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Multiple sequence alignment of RAP-1 alleles in Plasmodium falciparum and homologues in other Plasmodium species 

             1                                                   50

IndiaD SLVI IFHVLFRNVA DGINVNGDNN YGKTIINNDF NFDDYNYWTP
reichinowiMSFYLGSLVI IFHVLFRNVA DGINVNGDNN YGKTIIHNDF NFDDYNYWTP
K1MSFYLGSLVI IFHVLFRNVA DGINVNGDNN YGKTIINNDF NFDDYNYWTP
HondurasI MSFYLGSLVI IFHVLFRNVA DGINVNGDNN YGKTIINNDF NFDDYNYWTP
*consensus*MSFYLGSLVI IFHVLFRNVA DGINVNGDNN YGKTIInNDF NFDDYNYWTP








             51                                                 100







IndiaD  INKKEFLNSY ENEFSSESFL ENKSSVDDGN INLTDTSTSN KSSKKGHGRS


reichinowiINKKEFLNSY EDEFSSESFL ENKSSVDDGN INLTDTSASN KSSRKGHGRS


K1INKKEFLNSY EDEFSSESFL ENKSSVDDGN INLTDTSTSN KSSKKGHGRS


HondurasI  INKKEFLNSY EDKFSSESFL ENKSSVDDGN INLTDTSTSN KSSKKGHGRS


*consensus*INKKEFLNSY EdeFSSESFL ENKSSVDDGN INLTDTStSN KSSkKGHGRS












             101                                                150







SierraLeoneASPSVVK TSTPSGTQTS GLKSSSPSST


TanzaniaASPSVVK TSTPSGTQTS GSKSSSPSST


IndiaD  RVRSASAAAI LEEDDSKDDM EFKASPSVVK TSTPSGTQTS GLKSSSPSIT


reichinowiRVRSASAAAI LEEDDSKDDI EFKASPSVVK TSTPTGTHTS GSKSSSPSST


K1RVRSASAAAI LEEDDSKDDM EFKASPSVVK TSTPSGTQTS GLKSSSPSST


HondurasI  RVRSASAAAI LEEDDSKDDM EFKASPSVVK TSTPSGTQTS GSKSSSPSST


*consensus*RVRSASAAAI LEEDDSKDDm EFKASPSVVK TSTPsGTqTS G.KSSSPSsT












             151                                                200







SierraLeoneKSSSPSNVKS ASPHGESNSS EESTTKSSKR SASXAGIVGA DEEAPPAPKN


TanzaniaKSSSPSNVKS ASPHGESNSS EESTTKSSKR SASVAGIVGA DEEAPPAPKN


IndiaD  KSSSPSNVKS ASPHGESNSS EESTTKSSKR SASVAGIVGA DEEAPPAPKN


reichinowiKSSSPSNVKT ASPHGESNSS EESTSKSSKR SASVSGIVGA DEEVPPAPKN


K1KSSSPSNVKS ASPHGESNSS EESTTKSSKR SASVAGIVGA DEEAPPAPKN


HondurasI  KSSSPSNVKS ASPHGESNSS EESTTKSSKR SASVAGIVGA DEEAPPAPKN


*consensus*KSSSPSNVKs ASPHGESNSS EESTtKSSKR SASvaGIVGA DEEaPPAPKN












             201                                                250







SierraLeoneTLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGDLVA QKEEFEYDEN


TanzaniaTLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGDLVA QKEEFEYDEN


IndiaD  TLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGDLVA QKEEFEYDEN


reichinowiTLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGQLVA QKEEFDYDEN


K1TLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGDLVA QKEEFEYDEN


HondurasI  TLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGDLVA QKEEFEYDEN


