermans, J. A. Thomas, A. W.SHigh-level expression of Plasmodium vivax apical membrane antigen 1 (AMA-1) in Pichia pastoris: strong immunogenicity in Macaca mulatta immunized with P. vivax AMA-1 and adjuvant SBAS2 Infect Immun 1999671 43-9http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.jimmunol.org/cgi-bin/Retreiver.cgi/v159n11/5535/5535-abs-frame.html 98208274>7Amante, F. H. Crewther, P. E. Anders, R. F. Good, M. F.sA cryptic T cell epitope on the apical membrane antigen 1 of Plasmodium chabaudi adami can prime for an anamnestic antibody response: implications for malaria vaccine designHAdoptive Transfer Amino Acid Sequence Animal Antibodies, Protozoan/*biosynthesis Drug Design *Epitopes Female Immunodominant Epitopes Lymphocyte Transformation Malaria/prevention & control Malaria Vaccines Membrane Proteins/chemistry/*immunology Mice Mice, Inbred BALB C Mice, Nude Molecular Sequence Data Plasmodium chabaudi/*immunology Protozoan Proteins/chemistry/*immunology Support, Non-U.S. Gov't T-Lymphocytes/*immunology Vaccination J Immunol 1997 159115535-44rHACrewther, P.E. Culvenor, J.G. Silva, A. Cooper, J.A. Anders, R.F. 1990nhPlasmodium falciparum: Two antigens of similar size are located in different compartments of the rhoptry Exp Parasitol@70193-206 0888 Ref1196333375@9Crewther, P. E. Matthew, M. L. Flegg, R. H. Anders, R. 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Mitchell 1988piVaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigenParasite Immunol10535-552 1205 Ref11  4 Adams, J.H. Collins, W.E. Fujioka, H. Gowda, K. Hasnain, S.E. Hoffman, S.L.Holloway, B.P. Hughes, A.L. Janse, C.J. Kappe, S.H.I. Kumar, N. Lal, A.A. Rogers, W.O. Sacci, J.B. Shi, Y.P. Thomas, A.W. Vandijk, M.R. Verra, F. Waters, A.P.Wohlhueter, R. <6Methods Methods - A Companion to Methods in Enzymology+D?Mol. Biochem. Parasitol. Molecular and Biochemical ParasitologyliProc. Nat. Acad. Sci. USA Proceedings of the National Academy of Sciences of the United States of AmericaVaccine Vaccine76)+96186517Lal, A. A. Hughes, M. A. Oliveira, D. A. Nelson, C. Bloland, P. B. Oloo, A. J. Hawley, W. E. Hightower, A. W. Nahlen, B. L. 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Parasitol.78 1-2u279-283,&Molecular and Biochemical Parasitologyhahttp://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.pnas.org/cgi/content/full/95/3/123098115903HBKappe, S. H. I. Noe, A. R. Fraser, T. S. Blair, P. L. Adams, J. 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