*consensus*TLTPLEELYP TNVNLFNYKY SLNNMEENIN ILKNEGdLVA QKEEFeYDEN












             251                                                300







SierraLeoneMEKAKQDKKK ALEKIGKESD EAPFMFSENK FLENQVKERN VAGS


TanzaniaMEKAKQDKKK ALEKIGKESD EEPFMFSENK FLENQVKERN VAGS


IndiaD  MEKAKQDKKK ALEKIGKQSD EEPFMFSENK FLENQVKERN VAGSFSRF


reichinowiMEKAKEEKQK ALEKIGKETD EEPFMFTDDK FLENQVKERN VAGSFSRFFS


K1MEKAKQDKKK ALEKIGKQSD EEPFMFSENK FLENQVKERN VAGSFSRFFS


HondurasI  MEKAKQDKKK ALEKIGKESD EEPFMFSENK FLENQVKERN VAGSFSRFFS


*consensus*MEKAKqdKkK ALEKIGKesD EePFMFsenK FLENQVKERN VAGSFSRFFS












             301                                                350







reichinowiKLNPFKKDEV IEKTEVSKKT YSGIGFNVND KEAKILGVGA TYQEYPETML


K1KLNPFKKDEV IEKTEVSKKT FSGIGFNLTD KEAKVLGVGA TYQEYPETML


HondurasI  KLNPFKKDEV IEKTEVSKKT FSGIGFNLTE KEAKVLGVGV TYQEYPETML


*consensus*KLNPFKKDEV IEKTEVSKKT fSGIGFNltd KEAKvLGVGa TYQEYPETML












             351                                                400







reichinowiYNCPNNSHLF DTISSLQGRL IDIKKRENMI STTFEQQKEC LKNMGVLDLE


K1YNCPNNSNLF DTIESLQGRI IDIKKRESMI STTFEQQKEC LKNMGVLDLE


HondurasI  YNCPNNSNLF DTIESLQGRI IDIKKRESMI STTFEQQKEC LKNMGVLDLE


*consensus*YNCPNNSnLF DTIeSLQGRi IDIKKREsMI STTFEQQKEC LKNMGVLDLE












             401                                                450







reichinowiLKDTECKFGT CIGSFGEHHL RLYEFENDLF KFHPNIDYLT LADGYKLQKN


K1LNDTQCKFGT CIGSFGEHHL RLYEFENDLF KFHPNIDYLT LADGYKLQKN


HondurasI  LNDTQCKFGT CIGSFGEHHL RLYEFENDLF KFHPNIDYLT LADGYKLQKN


*consensus*LnDTqCKFGT CIGSFGEHHL RLYEFENDLF KFHPNIDYLT LADGYKLQKN












             451                                                500







reichinowiHIYELSHVNF CLLNPKTLEE FLKKKEIKDL MGGDDLIKYK ENFDNFMSIS


K1HIYELSHVNF CLLNPKTLEE FLKKKEIKDL MGGDDLIKYK ENFDNFMSIS


HondurasI  HIYELSHVNF CLLNPKTLEE FLKKKEIKDL MGGDDLIKYK ENFDNFMSIS


*consensus*HIYELSHVNF CLLNPKTLEE FLKKKEIKDL MGGDDLIKYK ENFDNFMSIS












             501                                                550







reichinowiITCHIESLIY DDIEASQDVA AVLKIAKSKL HVITSGLSYK ARKLVYKIYS


K1ITCHIESLIY DDIEASQDIA AVLKIAKSKL HVITSGLSYK ARKLVYKIYS


HondurasI  ITCHIESLIY DDIEASQDIA AVLKIAKSKL HVITSGLSYK ARKLVYKIYS


consensusITCHIESLIY DDIEASQDiA AVLKIAKSKL HVITSGLSYK ARKLVYKIYS












             551                                                600







reichinowiEIQKNPDELY EKLTWIYDNI YMLKRYYTAY ALEGVCSYIE NDKTQMDTEL


K1EIQKNPDELY EKLTWIYDNI YMIKRYYTAY ALEGVCSYLE HDKSQMYTEL


HondurasI  EIQKNPDELY EKLTWIYDNI YMIKRYYTAY ALEGVCSYLE HDKSQMYTEL


*consensus*EIQKNPDELY EKLTWIYDNI YMiKRYYTAY ALEGVCSYlE hDKsQMyTEL












             601                                                650







IndiaJ2                 SCFKNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


IndiaJ1                    KNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


IndiaD               YSSCFKNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


IndiaC               YSSCFKNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


reichinowiHIYNKIVDSV RYYSSCFKNV IVYNAIMSGI HEKIKHFLKL VPRQNFLLDY


K1HIYNKIVDSV RYYSSCFKNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


HondurasI  HIYNKIVDSV RYYSSCFKNV IVYNAIISGI HEKIKHFLKL VPRHNFLLDY


*consensus*HIYNKIVDSV RYYSSCFKNV IVYNAIiSGI HEKIKHFLKL VPRhNFLLDY












             651                                                700







IndiaJ2  HFNSIFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


IndiaJ1  HFNSVFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


IndiaD  HFNSIFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


indc-cHFNSIFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


reichinowiHFNSIFEKEI KPVKKYSTSH VYYDPTVASY AYYNLDRRTM VTIINDYFEA


K1HFNSIFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


HondurasI  HFNSIFEKEI KPAKKYSTSH IYFDPTVASY AYYNLDRRTM VTIINDYFEA


consensusHFNSiFEKEI KPaKKYSTSH iYfDPTVASY AYYNLDRRTM VTIINDYFEA












             701                                                750







IndiaJ2  KKKELTVIVS RMKTDMLSIQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


IndiaJ1  KKKELTVIVS RMKTDMLSLQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


IndiaD  KKKELTVIVS RMKTDMLSLQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


IndiaC  KKKELTVIVS RMKTDMLSLQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


reichinowiKKKELTVIVS RMKTDMLSLQ NDESKIPNDK SANSKLATRL MRKFKAEIRD


K1KKKELTVIVS RMKTDMLSLQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


HondurasI  KKKELTVIVS RMKTDMLSLQ NEESKIPNDK SANSKLATRL MKKFKAEIRD


*consensus*KKKELTVIVS RMKTDMLSlQ NeESKIPNDK SANSKLATRL MkKFKAEIRD












             751                             782







IndiaJ2  FFKEMRIQYA KLINIRYRSH LKKNY


IndiaJ1  FFKEMRIQYA KLINIRYRSH


IndiaD  FFKEMRIQYA KLINIRYRSH LKKNY


IndiaC  FFKEMRIQYA KLINIRYRSH LKKNY


reichinowiFFKEMRIQYA KLINIRYKSH LKKNYFAFKR LD


K1FFKEMRIQYA KLINIRYRSH LKKNYFAFKR LD


HondurasI  FFKEMRIQYA KLINIRYRSH LKKNYFAFKR LD


*consensus*FFKEMRIQYA KLINIRYrSH LKKNYFAFKR LD





Notes:

    

  1.  Both Ala and Val were observed at X (position 184) in Sierra Leone.

References:


  2.  Ridley, R. G., Takacs, B., Lahm, H.-W., Delves, C. J., Goman, 
M., Certa, U., Matile, H., Woollett, G. R., and Scaife, J. G. (1990) 
Mol. Biochem. Parasitol. 41, 125-134


  3.  Howard, R. F. (1992) Mol. Biochem. Parasitol. 51, 327-330


  4.  Howard, R. F., Jensen, J. B., and Franklin, H. L. 
(1993) Infect. Immun. 61, 2960-2965


  5.  Howard, R. F. and Peterson, C. (1996) Mol. Biochem. Parasitol. 77, 95-98


  6.  Plasmodium reichinowii coding sequence:  accession no. U20986